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UniProtKB/Swiss-Prot entry P21741


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MK_HUMAN
Primary accession number P21741
Secondary accession number Q9UCC7
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on May 1, 1991 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 89)
Name and origin of the protein
Protein name Midkine [Precursor]
Synonyms MK
Neurite outgrowth-promoting protein
Midgestation and kidney protein
Amphiregulin-associated protein
ARAP
Neurite outgrowth-promoting factor 2
Gene name
Name: MDK
Synonyms: MK1, NEGF2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
DOI=10.1016/S0006-291X(05)80255-4; PubMed=2025291 [NCBI, ExPASy, EBI, Israel, Japan]
Tsutsui J., Uehara K., Kadomatsu K., Matsubara S., Muramatsu T.;
"A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.";
Biochem. Biophys. Res. Commun. 176:792-797(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
TISSUE=Fetal brain;
PubMed=1768439 [NCBI, ExPASy, EBI, Israel, Japan]
Kretschmer P.J., Fairhurst J.L., Decker M.M., Chan C.P., Gluzman Y., Boehlen P., Kovesdi I.;
"Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.";
Growth Factors 5:99-114(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1639750 [NCBI, ExPASy, EBI, Israel, Japan]
Uehara K., Matsubara S., Kadomatsu K., Tsutsui J., Muramatsu T.;
"Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor.";
J. Biochem. 111:563-567(1992).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Fetal brain;
DOI=10.1089/dna.1993.12.139; PubMed=8471163 [NCBI, ExPASy, EBI, Israel, Japan]
Fairhurst J.L., Kretschmer P.J., Gluzman Y., Boehlen P., Kovesdi I.;
"Structure of the gene coding for the human retinoic acid-inducible factor, MK.";
DNA Cell Biol. 12:139-147(1993).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 21-143.
DOI=10.1016/0006-291X(91)91409-6; PubMed=1883381 [NCBI, ExPASy, EBI, Israel, Japan]
Shoyab M., McDonald V.L., Dick K., Modrell B., Malik N., Plowman G.D.;
"Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7.";
Biochem. Biophys. Res. Commun. 179:572-578(1991).
[7]
PROTEIN SEQUENCE OF 21-35, AND INDUCTION.
TISSUE=Plasma;
PubMed=8241100 [NCBI, ExPASy, EBI, Israel, Japan]
Novotny W.F., Maffi T., Mehta R.L., Milner P.G.;
"Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma.";
Arterioscler. Thromb. 13:1798-1805(1993).
[8]
PROTEIN SEQUENCE OF 21-35.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[9]
STRUCTURE BY NMR OF 23-81 AND 84-126, AND HOMODIMERIZATION.
DOI=10.1093/emboj/16.23.6936; PubMed=9384573 [NCBI, ExPASy, EBI, Israel, Japan]
Iwasaki W., Nagata K., Hatanaka H., Inui T., Kimura T., Muramatsu T., Yoshida K., Tasumi M., Inagaki F.;
"Solution structure of midkine, a new heparin-binding growth factor.";
EMBO J. 16:6936-6946(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M69148; AAA58478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55110; CAA38908.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D10604; BAA01457.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M94250; AAA59850.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011704; AAH11704.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00010333; -.
PIR JH0385; JH0385.
RefSeq NP_001012333.1; -.
NP_001012334.1; -.
NP_002382.1; -.
UniGene Hs.82045
3D structure databases
PDB
1MKC; NMR; -; A=84-126.[ExPASy / RCSB / EBI]
1MKN; NMR; -; A=23-81.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1MKC; -.
1MKN; -.
ModBase P21741.
Protein-protein interaction databases
DIP DIP:5789N; -.
IntAct P21741; 2.
Enzyme and pathway databases
Pathway_Interaction_DB glypican_2pathway; Glypican 2 network.
syndecan_4_pathway; Syndecan-4-mediated signaling events.
Organism-specific databases
GeneCards GC11P046359; -.
H-InvDB HIX0009601; -.
HGNC HGNC:6972; MDK.
GenAtlas MDK.
HPA CAB010055; -.
MIM 162096; gene. [NCBI / EBI]
PharmGKB PA30717; -.
Gene expression databases
ArrayExpress P21741; -.
Bgee P21741; -.
CleanEx HS_MDK; -.
GermOnline ENSG00000110492; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008083; Molecular function: growth factor activity (non-traceable author statement from UniProtKB).
GO:0008201; Molecular function: heparin binding (inferred from direct assay from UniProtKB).
GO:0030325; Biological process: adrenal gland development (inferred from sequence or structural similarity from UniProtKB).
GO:0030154; Biological process: cell differentiation (non-traceable author statement from UniProtKB).
GO:0008283; Biological process: cell proliferation (inferred from electronic annotation from UniProtKB-KW).
GO:0007399; Biological process: nervous system development (non-traceable author statement from UniProtKB).
GO:0009611; Biological process: response to wounding (inferred from sequence or structural similarity from UniProtKB).
GO:0007165; Biological process: signal transduction (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000762; PTN_MK_hepar_bd.
Graphical view of domain structure.
Gene3D G3DSA:2.20.60.10; PTN_MK_hepar_bd; 1.
G3DSA:2.30.90.10; PTN_MK_hepar_bd; 1.
PANTHER PTHR13850; PTN_MK_hepar_bd; 1.
Pfam PF01091; PTN_MK_C; 1.
PF05196; PTN_MK_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00269; PTNMIDKINE.
ProDom PD005592; PTN_MK; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00193; PTN; 1.
SMART graphical view of domain structure.
PROSITE PS00619; PTN_MK_1; 1.
PS00620; PTN_MK_2; 1.
Proteomic databases
PRIDE P21741; -.
Genome annotation databases
Ensembl ENSG00000110492; Homo sapiens. [Contig view]
GeneID 4192; -.
KEGG hsa:4192; -.
Phylogenomic databases
HOGENOM P21741; -.
HOVERGEN P21741; -.
OMA P21741; FREGTCG.
Other
NextBio 16518; -.
SOURCE MDK; Homo sapiens.
ProtoNet P21741.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Growth factor; Heparin-binding; Mitogen; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    20  20      
CHAIN   21   143  123     Midkine. PRO_0000024662
DISULFID   37    61         
DISULFID   45    70         
DISULFID   52    74         
DISULFID   84   116         
DISULFID   94   126         
VARIANT   21    22  2     Missing (in 35% of the chains). VAR_006353
STRAND   29    31  3      
STRAND   38    43  6      
STRAND   48    54  7      
STRAND   57    63  7      
STRAND   66    68  3      
STRAND   76    79  4      
STRAND   96   100  5      
STRAND   111   115  5      
STRAND   118   120  3      
Sequence information
Length: 143 AA [This is the length of the unprocessed precursor] Molecular weight: 15585 Da [This is the MW of the unprocessed precursor] CRC64: 414A627FF39953C3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT 

        70         80         90        100        110        120 
CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI 

       130        140 
RVTKPCTPKT KAKAKAKKGK GKD 

P21741 in FASTA format

View entry in raw text format (no links)
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