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UniProtKB/Swiss-Prot entry P22434


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDE1_YEAST
Primary accession number P22434
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on October 1, 1996 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name 3',5'-cyclic-nucleotide phosphodiesterase 1
Synonyms PDEase 1
EC 3.1.4.17
Low-affinity cAMP phosphodiesterase
3':5'-CNP
Gene name
Name: PDE1
OrderedLocusNames: YGL248W
ORFNames: NRB369
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2824992 [NCBI, ExPASy, EBI, Israel, Japan]
Nikawa J., Sass P., Wigler M.;
"Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.";
Mol. Cell. Biol. 7:3629-3636(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
DOI=10.1002/(SICI)1097-0061(199612)12:15<1555::AID-YEA43>3.3.CO;2-H; PubMed=8972578 [NCBI, ExPASy, EBI, Israel, Japan]
Coissac E., Maillier E., Robineau S., Netter P.;
"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae.";
Yeast 12:1555-1562(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9169869 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[4]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-311; SER-313 AND SER-314, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M700468-MCP200; PubMed=18407956 [NCBI, ExPASy, EBI, Israel, Japan]
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M17781; AAA34896.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X94357; CAA64139.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z72770; CAA96968.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S61613; ESBYPC.
RefSeq NP_011266.1; -.
3D structure databases
ModBase P22434.
Organism-specific databases
CYGD YGL248w; -.
SGD S000003217; PDE1.
Yeast-GFP YGL248W.
Gene expression databases
GermOnline YGL248W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity (inferred from electronic annotation from InterPro).
GO:0006198; Biological process: cAMP catabolic process (inferred from electronic annotation from InterPro).
GO:0019933; Biological process: cAMP-mediated signaling (inferred from mutant phenotype from SGD).
QuickGo view.
Family and domain databases
InterPro IPR000396; Pdiesterase2.
Graphical view of domain structure.
Pfam PF02112; PDEase_II; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000962; Cyc_nuc_PDEase; 1.
PRINTS PR00388; PDIESTERASE2.
ProDom PD010003; Pdiesterase2_lac; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00607; PDEASE_II; 1.
ProtoNet P22434.
Genome annotation databases
Ensembl YGL248W; Saccharomyces cerevisiae. [Contig view]
GeneID 852644; -.
GenomeReviews Y13135_GR; YGL248W.
KEGG sce:YGL248W; -.
NMPDR fig|4932.3.peg.2369; -.
Phylogenomic databases
HOGENOM P22434; -.
Other
LinkHub P22434; -.
NextBio 971903; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP; Complete proteome; Hydrolase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   369  369     3',5'-cyclic-nucleotide phosphodiesterase 1. PRO_0000206791
MOD_RES   311   311        Phosphotyrosine. 
MOD_RES   313   313        Phosphoserine. 
MOD_RES   314   314        Phosphoserine. 
CONFLICT   94    94        L -> F (in Ref. 1; AAA34896). 
Sequence information
Length: 369 AA [This is the length of the unprocessed precursor] Molecular weight: 42016 Da [This is the MW of the unprocessed precursor] CRC64: 47B752477E99BA88 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVVFEITILG ANGGPTEYGT QCFILKPART EDPELIAVDG GAGMYQLREM LVQGRNENEG 

        70         80         90        100        110        120 
DDELVPSFYE HDREPIEFFI DSKLNIQKGL SKSLLQSLKR QGEHFESANT MKKTYEVFQG 

       130        140        150        160        170        180 
ITDYYITHPH LDHISGLVVN SPSIYEQENS KKKTIWGLPH TIDVLQKHVF NDLIWPDLTA 

       190        200        210        220        230        240 
ERSRKLKLKC LNPKEVQKCT IFPWDVIPFK VHHGIGVKTG APVYSTFYIF RDRKSKDCII 

       250        260        270        280        290        300 
VCGDVEQDRR ESEESLLEEF WSYVAENIPL VHLKGILVEC SCPLSSKPEQ LYGHLSPIYL 

       310        320        330        340        350        360 
INELSNLNTL YNSSKGLSGL NVIVTHVKST PAKRDPRLTI LEELRFLAEE RNLGDLRISI 


ALEGHTLFL 

P22434 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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