ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P21885


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name SPEA_BACSU
Primary accession number P21885
Secondary accession number P26934
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on December 1, 1992 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 78)
Name and origin of the protein
Protein name Arginine decarboxylase
Synonym EC 4.1.1.19
Gene name
Name: speA
Synonyms: cad
OrderedLocusNames: BSU14630
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
Hemilae H., Koivula T., Paulin L.;
"Cloning and sequencing the lysine decarboxylase of Bacillus subtilis.";
Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=8969500 [NCBI, ExPASy, EBI, Israel, Japan]
Winters P., Caldwell R.M., Enfield L., Ferrari E.;
"The ampS-nprE (124 degrees-127 degrees) region of the Bacillus subtilis 168 chromosome: sequencing of a 27 kb segment and identification of several genes in the area.";
Microbiology 142:3033-3037(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-490.
STRAIN=168;
PubMed=1697575 [NCBI, ExPASy, EBI, Israel, Japan]
Hemilae H.O., Palva A., Paulin L., Arvidson S., Palva I.;
"Secretory S complex of Bacillus subtilis: sequence analysis and identity to pyruvate dehydrogenase.";
J. Bacteriol. 172:5052-5063(1990).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 485-490.
DOI=10.1016/0378-1097(91)90417-9; PubMed=1936936 [NCBI, ExPASy, EBI, Israel, Japan]
Hemilae H.O.;
"Sequence of a PAL-related lipoprotein from Bacillus subtilis.";
FEMS Microbiol. Lett. 66:37-41(1991).
[6]
CHARACTERIZATION OF POLYAMINE PATHWAY.
PubMed=9723923 [NCBI, ExPASy, EBI, Israel, Japan]
Sekowska A., Bertin P., Danchin A.;
"Characterization of polyamine synthesis pathway in Bacillus subtilis 168.";
Mol. Microbiol. 29:851-858(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X58433; CAA41337.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF012285; AAC24937.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99111; CAB13336.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M57435; AAA62686.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A54546; A54546.
RefSeq NP_389346.1; -.
3D structure databases
ModBase P21885.
Enzyme and pathway databases
BioCyc BSUB224308:BSU1465-MON; -.
Organism-specific databases
SubtiList BG10212; speA. [Micado]
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0008792; Molecular function: arginine decarboxylase activity (inferred from electronic annotation from EC).
GO:0030170; Molecular function: pyridoxal phosphate binding (inferred from electronic annotation from InterPro).
GO:0009446; Biological process: putrescine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0008295; Biological process: spermidine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000310; Decarbxylse1.
IPR008286; Prn/Lys/Arg_de-COase_C.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.90.100.10; Decarbxylse_C; 1.
G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
Pfam PF01276; OKR_DC_1; 1.
PF03711; OKR_DC_1_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00703; OKR_DC_1; 1.
ProtoNet P21885.
Genome annotation databases
GeneID 936002; -.
GenomeReviews AL009126_GR; BSU14630.
KEGG bsu:BSU14630; -.
NMPDR fig|224308.1.peg.1465; -.
Phylogenomic databases
HOGENOM P21885; -.
Genome annotation databases
CMR P21885; BSU14630.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Decarboxylase; Lyase; Polyamine biosynthesis; Putrescine biosynthesis; Pyridoxal phosphate; Spermidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   490  490     Arginine decarboxylase. PRO_0000201147
BINDING   226   226        Pyridoxal phosphate (covalent) (By similarity). 
Sequence information
Length: 490 AA [This is the length of the unprocessed precursor] Molecular weight: 53583 Da [This is the MW of the unprocessed precursor] CRC64: 1AC7ACAE24F4F6D2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQHETPLYT GLKKHASRQP VQFHIPGHKK GAGMDPEFRQ FIGENALSID LINIEPLDDL 

        70         80         90        100        110        120 
HAPKGIIKQA QDLAAEAFGA DHTFFSVQGT SGAIMTMVMA VCGPGDKIII PRNVHKSIMT 

       130        140        150        160        170        180 
AIVFSGAVPI FIHPEIDNEL GISHGITLES AKRALTEHPD AKGLLVINPT YFGVAADLKS 

       190        200        210        220        230        240 
IVELAHSFDV PVLVDEAHGV HIHFHDELPL SAMQAGADIA ATSVHKLGGS LTQSSILNMR 

       250        260        270        280        290        300 
EGLVSKDRVQ SILSMLTTTS TSYLLLASLD VARKRLATEG RQLAEETLKL ANQTRDRLNQ 

       310        320        330        340        350        360 
IEGIYCVGSE ILGSKAAYSY DPTKLIISVK SLGLTGHDVE KWLRESFNIE VELSDLYNIL 

       370        380        390        400        410        420 
CIFTPGDSQN DADRLVEALT EIAQQMSEQD VTHQQTEVLL PEIPLLAMTP RDAFYANTEV 

       430        440        450        460        470        480 
IPLKEASGRI IAEFVMVYPP GIPIFIPGEI ITEENISYIF KNLDAGLPVQ GPEDSTLHMI 

       490 
RVIKEQKAIQ 

P21885 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!