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UniProtKB/Swiss-Prot entry P22189


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATC3_SCHPO
Primary accession number P22189
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on August 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Calcium-transporting ATPase 3
Synonym EC 3.6.3.8
Gene name
Name: cta3
ORFNames: SPBC839.06, SPBC24E9.06
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2145281 [NCBI, ExPASy, EBI, Israel, Japan]
Ghislain M., Goffeau A., Halachmi D., Eilam Y.;
"Calcium homeostasis and transport are affected by disruption of cta3, a novel gene encoding Ca2(+)-ATPase in Schizosaccharomyces pombe.";
J. Biol. Chem. 265:18400-18407(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J05634; AAA35290.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CU329671; CAB46699.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A36096; A36096.
RefSeq NP_595246.1; -.
3D structure databases
HSSP P04191; 1EUL. [HSSP ENTRY / PDB]
ModBase P22189.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-003331-MON; -.
Organism-specific databases
GeneDB_Spombe SPBC839.06; -.
Gene expression databases
ArrayExpress P22189; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005388; Molecular function: calcium-transporting ATPase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006874; Biological process: cellular calcium ion homeostasis (traceable author statement from GeneDB_SPombe).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006414; ATPase-IID_KNa.
IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR000695; H_ATPase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00120; HATPASE.
TIGRFAMs TIGR01523; ATPase-IID_K-Na; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet P22189.
Genome annotation databases
GeneID 2541204; -.
KEGG spo:SPBC839.06; -.
NMPDR fig|4896.1.peg.1112; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Calcium; Calcium transport; Complete proteome; Hydrolase; Ion transport; Magnesium; Membrane; Nucleotide-binding; Phosphoprotein; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1037  1037     Calcium-transporting ATPase 3. PRO_0000046238
TRANSMEM   62     82  21     Potential. 
TRANSMEM   84    104  21     Potential. 
TRANSMEM   282    302  21     Potential. 
TRANSMEM   314    334  21     Potential. 
TRANSMEM   761    781  21     Potential. 
TRANSMEM   845    865  21     Potential. 
TRANSMEM   890    910  21     Potential. 
TRANSMEM   940    960  21     Potential. 
TRANSMEM   970    990  21     Potential. 
ACT_SITE   368    368        4-aspartylphosphate intermediate (By similarity). 
MOD_RES   1012   1012        Phosphoserine. 
Sequence information
Length: 1037 AA [This is the length of the unprocessed precursor] Molecular weight: 115327 Da [This is the MW of the unprocessed precursor] CRC64: 80D2BDF2292CE2B9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVTINISNPV YFSDIKDVES EFLTSIPNGL THEEAQNRLS EYGENRLEAD SGVSAWKVLL 

        70         80         90        100        110        120 
RQVLNAMCVV LILAAALSFG TTDWIEGGVI SAIIVLNITV GFIQEYKAEK TMDSLRTLAS 

       130        140        150        160        170        180 
PMAHVTRSSK TDAIDSHLLV PGDVVVLKTG DVVPADLRLV ETVNFETDEA LLTGESLPVI 

       190        200        210        220        230        240 
KDAHATFQMN EDVPIGDRIN LAYSSSIVTK GRAKGICYAT GMQTQIGAIA AGLRQKGKLF 

       250        260        270        280        290        300 
QRPEKDEPNY RRKLNKYYLK VTSYYVQRVL GLNVGTPLQR KLTVLAYILF CIAIILAIIV 

       310        320        330        340        350        360 
MAAHSFHVTN EVSIYAISLG ISIIPESLIA VLSITMAMGQ KNMSKRRVIV RKLEALEALG 

       370        380        390        400        410        420 
GVTDICSDKT GTITQGKMIT RRVWIPSYGY LSVDTSDANN PTIGTVSGLE AAMQDVLKEK 

       430        440        450        460        470        480 
KQEMKNIDPS NQPSDQFIPL LKTCALCNLS TVNQTETGEW VVKGEPTEIA LHVFSKRFNY 

       490        500        510        520        530        540 
GKEDLLKTNT FVREYPFDSE IKRMAVIYED QQGQYTVYAK GAVERILERC STSNGSTLEE 

       550        560        570        580        590        600 
PDRELIIAQM ETLAAEGLRV LALATKVIDK ADNWETLPRD VAESSLEFVS LVGIYDPPRT 

       610        620        630        640        650        660 
ESKGAVELCH RAGIRVHMLT GDHPETAKAI AREVGIIPPF ISDRDPNMSW MVMTGSQFDA 

       670        680        690        700        710        720 
LSDEEVDSLK ALCLVIARCA PQTKVKMIEA LHRRKAFVAM TGDGVNDSPS LKQANVGIAM 

       730        740        750        760        770        780 
GQNGSDVAKD ASDIVLTDDN FSSIVNAIEE GRRMFDNIMR FVLHLLVSNV GEVILLVVGL 

       790        800        810        820        830        840 
AFRDEVHLSV FPMSPVEILW CNMITSSFPS MGLGMELAQP DVMERLPHDN KVGIFQKSLI 

       850        860        870        880        890        900 
VDMMVYGFFL GVVSLMTWVV IMYGFGTGNL SYDCNAHYHA GCNDVFKARS AVFAVVTFCI 

       910        920        930        940        950        960 
LIMAVEVKNF DNSLFNLHGI PWGEWNFRYF LHTLVENKFL AWAIALAAVS VFPTIYIPVI 

       970        980        990       1000       1010       1020 
NRDVFKHTYI GWEWGVVAVA VMFYFFYVEI WKSIRRSLTN PQKKGKFRRT LSNTITTESK 

      1030 
LSEKDLEHRL FLQSRRA 

P22189 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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