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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZP3A).
PubMed=2385582 [NCBI, ExPASy, EBI, Israel, Japan]
Chamberlin M.E.,
Dean J.;
"Human homolog of the mouse sperm receptor.";
Proc. Natl. Acad. Sci. U.S.A. 87:6014-6018(1990).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ZP3A AND ZP3B).
TISSUE=Ovary;
DOI=10.1016/S0888-7543(05)80130-2; PubMed=1478648 [NCBI, ExPASy, EBI, Israel, Japan]
van Duin M.,
Polman J.E.,
Verkoelen C.C.,
Bunschoten H.,
Meyerink J.H.,
Olijve W.,
Aitken R.J.;
"Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations.";
Genomics 14:1064-1070(1992).
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- FUNCTION: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
- SUBUNIT: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity).
- SUBCELLULAR LOCATION: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix.
- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | ZP3B |
| Isoform ID | P21754-2 |
| Note: Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids. |
| Features which should be applied to build the isoform sequence: VSP_006949, VSP_006950. |
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- TISSUE SPECIFICITY: Oocytes.
- DOMAIN: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
- PTM: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
- PTM: N-glycosylated (By similarity).
- PTM: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy (By similarity).
- SIMILARITY: Belongs to the ZP domain family. ZPC subfamily.
- SIMILARITY: Contains 1 ZP domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 424 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47029 Da [This is the MW of the unprocessed precursor] |
CRC64: 94517B7B66EFFE06 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF
70 80 90 100 110 120
GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP
130 140 150 160 170 180
RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN
190 200 210 220 230 240
WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL
250 260 270 280 290 300
VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC
310 320 330 340 350 360
SFSKPSNSWF PVEGPADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV
370 380 390 400 410 420
TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV
SASE
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P21754 in FASTA format |
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ExPASy Home page
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