[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2162841 [NCBI, ExPASy, EBI, Israel, Japan] Hamilton S.E., Hurley J.B.; "A phosphodiesterase inhibitor specific to a subset of bovine retinal cones."; J. Biol. Chem. 265:11259-11264(1990).

Comments

FUNCTION: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
CATALYTIC ACTIVITY: Guanosine 3',5'-cyclic phosphate + H₂O = guanosine 5'-phosphate.
SUBUNIT: Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
DOMAIN: The C-terminal region is important in conferring inhibition.
SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J05578; AAA30689.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_776847.1; -.

UniGene

Bt.445

3D structure databases

ModBase

P22571.

Ontologies

GO:0004114;	Molecular function: 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred from electronic annotation from InterPro).
GO:0030553;	Molecular function: cGMP binding (inferred from electronic annotation from InterPro).
GO:0050896;	Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007601;	Biological process: visual perception (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006952; PDE6_gamma.
Graphical view of domain structure.

PANTHER

PTHR12122; PDE6_gamma; 1.

Pfam

PF04868; PDE6_gamma; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000969; 35-cGMP_Pdiase_g; 1.

ProtoNet

P22571.

Genome annotation databases

Ensembl

ENSBTAG00000013635; Bos taurus. [Contig view]

GeneID

281978; -.

KEGG

bta:281978; -.

Phylogenomic databases

HOVERGEN

P22571; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

cGMP; Hydrolase; Sensory transduction; Vision.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 83`	`83`	`Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma.`	`PRO_0000166119`
`COMPBIAS`	`20 41`	`22`	`Arg/Lys-rich (basic).`

Sequence information

Length: 83 AA [This is the length of the unprocessed precursor]

Molecular weight: 9102 Da [This is the MW of the unprocessed precursor]

CRC64: 755D0639015327DA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 

        70         80 
TVICPWEAFS HLELHELAQF GII

P22571 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools