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UniProtKB/Swiss-Prot entry P22415


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name USF1_HUMAN
Primary accession number P22415
Secondary accession number Q5SY46
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on August 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name Upstream stimulatory factor 1
Synonym Major late transcription factor 1
Gene name
Name: USF1
Synonyms: USF
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-25.
PubMed=2249772 [NCBI, ExPASy, EBI, Israel, Japan]
Gregor P.D., Sawadogo M., Roeder R.G.;
"The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.";
Genes Dev. 4:1730-1740(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Fukamizu A.;
"Human USF1 genomic sequence.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs program for genomic applications;
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH VARICELLA-ZOSTER VIRUS IE62 PROTEIN.
DOI=10.1099/vir.0.19335-0; PubMed=14573800 [NCBI, ExPASy, EBI, Israel, Japan]
Rahaus M., Desloges N., Yang M., Ruyechan W.T., Wolff M.H.;
"Transcription factor USF, expressed during the entire phase of Varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication.";
J. Gen. Virol. 84:2957-2967(2003).
[7]
X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 197-260.
PubMed=8306960 [NCBI, ExPASy, EBI, Israel, Japan]
Ferre-D'Amare A.R., Pognonec P., Roeder R.G., Burley S.K.;
"Structure and function of the b/HLH/Z domain of USF.";
EMBO J. 13:180-189(1994).
[8]
INVOLVEMENT IN HYPLIP1.
DOI=10.1038/ng1320; PubMed=14991056 [NCBI, ExPASy, EBI, Israel, Japan]
Pajukanta P., Lilja H.E., Sinsheimer J.S., Cantor R.M., Lusis A.J., Gentile M., Duan X.J., Soro-Paavonen A., Naukkarinen J., Saarela J., Laakso M., Ehnholm C., Taskinen M.-R., Peltonen L.;
"Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).";
Nat. Genet. 36:371-376(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X55666; CAA39201.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB017568; BAA76541.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY593992; AAS89301.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591806; CAI15372.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035505; AAH35505.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13525; S13525.
RefSeq NP_009053.1; -.
UniGene Hs.414880
3D structure databases
PDB
1AN4; X-ray; 2.90 A; A/B=197-260.[ExPASy / RCSB / EBI]
PDBsum 1AN4; -.
ModBase P22415.
Protein-protein interaction databases
DIP DIP:654N; -.
IntAct P22415; -.
PTM databases
PhosphoSite P22415; -.
Organism-specific databases
H-InvDB HIX0001226; -.
HGNC HGNC:12593; USF1.
GenAtlas USF1.
HPA CAB001480; -.
MIM 144250; phenotype. [NCBI / EBI]
191523; gene. [NCBI / EBI]
602491; phenotype. [NCBI / EBI]
PharmGKB PA37223; -.
GeneCards P22415.
Gene expression databases
ArrayExpress P22415; -.
CleanEx HS_USF1; -.
GermOnline ENSG00000158773; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0043425; Molecular function: bHLH transcription factor binding (inferred from physical interaction from UniProtKB).
GO:0046982; Molecular function: protein heterodimerization activity (inferred from physical interaction from UniProtKB).
GO:0042803; Molecular function: protein homodimerization activity (inferred from physical interaction from UniProtKB).
GO:0003705; Molecular function: RNA polymerase II transcription factor activity, enhancer binding (inferred from direct assay from UniProtKB).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from direct assay from UniProtKB).
GO:0042593; Biological process: glucose homeostasis (traceable author statement from UniProtKB).
GO:0019086; Biological process: late viral mRNA transcription (inferred from direct assay from UniProtKB).
GO:0055088; Biological process: lipid homeostasis (inferred from sequence or structural similarity from UniProtKB).
GO:0051918; Biological process: negative regulation of fibrinolysis (inferred by curator from UniProtKB).
GO:0010552; Biological process: positive regulation of specific transcription from RNA polymerase II promoter (inferred from mutant phenotype from UniProtKB).
GO:0000432; Biological process: positive regulation of transcription from RNA polymerase II promoter by glucose (inferred from mutant phenotype from UniProtKB).
GO:0001666; Biological process: response to hypoxia (inferred from mutant phenotype from UniProtKB).
GO:0009411; Biological process: response to UV (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001092; HLH_basic.
IPR011598; HLH_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:4.10.280.10; HLH_DNA_bd; 1.
Pfam PF00010; HLH; 1.
Pfam graphical view of domain structure.
SMART SM00353; HLH; 1.
SMART graphical view of domain structure.
PROSITE PS50888; HLH; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P22415.
Genome annotation databases
Ensembl ENSG00000158773; Homo sapiens. [Contig view]
GeneID 7391; -.
KEGG hsa:7391; -.
Phylogenomic databases
HOGENOM P22415; -.
HOVERGEN P22415; -.
Other
LinkHub P22415; -.
NextBio 28938; -.
SOURCE USF1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Direct protein sequencing; DNA-binding; Nucleus; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   310  310     Upstream stimulatory factor 1. PRO_0000127496
DOMAIN   213   255  43     Helix-loop-helix motif. 
DOMAIN   271   292  22     Leucine-zipper (Potential). 
DNA_BIND   200   212  13     Basic motif. 
HELIX   205   225  21      
STRAND   233   236  4      
TURN   240   247  8      
HELIX   248   255  8      
TURN   256   258  3      
Sequence information
Length: 310 AA [This is the length of the unprocessed precursor] Molecular weight: 33538 Da [This is the MW of the unprocessed precursor] CRC64: BFDA91519B4B80AE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM 

        70         80         90        100        110        120 
YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGT AAETHYTYFP 

       130        140        150        160        170        180 
STAVGDGAGG TTSGSTAAVV TTQGSEALLG QATPPGTGQF FVMMSPQEVL QGGSQRSIAP 

       190        200        210        220        230        240 
RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK 

       250        260        270        280        290        300 
GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 

       310 
LEVVIKNDSN 

P22415 in FASTA format

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