[1]	PROTEIN SEQUENCE. TISSUE=Venom; Mochca-Morales J., Martin B.M., Zamudio F.Z., Possani L.D.; "Isolation and characterization of three toxic phospholipases from the venom of the coral snake Micrurus nigrocinctus."; Toxicon 28:616-617(1990).

Comments

FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Acts presynaptically.
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
SIMILARITY: Belongs to the phospholipase A2 family. Group I subfamily.

Copyright

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Cross-references

Sequence databases
PIR	A35948; A35948.
3D structure databases
HSSP	P00598; 1POA. [HSSP ENTRY / PDB]
ModBase	P21790.
Family and domain databases
InterPro	IPR016090; Phospholipase_A2. IPR013090; Phospholipase_A2_AS. IPR001211; Phospholipase_A2_euk. Graphical view of domain structure.
Gene3D	G3DSA:1.20.90.10; Phospholipase_A2; 1.
PANTHER	PTHR11716; Phospholipase_A2; 1.
Pfam	PF00068; Phospholip_A2_1; 1. Pfam graphical view of domain structure.
PRINTS	PR00389; PHPHLIPASEA2.
ProDom	PD000303; PhospholipaseA2; 1. [Domain structure / List of seq. sharing at least 1 domain]
PROSITE	PS00119; PA2_ASP; PARTIAL. PS00118; PA2_HIS; PARTIAL.
BLOCKS	P21790.
Phylogenomic databases
HOVERGEN	P21790; -.
Other
ProtoNet	P21790.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Neurotoxin; Presynaptic neurotoxin; Secreted; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >27`	`>27`	`Phospholipase A2 isozyme 1.`	`PRO_0000161658`
`NON_TER`	`27 27`

Sequence information

Length: 27 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 3314 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 38637ECA600F49A0 [This is a checksum on the sequence]

        10         20 
NLYQFKNMIQ CTTKRSVLEF MEYGCYC

P21790 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools