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UniProtKB/Swiss-Prot entry P21948

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PPB_ESCFE
Primary accession number P21948
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on May 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Alkaline phosphatase [Precursor]
Synonyms APase
EC 3.1.3.1
Gene name
Name: phoA
From
Escherichia fergusonii [TaxID: 564] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 35469 / CDC 0568-73 / DSM 13698 / LMG 7866 / NCTC 12128;
PubMed=2129542 [NCBI, ExPASy, EBI, Israel, Japan]
Dubose R.F., Hartl D.L.;
"The molecular evolution of bacterial alkaline phosphatase: correlating variation among enteric bacteria to experimental manipulations of the protein.";
Mol. Biol. Evol. 7:547-577(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M33966; AAA24371.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I57445; I57445.
3D structure databases
HSSP P00634; 1AJC. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR P21948; 29-472.
ModBase P21948.
Ontologies
GO
GO:0042597; Cellular component: periplasmic space (inferred from electronic annotation from UniProtKB-KW).
GO:0004035; Molecular function: alkaline phosphatase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR017849; Alkaline_Pase-like_a/b/a.
IPR001952; Alkaline_phosphatase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.720.10; Alk_phosphtse; 1.
Pfam PF00245; Alk_phosphatase; 1.
Pfam graphical view of domain structure.
PRINTS PR00113; ALKPHPHTASE.
SMART SM00098; alkPPc; 1.
SMART graphical view of domain structure.
PROSITE PS00123; ALKALINE_PHOSPHATASE; 1.
ProtoNet P21948.
Other
LinkHub P21948; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Magnesium; Metal-binding; Periplasm; Phosphoprotein; Signal; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    21  21      
CHAIN   22   472  451     Alkaline phosphatase. PRO_0000024013
ACT_SITE   125   125        Phosphoserine intermediate (By similarity). 
METAL   74    74        Magnesium (By similarity). 
METAL   74    74        Zinc 2 (By similarity). 
METAL   176   176        Magnesium (By similarity). 
METAL   178   178        Magnesium (By similarity). 
METAL   345   345        Magnesium (By similarity). 
METAL   350   350        Zinc 1 (By similarity). 
METAL   354   354        Zinc 1 (By similarity). 
METAL   392   392        Zinc 2 (By similarity). 
METAL   393   393        Zinc 2 (By similarity). 
METAL   435   435        Zinc 1 (By similarity). 
DISULFID   191   201        By similarity. 
DISULFID   309   359        By similarity. 
Sequence information
Length: 472 AA [This is the length of the unprocessed precursor] Molecular weight: 49430 Da [This is the MW of the unprocessed precursor] CRC64: EF956C964F931141 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQSAIALAL LSCLITPVSQ AQTSQNINIL ENRAAQGDIT MPGGARRLSG DQTEALRASL 

        70         80         90        100        110        120 
NDKPAKNIIL LIGDGMGDSE ITAARNYAEG AGGYFKGIDA LPLTGQYTHY ALDKKTGKPD 

       130        140        150        160        170        180 
YVTDSAASAT AWTTGVKTYN GALGVDIHEN PHTTILEMAK AAGLATGNVS TAELQDATPA 

       190        200        210        220        230        240 
ALVSHVTSRK CYGPSVTSEK CPGNALEKGG KGSITEQLLN ARADVTLGGG AKTFAETATA 

       250        260        270        280        290        300 
GEWQGKTLRE QALARGYQIV SDAASLAAVT QAGQDKPLLG LFAEGNMPVR WHGPKASYHG 

       310        320        330        340        350        360 
NLDKPAVTCT PNPQRNETVP TLAQMTDKAI ELLSKNERGF FLQVEGASID KQDHAANPCG 

       370        380        390        400        410        420 
QIGETVDLDE AVQRALEFAK KDGNTLVIVT ADHAHSSQIV APDTKAPGLT QALNTKDGAV 

       430        440        450        460        470 
MAISYGNSEE DSQEHTGSQL RIAAYGPNAA NVVGLTDQTD LFYTMKAALG LQ
P21948 in FASTA format

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