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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0042-6822(90)90356-V; PubMed=2219708 [NCBI, ExPASy, EBI, Israel, Japan]
Thornbury D.W.,
Patterson C.A.,
Dessens J.T.,
Pirone T.P.;
"Comparative sequence of the helper component (HC) region of potato virus Y and a HC-defective strain, potato virus C.";
Virology 178:573-578(1990).
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[2]
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REVIEW.
DOI=10.1016/S0168-1702(01)00220-9; PubMed=11226583 [NCBI, ExPASy, EBI, Israel, Japan]
Urcuqui-Inchima S.,
Haenni A.L.,
Bernardi F.;
"Potyvirus proteins: a wealth of functions.";
Virus Res. 74:157-175(2001).
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- FUNCTION: Helper component proteinase is required for aphid transmission and also has proteolytic activity. Interacts with virions and aphid stylets. Seems to act as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.
- CATALYTIC ACTIVITY: Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
- DOMAIN: The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.
- PTM: The viral RNA of potyviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically (By similarity).
- SIMILARITY: Belongs to the potyviruses polyprotein family.
- SIMILARITY: Contains 1 peptidase C6 domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 856 AA [This is the length of the partial sequence of the unprocessed precursor] |
Molecular weight: 96813 Da [This is the MW of the partial sequence of the unprocessed precursor] |
CRC64: 4645EB6D5FD0A0A2 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MATYMSTICF GSFECKLPYS PASCGHIVKE REVPASVDPF ADLETQLSAR LRKQEYATVR
70 80 90 100 110 120
VLKNGTFTYR YKTDAQIMRI QKKLERKDRE EYHFQMAAPS IVSKITIAGG DPPSKSEPQA
130 140 150 160 170 180
PRGIIHTTPK VRKVKTRPII KLTEGQMNHL IKQVKQIMSE KRGSVHLISK KTTHVQYKEI
190 200 210 220 230 240
LGATRAAVRT AHMMGLRRRV DFRCDTWTVG LLQRLARTDK WSNQVRTIHV RRGDSGVILN
250 260 270 280 290 300
TKSLKGHFGR SSGDLFIVRG SHEGKLYDAR SRVTQSVLNS MIQFSNADNF WKGLDGNWAR
310 320 330 340 350 360
MRYPSDHTCV AGLPVADCGR VAALTRHSIL PCYKITCPTC AQQYASLPVS DLFKLLHKHA
370 380 390 400 410 420
RDGLNRLGAD KDRFIHVNKF LMALEHLTEP VDLNLELFNE IFKSIGEKQQ APFKNLNVLN
430 440 450 460 470 480
NFFLKGKENT AHEWQVAQLS LLELARFQKN RTDNIKKGDI SFFRNKLSAR ANWNLYLSCD
490 500 510 520 530 540
NQLDKNANFL WGQREYHAKR FFSNFFDEID PAKGYSAYEI RKHPNGTRKL SIGNLVVPLD
550 560 570 580 590 600
LAEFRQKMKG DYRKQPGVSR KCTSSKDGNY VYPCCCTTLD DGSAIESTFY PPTKKHLVIG
610 620 630 640 650 660
NSGDQKFVDL PKGDSEMLYI AKQGYCYINV FLAMLINISE EDAKDFTKKV RDMCVPKLGT
670 680 690 700 710 720
WPTMMDLATT CAQMRIFYPD VHDAELPRIL VDHDTQTCHV VDSFGSQTTG YHILKASSVS
730 740 750 760 770 780
QLILFANDEL ESDIKHYRVG GVPNACPELG STISPFREGG VIMSESAALK LLLKGIFRPR
790 800 810 820 830 840
VMRQLLLDEP YLLILSILSP GILMAMYNNG IFELAVRLWI NEKQSIAMIA SLLSALALRV
850
SAAETLVAQR IIIDAA
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P22602 in FASTA format |
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