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UniProtKB/Swiss-Prot entry P21189


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPO2_ECOLI
Primary accession number P21189
Secondary accession numbers Q8KMX7 Q8KMX8
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 86)
Name and origin of the protein
Protein name DNA polymerase II
Synonyms Pol II
EC 2.7.7.7
Gene name
Name: polB
Synonyms: dinA
OrderedLocusNames: b0060, JW0059
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-9.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1007/BF00273583; PubMed=2034216 [NCBI, ExPASy, EBI, Israel, Japan]
Iwasaki H., Ishino Y., Toh H., Nakata A., Shinagawa H.;
"Escherichia coli DNA polymerase II is homologous to alpha-like DNA polymerases.";
Mol. Gen. Genet. 226:24-33(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=2261080 [NCBI, ExPASy, EBI, Israel, Japan]
Chen H., Sun Y., Stark T., Beattie W., Moses R.E.;
"Nucleotide sequence and deletion analysis of the polB gene of Escherichia coli.";
DNA Cell Biol. 9:631-635(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12;
DOI=10.1093/nar/20.13.3305; PubMed=1630901 [NCBI, ExPASy, EBI, Israel, Japan]
Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.;
"Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.";
Nucleic Acids Res. 20:3305-3308(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-458, AND PROTEIN SEQUENCE OF 2-28.
STRAIN=K12;
PubMed=2217198 [NCBI, ExPASy, EBI, Israel, Japan]
Bonner C.A., Hays S., McEntee K., Goodman M.F.;
"DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 87:7663-7667(1990).
[7]
VARIANT MUTANT ALLELE POLB100.
DOI=10.1074/jbc.272.13.8611; PubMed=9079692 [NCBI, ExPASy, EBI, Israel, Japan]
Qiu Z., Goodman M.F.;
"The Escherichia coli polB locus is identical to dinA, the structural gene for DNA polymerase II. Characterization of Pol II purified from a polB mutant.";
J. Biol. Chem. 272:8611-8617(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X54847; CAA38616.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M62646; AAA24406.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M35371; AAA24407.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M38283; AAA63764.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC73171.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAB96628.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M37727; AAA23684.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S15943; JDEC22.
RefSeq AP_000724.1; -.
NP_414602.1; -.
3D structure databases
PDB
1Q8I; X-ray; 2.00 A; A=1-783.[ExPASy / RCSB / EBI]
PDBsum 1Q8I; -.
ModBase P21189.
Protein-protein interaction databases
IntAct P21189; -.
Enzyme and pathway databases
BioCyc EcoCyc:EG10747-MON; -.
Organism-specific databases
EchoBASE EB0740; -.
EcoGene EG10747; polB.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR006172; DNA-dir_DNA_pol_B.
IPR006134; DNA-dir_DNA_pol_B_cons-reg.
IPR006133; DNA-dir_DNA_pol_B_exonuc.
Graphical view of domain structure.
PANTHER PTHR10322; DNA_pol_B; 1.
Pfam PF00136; DNA_pol_B; 2.
PF03104; DNA_pol_B_exo; 1.
Pfam graphical view of domain structure.
PRINTS PR00106; DNAPOLB.
SMART SM00486; POLBc; 1.
SMART graphical view of domain structure.
PROSITE PS00116; DNA_POLYMERASE_B; 1.
BLOCKS P21189.
Genome annotation databases
GeneID 944779; -.
GenomeReviews U00096_GR; b0060.
AP009048_GR; JW0059.
KEGG ecj:JW0059; -.
eco:b0060; -.
Phylogenomic databases
HOGENOM P21189; -.
Genome annotation databases
CMR P21189; b0060.
Other
ProtoNet P21189.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; SOS response; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   783  782     DNA polymerase II. PRO_0000046473
VARIANT   401   401  1     G -> D (in allele POLB100). 
CONFLICT   172   172        G -> A (in Ref. 2; AAA24406/AAA24407). 
CONFLICT   257   258        EH -> DD (in Ref. 6; AAA63764/AAA23684). 
CONFLICT   272   272        R -> G (in Ref. 6; AAA63764/AAA23684). 
CONFLICT   735   735        N -> T (in Ref. 2; AAA24406/AAA24407). 
CONFLICT   740   783        LDYQRSPLDYEHYLTRQLQPVAEGILPFIEDNFATLMTG QLGLF -> PGLPTFTTGLRTLSDPPATTRGGGNTPFY (in Ref. 2). 
STRAND   3    13  11      
STRAND   19    27  9      
STRAND   30    35  6      
STRAND   41    46  6      
HELIX   47    49  3      
HELIX   50    56  7      
TURN   57    59  3      
STRAND   62    71  10      
STRAND   77    84  8      
HELIX   86    98  13      
HELIX   110   117  8      
STRAND   121   131  11      
STRAND   134   142  9      
STRAND   152   159  8      
STRAND   165   172  8      
STRAND   175   183  9      
STRAND   192   200  9      
HELIX   201   215  15      
STRAND   218   224  7      
TURN   225   228  4      
HELIX   229   239  11      
STRAND   247   250  4      
STRAND   254   258  5      
STRAND   260   262  3      
STRAND   264   269  6      
STRAND   272   276  5      
HELIX   277   283  7      
HELIX   293   298  6      
HELIX   316   323  8      
HELIX   325   346  22      
HELIX   348   359  12      
TURN   363   366  4      
HELIX   369   383  15      
STRAND   410   420  11      
HELIX   423   431  9      
HELIX   435   443  9      
TURN   447   449  3      
STRAND   450   452  3      
STRAND   458   463  6      
HELIX   466   482  17      
HELIX   486   503  18      
HELIX   513   536  24      
STRAND   540   544  5      
STRAND   546   552  7      
HELIX   559   582  24      
TURN   583   585  3      
STRAND   592   603  12      
STRAND   617   623  7      
STRAND   626   634  9      
HELIX   643   657  15      
HELIX   663   674  12      
TURN   675   678  4      
HELIX   679   682  4      
HELIX   749   755  7      
HELIX   757   762  6      
HELIX   765   768  4      
HELIX   772   780  9      
Sequence information
Length: 783 AA [This is the length of the unprocessed precursor] Molecular weight: 90053 Da [This is the MW of the unprocessed precursor] CRC64: 1A12A21B2FDB0E22 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAQAGFILTR HWRDTPQGTE VSFWLATDNG PLQVTLAPQE SVAFIPADQV PRAQHILQGE 

        70         80         90        100        110        120 
QGFRLTPLAL KDFHRQPVYG LYCRAHRQLM NYEKRLREGG VTVYEADVRP PERYLMERFI 

       130        140        150        160        170        180 
TSPVWVEGDM HNGTIVNARL KPHPDYRPPL KWVSIDIETT RHGELYCIGL EGCGQRIVYM 

       190        200        210        220        230        240 
LGPENGDASS LDFELEYVAS RPQLLEKLNA WFANYDPDVI IGWNVVQFDL RMLQKHAERY 

       250        260        270        280        290        300 
RLPLRLGRDN SELEWREHGF KNGVFFAQAK GRLIIDGIEA LKSAFWNFSS FSLETVAQEL 

       310        320        330        340        350        360 
LGEGKSIDNP WDRMDEIDRR FAEDKPALAT YNLKDCELVT QIFHKTEIMP FLLERATVNG 

       370        380        390        400        410        420 
LPVDRHGGSV AAFGHLYFPR MHRAGYVAPN LGEVPPHASP GGYVMDSRPG LYDSVLVLDY 

       430        440        450        460        470        480 
KSLYPSIIRT FLIDPVGLVE GMAQPDPEHS TEGFLDAWFS REKHCLPEIV TNIWHGRDEA 

       490        500        510        520        530        540 
KRQGNKPLSQ ALKIIMNAFY GVLGTTACRF FDPRLASSIT MRGHQIMRQT KALIEAQGYD 

       550        560        570        580        590        600 
VIYGDTDSTF VWLKGAHSEE EAAKIGRALV QHVNAWWAET LQKQRLTSAL ELEYETHFCR 

       610        620        630        640        650        660 
FLMPTIRGAD TGSKKRYAGL IQEGDKQRMV FKGLETVRTD WTPLAQQFQQ ELYLRIFRNE 

       670        680        690        700        710        720 
PYQEYVRETI DKLMAGELDA RLVYRKRLRR PLSEYQRNVP PHVRAARLAD EENQKRGRPL 

       730        740        750        760        770        780 
QYQNRGTIKY VWTTNGPEPL DYQRSPLDYE HYLTRQLQPV AEGILPFIED NFATLMTGQL 


GLF 

P21189 in FASTA format

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