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UniProtKB/Swiss-Prot entry P21932

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADCY3_RAT
Primary accession number P21932
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on May 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Adenylate cyclase type 3
Synonyms EC 4.6.1.1
Adenylate cyclase type III
AC-III
ATP pyrophosphate-lyase 3
Adenylyl cyclase 3
AC3
Adenylate cyclase, olfactive type
Gene name
Name: Adcy3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Olfactory epithelium;
PubMed=2255909 [NCBI, ExPASy, EBI, Israel, Japan]
Bakalyar H.A., Reed R.R.;
"Identification of a specialized adenylyl cyclase that may mediate odorant detection.";
Science 250:1403-1406(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M55075; AAA40677.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A39833; A39833.
RefSeq NP_570135.2; -.
UniGene Rn.87800
3D structure databases
HSSP P26769; 1AB8. [HSSP ENTRY / PDB]
ModBase P21932.
PTM databases
PhosphoSite P21932; -.
Organism-specific databases
RGD 71009; Adcy3.
Gene expression databases
ArrayExpress P21932; -.
GermOnline ENSRNOG00000003999; Rattus norvegicus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from EC).
GO:0005516; Molecular function: calmodulin binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
GO:0050896; Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007608; Biological process: sensory perception of smell (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 2.
Pfam PF00211; Guanylate_cyc; 2.
Pfam graphical view of domain structure.
SMART SM00044; CYCc; 2.
SMART graphical view of domain structure.
PROSITE PS00452; GUANYLATE_CYCLASE_1; 2.
PS50125; GUANYLATE_CYCLASE_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet P21932.
Genome annotation databases
Ensembl ENSRNOG00000003999; Rattus norvegicus. [Contig view]
GeneID 64508; -.
KEGG rno:64508; -.
Phylogenomic databases
HOVERGEN P21932; -.
Other
NextBio 613282; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calmodulin-binding; cAMP biosynthesis; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Olfaction; Repeat; Sensory transduction; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1144  1144     Adenylate cyclase type 3. PRO_0000195689
TOPO_DOM   1     79  79     Cytoplasmic (Potential). 
TRANSMEM   80    100  21     Potential. 
TRANSMEM   105    125  21     Potential. 
TRANSMEM   139    159  21     Potential. 
TRANSMEM   173    193  21     Potential. 
TRANSMEM   226    246  21     Potential. 
TRANSMEM   381    401  21     Potential. 
TOPO_DOM   402    630  229     Cytoplasmic (Potential). 
TRANSMEM   631    651  21     Potential. 
TRANSMEM   662    682  21     Potential. 
TRANSMEM   706    726  21     Potential. 
TRANSMEM   755    775  21     Potential. 
TRANSMEM   777    797  21     Potential. 
TRANSMEM   833    853  21     Potential. 
TOPO_DOM   854   1144  291     Cytoplasmic (Potential). 
METAL   324    324        Magnesium 1 (By similarity). 
METAL   324    324        Magnesium 2 (By similarity). 
METAL   325    325        Magnesium 2; via carbonyl oxygen (By similarity). 
METAL   368    368        Magnesium 1 (By similarity). 
METAL   368    368        Magnesium 2 (By similarity). 
CARBOHYD   734    734        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1144 AA [This is the length of the unprocessed precursor] Molecular weight: 128936 Da [This is the MW of the unprocessed precursor] CRC64: 21098D028DDBAB55 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTEDQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 

        70         80         90        100        110        120 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGVGLVLDII 

       130        140        150        160        170        180 
LFVLCKKGLL PDRVSRKVVP YLLWLLITAQ IFSYLGLNFS RAHAASDTVG WQAFFVFSFF 

       190        200        210        220        230        240 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 

       250        260        270        280        290        300 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 

       310        320        330        340        350        360 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 

       370        380        390        400        410        420 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 

       430        440        450        460        470        480 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 

       490        500        510        520        530        540 
YLDEKGIETY LIIASKPEVK KTAQNGLNGS ALPNGAPASK PSSPALIETK EPNGSAHASG 

       550        560        570        580        590        600 
STSEEAEEQE AQADNPSFPN PRRRLRLQDL ADRVVDASED EHELNQLLNE ALLERESAQV 

       610        620        630        640        650        660 
VKKRNTFLLT MRFMDPEMET RYSVEKEKQS GAAFSCSCVV LFCTAMVEIL IDPWLMTNYV 

       670        680        690        700        710        720 
TFVVGEVLLL ILTICSMAAI FPRAFPKKLV AFSSWIDRTR WARNTWAMLA IFILVMANVV 

       730        740        750        760        770        780 
DMLSCLQYYM GPYNVTTGIE LDGGCMENPK YYNYVAVLSL IATIMLVQVS HMVKLTLMLL 

       790        800        810        820        830        840 
VTGAVTAINL YAWCPVFDEY DHKRFQEKDS PMVALEKMQV LSTPGLNGTD SRLPLVPSKY 

       850        860        870        880        890        900 
SMTVMMFVMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 

       910        920        930        940        950        960 
ARHFLGSKKR DEELYSQSYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 

       970        980        990       1000       1010       1020 
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFTSSS KEEKSDKERW QHLADLADFA 

      1030       1040       1050       1060       1070       1080 
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 

      1090       1100       1110       1120       1130       1140 
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDRPAAFPN GSSVTLPHQV 


VDNP
P21932 in FASTA format

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