ID   6PGD_SYNE7              Reviewed;         471 AA.
AC   P21577; Q31S98;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 4.
DT   25-NOV-2008, entry version 61.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
GN   Name=gnd; OrderedLocusNames=Synpcc7942_0039;
OS   Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBSTRATE-BINDING SITE.
RX   MEDLINE=90299831; PubMed=2113917;
RA   Broedel S.E. Jr., Wolf R.E. Jr.;
RT   "Genetic tagging, cloning, and DNA sequence of the Synechococcus sp.
RT   strain PCC 7942 gene (gnd) encoding 6-phosphogluconate
RT   dehydrogenase.";
RL   J. Bacteriol. 172:4023-4031(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Culler D.C., Krogmann D.W.;
RT   "Amino acid sequence comparisons of 6-phosphogluconate
RT   dehydrogenase.";
RL   Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC
RT   7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; M55002; AAA27330.1; -; Genomic_DNA.
DR   EMBL; X58719; CAA41555.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB56071.1; -; Genomic_DNA.
DR   PIR; S14628; S14628.
DR   RefSeq; YP_399058.1; -.
DR   HSSP; P00349; 2PGD.
DR   GeneID; 3775852; -.
DR   GenomeReviews; CP000100_GR; Synpcc7942_0039.
DR   KEGG; syf:Synpcc7942_0039; -.
DR   HOGENOM; P21577; -.
DR   BioCyc; SELO1140:SYNPCC7942_0039-MON; -.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:InterPro.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   InterPro; IPR006183; 6-phosphogluconate_DHase.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Gluconate utilization; NADP; Oxidoreductase;
KW   Pentose shunt.
FT   CHAIN         1    471       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090060.
FT   CONFLICT    154    159       EPIVRS -> SRSVPT (in Ref. 1; AAA27330).
FT   CONFLICT    159    159       S -> T (in Ref. 2; CAA41555).
FT   CONFLICT    407    407       A -> R (in Ref. 2; CAA41555).
FT   CONFLICT    415    439       AAERGIPVPAFSASLDYFDSYRRDR -> RQNEEFRFRFQC
FT                                FPGLLRQLPARS (in Ref. 2; CAA41555).
FT   CONFLICT    437    441       RDRLP -> ASPA (in Ref. 1; AAA27330).
FT   CONFLICT    450    453       DYFG -> TTC (in Ref. 1).
FT   CONFLICT    458    465       ERTDRSGS -> KAPIALL (in Ref. 1;
FT                                AAA27330).
FT   CONFLICT    469    470       QW -> M (in Ref. 1).
SQ   SEQUENCE   471 AA;  51073 MW;  0C75D58209E124E7 CRC64;
     MALQQFGLIG LAVMGENLAL NIERNGFSLT VYNRTAEKTE AFMADRAQGK NIVPAYSLED
     FVASLERPRR ILVMVKAGGP VDAVVEQLKP LLDPGDLIID GGNSLFTDTE RRVKDLEALG
     LGFMGMGVSG GEEGALNGPS LMPGGTQAAY EAVEPIVRSI AAQVDDGPCV TYIGPGGSGH
     YVKMVHNGIE YGDMQLIAEA YDLLKSVAGL NASELHDVFA AWNKTPELDS FLIEITADIF
     TKVDDLGTGQ PLVELILDAA GQKGTGRWTV ETALEIGVAI PTIIAAVNAR ILSSIKAERQ
     AASEILSGPI TEPFSGDRQA FIDSVRDALY CSKICSYAQG MALLAKASQV YNYGLNLGEL
     ARIWKGGCII RAGFLNKIKQ AYDADPTLAN LLLAPEFRQT ILDRQLAWRR VIAIAAERGI
     PVPAFSASLD YFDSYRRDRL PQNLTQAQRD YFGAHTYERT DRSGSFHAQW F
//