[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 13048 / DSM 30053 / IFO 13534 / JCM 1235 / NCTC 10006; PubMed=2496104 [NCBI, ExPASy, EBI, Israel, Japan] Dahl M.K., Boos W., Manson M.D.; "Evolution of chemotactic-signal transducers in enteric bacteria."; J. Bacteriol. 171:2361-2371(1989).

Comments

FUNCTION: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either cheB or cheY (By similarity).
CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Contains 1 cheW-like domain.
SIMILARITY: Contains 1 histidine kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M26411; AAA24795.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A32302; A32302.

3D structure databases

HSSP

Q56310; 1I59. [HSSP ENTRY / PDB]

ModBase

P21813.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0000155;	Molecular function: two-component sensor activity (inferred from electronic annotation from InterPro).
GO:0006935;	Biological process: chemotaxis (inferred from electronic annotation from InterPro).
GO:0018106;	Biological process: peptidyl-histidine phosphorylation (inferred from electronic annotation from InterPro).
GO:0000160;	Biological process: two-component signal transduction system (phosphorelay) (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003594; ATP_bd_ATPase.
IPR002545; CheW.
IPR004358; Sig_transdc_His_kin-like_C.
IPR005467; Sig_transdc_His_kinase_core.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.565.10; ATP_bd_ATPase; 1.

Pfam

PF01584; CheW; 1.
PF02518; HATPase_c; 1.
Pfam graphical view of domain structure.

PRINTS

PR00344; BCTRLSENSOR.

SMART

SM00260; CheW; 1.
SM00387; HATPase_c; 1.
SMART graphical view of domain structure.

PROSITE

PS50851; CHEW; 1.
PS50109; HIS_KIN; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P21813.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chemotaxis; Cytoplasm; Kinase; Phosphoprotein; Transferase; Two-component regulatory system.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 226`	`>226`	`Chemotaxis protein cheA.`	`PRO_0000074713`
`DOMAIN`	`<1 82`	`>82`	`Histidine kinase.`
`DOMAIN`	`84 218`	`135`	`CheW-like.`
`NON_TER`	`1 1`

Sequence information

Length: 226 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 24186 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 948551B969D2D449 [This is a checksum on the sequence]

        10         20         30         40         50         60 
EKILAKAAAQ GLAVTDTMSD EEVGMLIFAP GFSTAEQVTD VSGRGVGMDV VKRNIQEMGG 

        70         80         90        100        110        120 
HVEIHSRAGK GTSIRILLPL TLAILDGMSV KVNEEVFILP LNAVMESLQP QREDLHPMAG 

       130        140        150        160        170        180 
GERMLQVRGE YLPLVELYRV FECAGAKTEA TQGIVVILQS AGRRNALLVD QLIGQHQCVK 

       190        200        210        220 
NLETNYRKVP GISAATILGD GSVALIVDVS ALQMLNREKL LSAAAA

P21813 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools