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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 43-62.
STRAIN=74-ORS-6a / FGSC 4200;
DOI=10.1007/BF00321116; PubMed=2147127 [NCBI, ExPASy, EBI, Israel, Japan]
Preis D.,
van der Pas J.C.,
Nehls U.,
Roehlen D.-A.,
Sackmann U.,
Jahnke U.,
Weiss H.;
"The 49 K subunit of NADH: ubiquinone reductase (complex I) from Neurospora crassa mitochondria: primary structure of the gene and the protein.";
Curr. Genet. 18:59-64(1990).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E.,
Calvo S.E.,
Borkovich K.A.,
Selker E.U.,
Read N.D.,
Jaffe D.B.,
FitzHugh W.,
Ma L.-J.,
Smirnov S.,
Purcell S.,
Rehman B.,
Elkins T.,
Engels R.,
Wang S.,
Nielsen C.B.,
Butler J.,
Endrizzi M.,
Qui D.,
Ianakiev P., ![]()
Bell-Pedersen D.,
Nelson M.A.,
Werner-Washburne M.,
Selitrennikoff C.P.,
Kinsey J.A.,
Braun E.L.,
Zelter A.,
Schulte U.,
Kothe G.O.,
Jedd G.,
Mewes H.-W.,
Staben C.,
Marcotte E.,
Greenberg D.,
Roy A.,
Foley K.,
Naylor J.,
Stange-Thomann N.,
Barrett R.,
Gnerre S.,
Kamal M.,
Kamvysselis M.,
Mauceli E.W.,
Bielke C.,
Rudd S.,
Frishman D.,
Krystofova S.,
Rasmussen C.,
Metzenberg R.L.,
Perkins D.D.,
Kroken S.,
Cogoni C.,
Macino G.,
Catcheside D.E.A.,
Li W.,
Pratt R.J.,
Osmani S.A.,
DeSouza C.P.C.,
Glass N.L.,
Orbach M.J.,
Berglund J.A.,
Voelker R.,
Yarden O.,
Plamann M.,
Seiler S.,
Dunlap J.C.,
Radford A.,
Aramayo R.,
Natvig D.O.,
Alex L.A.,
Mannhaupt G.,
Ebbole D.J.,
Freitag M.,
Paulsen I.,
Sachs M.S.,
Lander E.S.,
Nusbaum C.,
Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
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- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD+ + ubiquinol.
- CATALYTIC ACTIVITY: NADH + acceptor = NAD+ + reduced acceptor.
- COFACTOR: Binds 1 4Fe-4S cluster.
- SUBUNIT: Complex I is composed of about 40 different subunits.
- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 478 AA [This is the length of the unprocessed precursor] |
Molecular weight: 54019 Da [This is the MW of the unprocessed precursor] |
CRC64: 159C35BE3DF9D916 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MATTLFRLAG RNAKRHCMRQ STTIAHNLNS TRAFSASALR RYAEPSYEGQ GTRLVPTGDD
70 80 90 100 110 120
FAPNNDLYGL EALKADGAPR VPPQDHILAR KVRHYTVNFG PQHPAAHGVL RLILELKGEE
130 140 150 160 170 180
IVRADPHVGL LHRGTEKLCE YRTYLQALPY FDRLDYVSMM TNEQCFALAV EKLLNVEIPE
190 200 210 220 230 240
RAKWIRTMFA EITRILNHLM SVLSHAMDVG ALTPFLWGFE EREKLMEFYE RVSGARLHAA
250 260 270 280 290 300
YVRPGGVHQD IPLGLLDDIY MWATQFGDRI DETEEMLTDN RIWIDRLRGI GVVSAADALN
310 320 330 340 350 360
LSFTGVMLRG SGVPWDIRKS QPYDAYDQVE FDVPVGINGD CYDRYLCRME EFRQSLRIIH
370 380 390 400 410 420
QCLNKMPAGP VRVEDYKISP PPRSAMKENM EALIHHFLLY TKGYAVPPGD TYSAIEAPKG
430 440 450 460 470
EMGVYVVSDG SERPYRVHIR APGFAHLGGF DHLSRGHMLA DAVAVIGTMD LVFGEVDR
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P22142 in FASTA format |
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