[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1007/BF00383311; PubMed=2993814 [NCBI, ExPASy, EBI, Israel, Japan] Hamilton P.T., Reeve J.N.; "Structure of genes and an insertion element in the methane producing archaebacterium Methanobrevibacter smithii."; Mol. Gen. Genet. 200:47-59(1985).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X02587; CAA26425.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S28654; S28654.

3D structure databases

ModBase

P22350.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004735;	Molecular function: pyrroline-5-carboxylate reductase activity (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

PS00521; P5CR; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 251`	`251`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187313`

Sequence information

Length: 251 AA [This is the length of the unprocessed precursor]

Molecular weight: 27859 Da [This is the MW of the unprocessed precursor]

CRC64: E8B1361C9AF80C65 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNLGIIGYGN IGELLSQNII SHDFCNLNKL YIANRTLSKI NHLKDIDPRI SITDDNIEVA 

        70         80         90        100        110        120 
KTCEKIIISV KTPDLAIVLD PLKPHITKNQ QIIHTCAGTD LEFKDCGLSC VIPTISSTYD 

       130        140        150        160        170        180 
EDNPKKGVSI IMHDENVSGE NREFVEKLFS KFSQIKVVDS PMDLEIATIA ASCMPAFIAL 

       190        200        210        220        230        240 
GVDLFAGELE EKCNLSKEET FKILAETLNS TAYILKEDIY SPDELINKVA TKNGITQKGL 

       250 
DVLDKRPARY L

P22350 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools