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UniProtKB/Swiss-Prot entry P22281

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDHX_YEAST
Primary accession number P22281
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on August 1, 1991 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 64)
Name and origin of the protein
Protein name Aldehyde dehydrogenase 1, mitochondrial [Precursor]
Synonym EC 1.2.1.3
Gene name
Name: ALD1
Synonyms: ALDH, ALDH1
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2022618 [NCBI, ExPASy, EBI, Israel, Japan]
Saigal D., Cunningham S.J., Farres J., Weiner H.;
"Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation.";
J. Bacteriol. 173:3199-3208(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M57887; AAA34419.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A39410; A39410.
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase P22281.
Organism-specific databases
SGD S000029651; ALD1.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004029; Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016163; Ald_DHase_C.
IPR016160; Ald_DHase_CS.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
ProtoNet P22281.
Other
LinkHub P22281; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    21  21     Mitochondrion. 
CHAIN   22   533  512     Aldehyde dehydrogenase 1, mitochondrial. PRO_0000007163
NP_BIND   266   271  6     NAD (By similarity). 
ACT_SITE   289   289        By similarity. 
ACT_SITE   323   323        By similarity. 
Sequence information
Length: 533 AA [This is the length of the unprocessed precursor] Molecular weight: 59507 Da [This is the MW of the unprocessed precursor] CRC64: B5718E2328A21A0B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLATRNLVPI IRASIKWRIK LSALHYCMSD AETSEALLED NSAYINNEKH NLFLEKIFSD 

        70         80         90        100        110        120 
YQPFKHDNRT QVSCSQHMRD YRPLLTLSSA TRSVLFSLLA SDMSIILSIS PNTGILLCIG 

       130        140        150        160        170        180 
HLLASDIEDV VIVLSRGSPL VDLASTRIFK LAQNGTLRFA IKRTTFQELR FLRKSKDENV 

       190        200        210        220        230        240 
MEAATRGIIT IRQLYYENKV LPLRFTGNVA THIEENLEFE EQITWRTHVD SSIFPNTRCA 

       250        260        270        280        290        300 
YPSGYGPSAK IPCLSHKPND ILAYTGSTLV GRVVSKLAPE QVMKKVTLES GGKSTMAVFI 

       310        320        330        340        350        360 
QHDVTWAVEN TQFGVFDRQG QCCIAQSGYT VHRSTLSQIV ENNLEKDPSY VLHVDTESDI 

       370        380        390        400        410        420 
RGPFILKIHF ESIPRRINSA KAENSKVLCG GPRENSVYLY PTLSATLTDE CRIMKEEVFA 

       430        440        450        460        470        480 
PIITILCVKT VDEAIQRGNN SKFGLAAYVT KENVHGIILS TALKTVKLFI ICVHLASYQI 

       490        500        510        520        530 
PFGGNKNSGM GAELGKRALE NYTEGNHVLP VSLVKETLAP NTETASPARW PIH
P22281 in FASTA format

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