[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=1918003 [NCBI, ExPASy, EBI, Israel, Japan]
Munger J.S.,
Shi G.P.,
Mark E.A.,
Chin D.T.,
Gerard C.,
Chapman H.A.;
"A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases.";
J. Biol. Chem. 266:18832-18838(1991).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Liver;
DOI=10.1021/bi00094a018; PubMed=8218228 [NCBI, ExPASy, EBI, Israel, Japan]
Kroetz D.L.,
McBride O.W.,
Gonzalez F.J.;
"Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.";
Biochemistry 32:11606-11617(1993).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Peripheral blood, and Placenta;
DOI=10.1006/geno.1993.1285; PubMed=8406473 [NCBI, ExPASy, EBI, Israel, Japan]
Shibata F.,
Takagi Y.,
Kitajima M.,
Kuroda T.,
Omura T.;
"Molecular cloning and characterization of a human carboxylesterase gene.";
Genomics 17:76-82(1993).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Liver;
PubMed=8049197 [NCBI, ExPASy, EBI, Israel, Japan]
Becker A.,
Bottcher A.,
Lackner K.J.,
Fehringer P.,
Notka F.,
Aslanidis C.,
Schmitz G.;
"Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase.";
Arterioscler. Thromb. 14:1346-1355(1994).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH BETA-GLUCURONIDASE.
TISSUE=Liver;
DOI=10.1006/abbi.1999.1449; PubMed=10562416 [NCBI, ExPASy, EBI, Israel, Japan]
Islam M.R.,
Waheed A.,
Shah G.N.,
Tomatsu S.,
Sly W.S.;
"Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C-terminus of beta-glucuronidase is involved in their interaction.";
Arch. Biochem. Biophys. 372:53-61(1999).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Macrophage;
PubMed=11015575 [NCBI, ExPASy, EBI, Israel, Japan]
Ghosh S.;
"Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA.";
Physiol. Genomics 2:1-8(2000).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PROTEIN SEQUENCE OF 19-28.
TISSUE=Liver;
DOI=10.1006/prep.2001.1553; PubMed=11812220 [NCBI, ExPASy, EBI, Israel, Japan]
Alam M.,
Ho S.,
Vance D.E.,
Lehner R.;
"Heterologous expression, purification, and characterization of human triacylglycerol hydrolase.";
Protein Expr. Purif. 24:33-42(2002).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
TISSUE=Liver;
Hosokawa M.,
Yaginuma Y.,
Watanabe N.,
Yamamoto N.,
Tsukada E.,
Ohhata Y.,
Satoh T.,
Chiba K.;
"Inverted duplication of human carboxylesterase 1(CES1) genes, which are difference in regulation at the transcriptional level.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT GLN-362 DEL.
TISSUE=Heart, and Oesophagus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-362 DEL.
TISSUE=Blood, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-429 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1016/S0014-5793(99)01111-4; PubMed=10518925 [NCBI, ExPASy, EBI, Israel, Japan]
Mori M.,
Hosokawa M.,
Ogasawara Y.,
Tsukada E.,
Chiba K.;
"cDNA cloning, characterization and stable expression of novel human brain carboxylesterase.";
FEBS Lett. 458:17-22(1999).
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[12]
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PROTEIN SEQUENCE OF 18-28; 65-78; 93-107; 243-255; 258-266; 297-313 AND 341-346, CATALYTIC ACTIVITY, ENZYME REGULATION, AND BIOPHYSICOCHEMICAL PROPERTIES.
TISSUE=Liver;
DOI=10.1046/j.1432-1327.1998.2510863.x; PubMed=9490062 [NCBI, ExPASy, EBI, Israel, Japan]
Schindler R.,
Mentlein R.,
Feldheim W.;
"Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family.";
Eur. J. Biochem. 251:863-873(1998).
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[13]
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PROTEIN SEQUENCE OF 19-34, NUCLEOTIDE SEQUENCE [MRNA] OF 113-121; 138-149; 216-224; 351-357 AND 466-471, AND SUBUNIT.
TISSUE=Liver;
DOI=10.1016/0378-4274(95)03493-5; PubMed=8597091 [NCBI, ExPASy, EBI, Israel, Japan]
Satoh T.,
Hosokawa M.;
"Molecular aspects of carboxylesterase isoforms in comparison with other esterases.";
Toxicol. Lett. 82:439-445(1995).
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[14]
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PROTEIN SEQUENCE OF 19-28, ACTIVE SITES, GLYCOSYLATION AT ASN-79, AND MUTAGENESIS OF ASN-79; SER-221; GLU-354; HIS-468 AND 564-HIS--LEU-567.
DOI=10.1021/bi0255625; PubMed=12022871 [NCBI, ExPASy, EBI, Israel, Japan]
Alam M.,
Vance D.E.,
Lehner R.;
"Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site.";
Biochemistry 41:6679-6687(2002).
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[15]
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NUCLEOTIDE SEQUENCE [MRNA] OF 61-567.
TISSUE=Liver;
DOI=10.1016/0024-3205(91)90515-D; PubMed=1997784 [NCBI, ExPASy, EBI, Israel, Japan]
Long R.M.,
Calabrese M.R.,
Martin B.M.,
Pohl L.R.;
"Cloning and sequencing of a human liver carboxylesterase isoenzyme.";
Life Sci. 48:PL43-PL49(1991).
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[16]
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NUCLEOTIDE SEQUENCE [MRNA] OF 64-567, AND PARTIAL PROTEIN SEQUENCE.
PubMed=2070086 [NCBI, ExPASy, EBI, Israel, Japan]
Zschunke F.,
Salmassi A.,
Kreipe H.,
Buck F.,
Parwaresch M.R.,
Radzun H.J.;
"cDNA cloning and characterization of human monocyte/macrophage serine esterase-1.";
Blood 78:506-512(1991).
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[17]
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NUCLEOTIDE SEQUENCE [MRNA] OF 114-567.
TISSUE=Liver;
DOI=10.1016/0378-1119(91)90448-K; PubMed=1748313 [NCBI, ExPASy, EBI, Israel, Japan]
Riddles P.W.,
Richards L.J.,
Bowles M.R.,
Pond S.M.;
"Cloning and analysis of a cDNA encoding a human liver carboxylesterase.";
Gene 108:289-292(1991).
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[18]
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BIOPHYSICOCHEMICAL PROPERTIES, VARIANT GLU-143, AND CHARACTERIZATION OF VARIANT GLU-143.
DOI=10.1016/j.ajhg.2008.04.015; PubMed=18485328 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu H.-J.,
Patrick K.S.,
Yuan H.-J.,
Wang J.-S.,
Donovan J.L.,
DeVane C.L.,
Malcolm R.,
Johnson J.A.,
Youngblood G.L.,
Sweet D.H.,
Langaee T.Y.,
Markowitz J.S.;
"Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.";
Am. J. Hum. Genet. 82:1241-1248(2008).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH SUBSTRATE.
DOI=10.1016/S1074-5521(03)00071-1; PubMed=12725862 [NCBI, ExPASy, EBI, Israel, Japan]
Bencharit S.,
Morton C.L.,
Hyatt J.L.,
Kuhn P.,
Danks M.K.,
Potter P.M.,
Redinbo M.R.;
"Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition.";
Chem. Biol. 10:341-349(2003).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH SUBSTRATES.
DOI=10.1038/nsb919; PubMed=12679808 [NCBI, ExPASy, EBI, Israel, Japan]
Bencharit S.,
Morton C.L.,
Xue Y.,
Potter P.M.,
Redinbo M.R.;
"Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.";
Nat. Struct. Biol. 10:349-356(2003).
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