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UniProtKB/Swiss-Prot entry P23223

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GP63_LEIDO
Primary accession number P23223
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 62)
Name and origin of the protein
Protein name Leishmanolysin [Precursor]
Synonyms EC 3.4.24.36
Cell surface protease
Major surface glycoprotein
Protein gp63
Promastigote surface endopeptidase
Major surface protease
Gene name
Name: gp63
From
Leishmania donovani [TaxID: 5661] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=MHOM/ET/67/HU3 / LV9;
DOI=10.1016/0166-6851(91)90113-K; PubMed=1762629 [NCBI, ExPASy, EBI, Israel, Japan]
Webb J.R., Button L.L., McMaster R.W.;
"Heterogeneity of the genes encoding the major surface glycoprotein of Leishmania donovani.";
Mol. Biochem. Parasitol. 48:173-184(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M60048; AAA29244.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A45621; A45621.
3D structure databases
HSSP P08148; 1LML. [HSSP ENTRY / PDB]
SMR P23223; 87-562.
ModBase P23223.
Protein family/group databases
MEROPS M08.001; -.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004222; Molecular function: metalloendopeptidase activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0007155; Biological process: cell adhesion (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006025; Pept_M_Zn_BS.
IPR001577; Peptidase_M8.
Graphical view of domain structure.
PANTHER PTHR10942; Peptidase_M8; 1.
Pfam PF01457; Peptidase_M8; 1.
Pfam graphical view of domain structure.
PRINTS PR00782; LSHMANOLYSIN.
PROSITE PS00142; ZINC_PROTEASE; 1.
ProtoNet P23223.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Membrane; Metal-binding; Metalloprotease; Protease; Signal; Zinc; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    39  39     Potential. 
PROPEP   40    87  48     Activation peptide. PRO_0000028661
CHAIN   88   565  478     Leishmanolysin. PRO_0000028662
PROPEP   566   590  25     Removed in mature form (By similarity). PRO_0000028663
ACT_SITE   252   252        By similarity. 
METAL   251   251        Zinc; catalytic (By similarity). 
METAL   255   255        Zinc; catalytic (By similarity). 
METAL   321   321        Zinc; catalytic (By similarity). 
LIPID   565   565        GPI-anchor amidated asparagine (By similarity). 
CARBOHYD   287   287        N-linked (GlcNAc...) (Potential). 
DISULFID   112   129        By similarity. 
DISULFID   178   217        By similarity. 
DISULFID   301   373        By similarity. 
DISULFID   380   443        By similarity. 
DISULFID   393   412        By similarity. 
DISULFID   402   477        By similarity. 
DISULFID   454   498        By similarity. 
DISULFID   503   553        By similarity. 
DISULFID   523   546        By similarity. 
Sequence information
Length: 590 AA [This is the length of the unprocessed precursor] Molecular weight: 62950 Da [This is the MW of the unprocessed precursor] CRC64: 0FB315D299659F58 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVDSSSTHR HRSVAARLVR LAAAGAAVIA AVGTAAAWAH AGAVQHRCIH DAMQARVRQS 

        70         80         90        100        110        120 
VARHHTAPGA VSAVGLSYVT LGAAPTVVRA ANWGALRIAV STEDLTDSAY HCARVGQRIS 

       130        140        150        160        170        180 
TRDGRFAICT AEDILTDEKR DILVKYLIPQ ALQLHTERLK VRQVQDKWKV TGMGNEICGH 

       190        200        210        220        230        240 
FKVPPAHITD GLSNTDFVMY VASVPSEGDV LAWATTCQVF SDGHPAVGVI NIPAANIASR 

       250        260        270        280        290        300 
YDQLVTRVVT HEMAHALGFS VVFFRDARIL ESISNVRHKD FDVPVINSST AVAKAREQYG 

       310        320        330        340        350        360 
CGTLEYLEME DQGGAGSAGS HIKMRNAQDE LMAPASDAGY YSALTMAIFQ DLGFYQADFS 

       370        380        390        400        410        420 
KAEEMPWGRN AGCAFLSEKC MEDGITKWPA MFCNENEVTM RCHTGRLSLG VCGLSSSDIP 

       430        440        450        460        470        480 
LPPYWQYFTD PLLAGISAFM DYCPVVVPFG DGSCAQRASE AGAPFKGFNV FSDAARCIDG 

       490        500        510        520        530        540 
AFRPKTTETV TNSYAGLCAN VRCDTATRTY SVQVHGGSGY ANCTPGLRVE LSTVSSAFEE 

       550        560        570        580        590 
GGYITCPPYV EVCQGNVQAA KDGGNAAAGR RGPRAAATAL LVAALLAVAL
P23223 in FASTA format

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