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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=1701177 [NCBI, ExPASy, EBI, Israel, Japan]
Sato R.,
Komine Y.,
Imanaka T.,
Takano T.;
"Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis. Isolation and characterization of a cDNA clone for the antigen.";
J. Biol. Chem. 265:21232-21236(1990).
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[2]
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PROTEIN SEQUENCE OF 20-44, AND GLYCOSYLATION.
DOI=10.1016/0167-4838(92)90417-C; PubMed=1372829 [NCBI, ExPASy, EBI, Israel, Japan]
Nakashima N.,
Miyazaki K.,
Ishikawa M.,
Yatohgo T.,
Ogawa H.,
Uchibori H.,
Matsumoto I.,
Seno N.,
Hayashi M.;
"Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide.";
Biochim. Biophys. Acta 1120:1-10(1992).
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- FUNCTION: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
- SUBUNIT: Interacts with SERPINE1/PAI1 (By similarity). Monomer.
- SUBCELLULAR LOCATION: Secreted, extracellular space.
- TISSUE SPECIFICITY: Plasma.
- DOMAIN: The SMB domain mediates interaction with SERPINE1/PAI1 (By similarity).
- PTM: Sulfated on 2 tyrosine residues (By similarity).
- PTM: N- and O-glycosylated.
- PTM: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
- SIMILARITY: Contains 4 hemopexin-like domains.
- SIMILARITY: Contains 1 SMB (somatomedin-B) domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 475 AA [This is the length of the unprocessed precursor] |
Molecular weight: 53943 Da [This is the MW of the unprocessed precursor] |
CRC64: D5D1F31B8C2FA12D [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAPLRPIFTL ALLLWVVLAD QESCKDRCTE GFNANRKCQC DELCSYYQSC CADYAAECKP
70 80 90 100 110 120
QVTRGDVFTM PEDEYGPYDY IEQTKDNASV HAQPESPTVG QEPTLSPDLQ TEGGAEPTHE
130 140 150 160 170 180
VPLEPEMETL RPEGEDLQAG TTELGTSASP AEEELCSGKP FDAFTDLKNG SLFAFRGQYC
190 200 210 220 230 240
YELDETAVRP GYPKLIQDVW GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGILDPDYP
250 260 270 280 290 300
RNISEGFSGI PDNVDAAFAL PAHSYSGRER VYFFKGDKYW EYQFQQQPSQ EECEGSSLSA
310 320 330 340 350 360
VFEHFAMLHR DSWEDIFKLL FWGRPSGGAR QPQFISRDWH GVPGKVDAAM AGRIYISGLT
370 380 390 400 410 420
PSPSAKKQKS RRRSRKRYRS RYGRGRSQNS RRLSRSISRL WFSSEEVSLG PYNYEDYETS
430 440 450 460 470
WLKPATSEPI QSVYFFSGDK YYRVNLRTQR VDTVNPPYPR SIAQYWLGCP APGGQ
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P22458 in FASTA format |
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ExPASy Home page
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