|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1016/0006-291X(89)91602-1; PubMed=2730663 [NCBI, ExPASy, EBI, Israel, Japan]
Sato M.,
Yoshida T.,
Tuboi S.;
"Primary structure of rat brain protein carboxyl methyltransferase deduced from cDNA sequence.";
Biochem. Biophys. Res. Commun. 161:342-347(1989).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8263531 [NCBI, ExPASy, EBI, Israel, Japan]
Mizobuchi M.,
Murao K.,
Takeda R.,
Kakimoto Y.;
"Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis.";
J. Neurochem. 62:322-328(1994).
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[4]
|
PROTEIN SEQUENCE OF 5-18; 28-37; 82-98; 106-135; 179-197 AND 205-219, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus, and Spinal cord;
Lubec G.,
Afjehi-Sadat L.,
Chen W.-Q.;
Submitted (APR-2007) to UniProtKB.
|
|
|
|
- FUNCTION: Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Cytoplasm.
- SIMILARITY: Belongs to the L-isoaspartyl/D-aspartyl protein methyltransferase family.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 227 AA [This is the length of the unprocessed precursor] |
Molecular weight: 24641 Da [This is the MW of the unprocessed precursor] |
CRC64: 833498527365E24F [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKSNPYMDSP QSIGFQATIS
70 80 90 100 110 120
APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GHSGKVIGID HIKELVDDSI
130 140 150 160 170 180
TNVKKDDPML LSSGRVRLVV GDGRMGFAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI
190 200 210 220
LPVGPAGGNQ MLEQYDKLQD GSVKMKPLMG VIYVPLTDKE KQWSRWK
|
P22062 in FASTA format |
|
ExPASy Home page
CBR Canada