ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P20151


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name KLK2_HUMAN
Primary accession number P20151
Secondary accession numbers Q15946 Q9UJZ9
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on February 1, 1991 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 96)
Name and origin of the protein
Protein name Kallikrein-2 [Precursor]
Synonyms EC 3.4.21.35
Tissue kallikrein-2
Glandular kallikrein-1
hGK-1
Gene name
Name: KLK2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
PubMed=2824146 [NCBI, ExPASy, EBI, Israel, Japan]
Schedlich L.J., Bennetts B.H., Morris B.J.;
"Primary structure of a human glandular kallikrein gene.";
DNA 6:429-437(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Prostate;
DOI=10.1016/0303-7207(91)90272-T; PubMed=1726490 [NCBI, ExPASy, EBI, Israel, Japan]
Riegman P.H., Vlietstra R.J., der Korput H.A., Romijn J.C., Trapman J.;
"Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.";
Mol. Cell. Endocrinol. 76:181-190(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
DOI=10.1006/bbrc.1999.1595; PubMed=10544017 [NCBI, ExPASy, EBI, Israel, Japan]
Liu X.F., Essand M., Vasmatzis G., Lee B., Pastan I.;
"Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.";
Biochem. Biophys. Res. Commun. 264:833-839(1999).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0378-1119(00)00382-6; PubMed=11054574 [NCBI, ExPASy, EBI, Israel, Japan]
Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.;
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.";
Gene 257:119-130(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T., Green R.E., Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
[9]
VARIANT LEU-18.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
[10]
ERRATUM.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
Nat. Genet. 23:373-373(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M18156; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
M18157; AAA74454.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S39329; AAD13816.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S39329; AAD13817.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF188745; AAF08275.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF188746; AAF08276.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF188747; AAF08277.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF243527; AAG33356.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006650; AAP35296.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC037199; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC005196; AAH05196.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00022227; -.
IPI00219231; -.
IPI00434943; -.
PIR A29586; A29586.
RefSeq NP_001002231.1; -.
NP_005542.1; -.
UniGene Hs.515560
3D structure databases
HSSP P00760; 1EZX. [HSSP ENTRY / PDB]
ModBase P20151.
Protein family/group databases
MEROPS S01.161; -.
PTM databases
PhosphoSite P20151; -.
Enzyme and pathway databases
BRENDA 3.4.21.35; 247.
Pathway_Interaction_DB ar_pathway; Coregulation of Androgen receptor activity.
ar_tf_pathway; Regulation of Androgen receptor activity.
Organism-specific databases
GeneCards GC19P056068; -.
H-InvDB HIX0015370; -.
HGNC HGNC:6363; KLK2.
GenAtlas KLK2.
HPA HPA000764; -.
MIM 147960; gene. [NCBI / EBI]
PharmGKB PA30152; -.
Gene expression databases
ArrayExpress P20151; -.
Bgee P20151; -.
CleanEx HS_KLK2; -.
GermOnline ENSG00000167751; Homo sapiens.
Ontologies
GO
GO:0004252; Molecular function: serine-type endopeptidase activity (traceable author statement from ProtInc).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P20151; -.
Genome annotation databases
Ensembl ENSG00000167751; Homo sapiens. [Contig view]
GeneID 3817; -.
KEGG hsa:3817; -.
Phylogenomic databases
HOGENOM P20151; -.
HOVERGEN P20151; -.
OMA P20151; AYSEKVT.
Other
NextBio 15005; -.
PMAP-CutDB P20151; -.
SOURCE KLK2; Homo sapiens.
ProtoNet P20151.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Disulfide bond; Glycoprotein; Hydrolase; Polymorphism; Protease; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Probable. 
PROPEP   19    24  6     Activation peptide (Probable). PRO_0000027929
CHAIN   25   261  237     Kallikrein-2. PRO_0000027930
DOMAIN   25   258  234     Peptidase S1. 
ACT_SITE   65    65        Charge relay system. 
ACT_SITE   120   120        Charge relay system. 
ACT_SITE   213   213        Charge relay system. 
CARBOHYD   102   102        N-linked (GlcNAc...) (Potential). 
DISULFID   31   173        By similarity. 
DISULFID   50    66        By similarity. 
DISULFID   152   219        By similarity. 
DISULFID   184   198        By similarity. 
DISULFID   209   234        By similarity. 
VAR_SEQ   165   261        Missing (in isoform 3). VSP_005400
VAR_SEQ   211   261        GDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYR KWIKDTIAANP -> VSHPYSQHLEGK (in isoform 2). VSP_005399
VARIANT   18    18  1     V -> L (in dbSNP:rs6072 [NCBI]). VAR_014164 
VARIANT   250   250  1     R -> W (in dbSNP:rs198977 [NCBI]). VAR_020178 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 28671 Da [This is the MW of the unprocessed precursor] CRC64: 9CF7F4A1162EF42D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWDLVLSIAL SVGCTGAVPL IQSRIVGGWE CEKHSQPWQV AVYSHGWAHC GGVLVHPQWV 

        70         80         90        100        110        120 
LTAAHCLKKN SQVWLGRHNL FEPEDTGQRV PVSHSFPHPL YNMSLLKHQS LRPDEDSSHD 

       130        140        150        160        170        180 
LMLLRLSEPA KITDVVKVLG LPTQEPALGT TCYASGWGSI EPEEFLRPRS LQCVSLHLLS 

       190        200        210        220        230        240 
NDMCARAYSE KVTEFMLCAG LWTGGKDTCG GDSGGPLVCN GVLQGITSWG PEPCALPEKP 

       250        260 
AVYTKVVHYR KWIKDTIAAN P 

P20151 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!