[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Placenta;
DOI=10.1126/science.3201259; PubMed=3201259 [NCBI, ExPASy, EBI, Israel, Japan]
Trahey M.,
Wong G.,
Halenbeck R.,
Rubinfeld B.,
Martin G.A.,
Ladner M.,
Long C.M.,
Crosier W.J.,
Watt K.,
Koths K.,
McCormick F.;
"Molecular cloning of two types of GAP complementary DNA from human placenta.";
Science 242:1697-1700(1988).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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PROTEIN SEQUENCE OF 294-303; 326-334; 392-398; 439-457; 458-466; 479-483; 777-790 AND 821-825.
PubMed=8360177 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Y.,
Zhang G.,
Mollat P.,
Carles C.,
Riva M.,
Frobert Y.,
Malassine A.,
Rostene W.,
Thang D.C.,
Beltchev B.,
Tavitian A.,
Thane M.N.;
"Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein.";
J. Biol. Chem. 268:18875-18881(1993).
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[5]
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PROTEIN SEQUENCE OF 1-7 (ISOFORM 2).
PubMed=2123878 [NCBI, ExPASy, EBI, Israel, Japan]
Halenbeck R.,
Crosier W.J.,
Clark R.,
McCormick F.,
Koths K.;
"Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources.";
J. Biol. Chem. 265:21922-21928(1990).
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[6]
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INTERACTION WITH SQSTM1.
DOI=10.1073/pnas.92.26.12338; PubMed=8618896 [NCBI, ExPASy, EBI, Israel, Japan]
Park I.,
Chung J.,
Walsh C.T.,
Yun Y.,
Strominger J.L.,
Shin J.;
"Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.";
Proc. Natl. Acad. Sci. U.S.A. 92:12338-12342(1995).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-615, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[8]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-615, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[9]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[10]
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STRUCTURE BY NMR OF 275-350.
PubMed=8137811 [NCBI, ExPASy, EBI, Israel, Japan]
Yang Y.S.,
Garbay C.,
Duschesne M.,
Cornille F.,
Jullian N.,
Fromage N.,
Tocque B.,
Roques B.P.;
"Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.";
EMBO J. 13:1270-1279(1994).
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[11]
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X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 714-1047.
DOI=10.1038/384591a0; PubMed=8955277 [NCBI, ExPASy, EBI, Israel, Japan]
Scheffzek K.,
Lautwein A.,
Kabsch W.,
Reza Ahmadian M.,
Wittinghofer A.;
"Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.";
Nature 384:591-596(1996).
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[12]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 714-1047 IN COMPLEX WITH RAS.
DOI=10.1126/science.277.5324.333; PubMed=9219684 [NCBI, ExPASy, EBI, Israel, Japan]
Scheffzek K.,
Ahmadian M.R.,
Kabsch W.,
Wiesmuller L.,
Lautwein A.,
Schmitz F.,
Wittinghofer A.;
"The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.";
Science 277:333-338(1997).
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[13]
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STRUCTURE BY NMR OF 282-446.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the SH3 domain and of the second SH2 domain of human RAS GTPase-activating protein 1.";
Submitted (MAY-2007) to the PDB data bank.
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[14]
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VARIANTS LEU-398; GLU-400 AND VAL-401.
DOI=10.1038/ng1193-242; PubMed=8275088 [NCBI, ExPASy, EBI, Israel, Japan]
Friedman E.,
Gejman P.V.,
Martin G.A.,
McCormick F.;
"Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.";
Nat. Genet. 5:242-247(1993).
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[15]
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VARIANT CMAVM TYR-540.
DOI=10.1086/379793; PubMed=14639529 [NCBI, ExPASy, EBI, Israel, Japan]
Eerola I.,
Boon L.M.,
Mulliken J.B.,
Burrows P.E.,
Dompmartin A.,
Watanabe S.,
Vanwijck R.,
Vikkula M.;
"Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations.";
Am. J. Hum. Genet. 73:1240-1249(2003).
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[16]
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INTERACTION WITH SPSB1.
DOI=10.1074/jbc.M413897200; PubMed=15713673 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D.,
Li Z.,
Messing E.M.,
Wu G.;
"The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.";
J. Biol. Chem. 280:16393-16401(2005).
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