[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1016/0042-6822(90)90294-2; PubMed=2219722 [NCBI, ExPASy, EBI, Israel, Japan] Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.; "The complete DNA sequence of vaccinia virus."; Virology 179:247-266(1990).
[2]	COMPLETE GENOME. Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.; "Appendix to 'The complete DNA sequence of vaccinia virus'."; Virology 179:517-563(1990).

Comments

FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CATALYTIC ACTIVITY: ATP + RNA(n) = diphosphate + RNA(n+1).
SUBUNIT: Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.
SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M35027; AAA48038.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E42508; E42508.

3D structure databases

SMR

P21079; 12-479.

ModBase

P21079.

Ontologies

GO:0004652;	Molecular function: polynucleotide adenylyltransferase activity (inferred from electronic annotation from InterPro).
GO:0006397;	Biological process: mRNA processing (inferred from electronic annotation from InterPro).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR004976; PolyA_pol_cat_poxviral.
Graphical view of domain structure.

Pfam

PF03296; Pox_polyA_pol; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF015693; VAC-48L_nuct; 1.

ProtoNet

P21079.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; mRNA processing; Transcription; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 479`	`479`	`Poly(A) polymerase catalytic subunit.`	`PRO_0000099106`
`ACT_SITE`	`202 202`		`By similarity.`
`ACT_SITE`	`204 204`		`By similarity.`

Sequence information

Length: 479 AA [This is the length of the unprocessed precursor]

Molecular weight: 55580 Da [This is the MW of the unprocessed precursor]

CRC64: 50AC0C13698BECA7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNRNPDQNTF PNITLKIIET YLGRVPSVNE YHMLKLQARN IQKITVFNKD IFVSLVKKNK 

        70         80         90        100        110        120 
KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL QSVLVTTYTD ILGVLTIKAP 

       130        140        150        160        170        180 
NVISSKISYN VTSMEELARD MLNSMNVAII DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN 

       190        200        210        220        230        240 
KSCICYGSYS LYLINPNIRY GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY 

       250        260        270        280        290        300 
MVIKDENDNH IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 

       310        320        330        340        350        360 
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD YFSFKKCLVY 

       370        380        390        400        410        420 
LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF SNTILLSDKG KVHEISARGL 

       430        440        450        460        470 
CAHILLYQML TSGEYKQCLS DLLNSMMNRD KIPIYSHTER DKKPGRHGFI NIEKDIIVF

P21079 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools