ID   G6PD_ZYMMO              Reviewed;         485 AA.
AC   P21907; Q5NQL3;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-NOV-2008, entry version 62.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=ZMO0367;
OS   Zymomonas mobilis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Zymomonas.
OX   NCBI_TaxID=542;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   MEDLINE=91072278; PubMed=2254282;
RA   Barnell W.O., Yi K.C., Conway T.;
RT   "Sequence and genetic organization of a Zymomonas mobilis gene cluster
RT   that encodes several enzymes of glucose metabolism.";
RL   J. Bacteriol. 172:7227-7240(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RA   Ahn J.Y., Kang H.S.;
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J.,
RA   Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M.,
RA   Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y.,
RA   Kang H.L., Lee S.Y., Lee K.J., Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; M60615; AAA27692.1; -; Genomic_DNA.
DR   EMBL; AF313764; AAG29865.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV88991.1; -; Genomic_DNA.
DR   PIR; B37855; B37855.
DR   RefSeq; YP_162102.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 3188588; -.
DR   GenomeReviews; AE008692_GR; ZMO0367.
DR   KEGG; zmo:ZMO0367; -.
DR   NMPDR; fig|264203.3.peg.863; -.
DR   HOGENOM; P21907; -.
DR   BioCyc; ZMOB264203:ZMO0367-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    485       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068138.
FT   ACT_SITE    236    236       Proton acceptor (By similarity).
FT   BINDING      14     14       NADP (By similarity).
FT   BINDING      46     46       NADP (By similarity).
FT   BINDING     174    174       Substrate (By similarity).
FT   BINDING     178    178       Substrate (By similarity).
SQ   SEQUENCE   485 AA;  53859 MW;  C326FC605ED92430 CRC64;
     MTNTVSTMIL FGSTGDLSQR MLLPSLYGLD ADGLLADDLR IVCTSRSEYD TDGFRDFAEK
     ALDRFVASDR LNDDAKAKFL NKLFYATVDI TDPTQFGKLA DLCGPVEKGI AIYLSTAPSL
     FEGAIAGLKQ AGLAGPTSRL ALEKPLGQDL ASSDHINDAV LKVFSEKQVY RIDHYLGKET
     VQNLLTLRFG NALFEPLWNS KGIDHVQISV AETVGLEGRI GYFDGSGSLR DMVQSHILQL
     VALVAMEPPA HMEANAVRDE KVKVFRALRP INNDTVFTHT VTGQYGAGVS GGKEVAGYID
     ELGQPSDTET FVAIKAHVDN WRWQGVPFYI RTGKRLPARR SEIVVQFKPV PHSIFSSSGG
     ILQPNKLRIV LQPDETIQIS MMVKEPGLDR NGAHMREVWL DLSLTDVFKD RKRRIAYERL
     MLDLIEGDAT LFVRRDEVEA QWVWIDGIRE GWKANSMKPK TYVSGTWGPS TAIALAERDG
     VTWYD
//