ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P22988

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LDHA_HORVU
Primary accession number P22988
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on August 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 62)
Name and origin of the protein
Protein name L-lactate dehydrogenase A
Synonyms LDH-A
EC 1.1.1.27
Gene name None
From
Hordeum vulgare (Barley) [TaxID: 4513] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Pooideae; Triticeae; Hordeum.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=cv. Himalaya;
TISSUE=Root;
PubMed=1698294 [NCBI, ExPASy, EBI, Israel, Japan]
Hondred D., Hanson A.D.;
"Hypoxically inducible barley lactate dehydrogenase: cDNA cloning and molecular analysis.";
Proc. Natl. Acad. Sci. U.S.A. 87:7300-7304(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M55685; AAA62696.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A36070; A36070.
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
ModBase P22988.
Organism-specific databases
Gramene P22988; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006950; Biological process: response to stress (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet P22988.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycolysis; NAD; Oxidoreductase; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   356  356     L-lactate dehydrogenase A. PRO_0000168489
NP_BIND   75    80  6     NAD (By similarity). 
ACT_SITE   215   215        Proton acceptor (By similarity). 
BINDING   121   121        NAD (By similarity). 
BINDING   128   128        Substrate (By similarity). 
BINDING   160   160        NAD or substrate (By similarity). 
BINDING   191   191        Substrate (By similarity). 
BINDING   270   270        Substrate (By similarity). 
Sequence information
Length: 356 AA [This is the length of the unprocessed precursor] Molecular weight: 37749 Da [This is the MW of the unprocessed precursor] CRC64: 7B82D6F1D0BF5AD8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MHKASSLSEL GFDAGGASSG FFRPVADGCP ATPTSSAVPH RRLTKISVIG AGNVGMAIAQ 

        70         80         90        100        110        120 
TILTQNLADE IALVDALPDK LRGEALDLQH AAAFLPRVRI SGTDAAVTKN SDLVIVTAGA 

       130        140        150        160        170        180 
RQIPGETRLN LLQRNVALYR KIVPPVAEHS PDALLLVVSN PVDVLTYVAW KLSGFPASRV 

       190        200        210        220        230        240 
IGSGTNLDSS RFRFLIAEHL DVNAQDVQAY MVGEHGDSSV AIWSSISVGG MPAFKSLRDS 

       250        260        270        280        290        300 
HRSFDEAALE GIRRAVVGGA YEVIGLKGYT SWAIGYSVAS LAASLLRDQR RVHPVSVLAS 

       310        320        330        340        350 
GFHGISDGHE VFLSLPARLG RGGILGVAEM DLTEAEAAQL RRSAKTLWEN CQLLDL
P22988 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!