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UniProtKB/Swiss-Prot entry P23220

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT2B1_PIG
Primary accession number P23220
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 76)
Name and origin of the protein
Protein name Plasma membrane calcium-transporting ATPase 1
Synonyms PMCA1
EC 3.6.3.8
Plasma membrane calcium pump isoform 1
Gene name
Name: ATP2B1
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Stomach smooth muscle;
PubMed=2147100 [NCBI, ExPASy, EBI, Israel, Japan]
de Jaegere S., Wuytack F., Eggermont J.A., Verboomen H., Casteels R.;
"Molecular cloning and sequencing of the plasma-membrane Ca2+ pump of pig smooth muscle.";
Biochem. J. 271:655-660(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53456; CAA37536.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13057; S13057.
RefSeq NP_999517.1; -.
UniGene Ssc.55555
3D structure databases
HSSP P04191; 1EUL. [HSSP ENTRY / PDB]
ModBase P23220.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0005388; Molecular function: calcium-transporting ATPase activity (inferred from electronic annotation from InterPro).
GO:0005516; Molecular function: calmodulin binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from InterPro).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006408; ATPase-IIB_Ca.
IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01517; ATPase-IIB_Ca; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet P23220.
Genome annotation databases
GeneID 397636; -.
KEGG ssc:397636; -.
Phylogenomic databases
HOVERGEN P23220; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Calcium; Calcium transport; Calmodulin-binding; Cell membrane; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1220  1220     Plasma membrane calcium-transporting ATPase 1. PRO_0000046210
TOPO_DOM   1     97  97     Cytoplasmic (Potential). 
TRANSMEM   98    118  21     Potential. 
TOPO_DOM   119    154  36     Extracellular (Potential). 
TRANSMEM   155    175  21     Potential. 
TOPO_DOM   176    366  191     Cytoplasmic (Potential). 
TRANSMEM   367    386  20     Potential. 
TOPO_DOM   387    419  33     Extracellular (Potential). 
TRANSMEM   420    437  18     Potential. 
TOPO_DOM   438    852  415     Cytoplasmic (Potential). 
TRANSMEM   853    872  20     Potential. 
TOPO_DOM   873    882  10     Extracellular (Potential). 
TRANSMEM   883    903  21     Potential. 
TOPO_DOM   904    923  20     Cytoplasmic (Potential). 
TRANSMEM   924    946  23     Potential. 
TOPO_DOM   947    964  18     Extracellular (Potential). 
TRANSMEM   965    986  22     Potential. 
TOPO_DOM   987   1005  19     Cytoplasmic (Potential). 
TRANSMEM   1006   1027  22     Potential. 
TOPO_DOM   1028   1037  10     Extracellular (Potential). 
TRANSMEM   1038   1059  22     Potential. 
TOPO_DOM   1060   1220  161     Cytoplasmic (Potential). 
REGION   1100   1117  18     Calmodulin-binding subdomain A (By similarity). 
REGION   1118   1127  10     Calmodulin-binding subdomain B (By similarity). 
COMPBIAS   296    299  4     Poly-Glu. 
ACT_SITE   475    475        4-aspartylphosphate intermediate (By similarity). 
METAL   797    797        Magnesium (By similarity). 
METAL   801    801        Magnesium (By similarity). 
MOD_RES   1116   1116        Phosphothreonine; by PKC (By similarity). 
MOD_RES   1155   1155        Phosphoserine (By similarity). 
MOD_RES   1182   1182        Phosphoserine (By similarity). 
Sequence information
Length: 1220 AA [This is the length of the unprocessed precursor] Molecular weight: 134710 Da [This is the MW of the unprocessed precursor] CRC64: 3372FAF67F82401A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGDMANNSVA YGGVKNSLKE ANHDGDFGIT LADVRALMEL RSTDALRKIQ ESYGDVYGIC 

        70         80         90        100        110        120 
TRLKTSPVEG LSGNPADIER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 

       130        140        150        160        170        180 
SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 

       190        200        210        220        230        240 
FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 

       250        260        270        280        290        300 
SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGI NSQTGIIFTL LGAGGEEEEK 

       310        320        330        340        350        360 
KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 

       370        380        390        400        410        420 
VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 

       430        440        450        460        470        480 
IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 

       490        500        510        520        530        540 
TMNRMTVVQA YINEKHYKKI PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 

       550        560        570        580        590        600 
VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 

       610        620        630        640        650        660 
KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 

       670        680        690        700        710        720 
EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 

       730        740        750        760        770        780 
KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 

       790        800        810        820        830        840 
IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 

       850        860        870        880        890        900 
AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 

       910        920        930        940        950        960 
ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 

       970        980        990       1000       1010       1020 
NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 

      1030       1040       1050       1060       1070       1080 
IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 

      1090       1100       1110       1120       1130       1140 
IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS 

      1150       1160       1170       1180       1190       1200 
IHNFMTHPEF RIEDSEPHIP LIDDTDAEDD APTKRNCSPP PSPNKNNNAV DSGIYLTIEM 

      1210       1220 
NKSATSSSPG SPLHSLETSL
P23220 in FASTA format

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