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UniProtKB/Swiss-Prot entry P19858

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_BOVIN
Primary accession number P19858
Secondary accession number A6H7E0
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 70)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
LDH muscle subunit
LDH-M
Gene name
Name: LDHA
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(90)90101-V; PubMed=2210387 [NCBI, ExPASy, EBI, Israel, Japan]
Ishiguro N., Osame S., Kagiya R., Ichijo S., Shinagawa M.;
"Primary structure of bovine lactate dehydrogenase-A isozyme and its synthesis in Escherichia coli.";
Gene 91:281-285(1990).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Fetal skin;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D90141; BAA14169.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D90142; BAA14170.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D90143; BAA14171.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC146210; AAI46211.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ2222; JQ2222.
RefSeq NP_776524.1; -.
UniGene Bt.3809
3D structure databases
HSSP P00339; 9LDT. [HSSP ENTRY / PDB]
SMR P19858; 2-332.
ModBase P19858.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from sequence or structural similarity from AgBase).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P19858.
Genome annotation databases
Ensembl ENSBTAG00000008683; Bos taurus. [Contig view]
GeneID 281274; -.
KEGG bta:281274; -.
Phylogenomic databases
HOVERGEN P19858; -.
Other
ProtoNet P19858.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168410
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   239   239        Phosphotyrosine (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36598 Da [This is the MW of the unprocessed precursor] CRC64: DAC59F02BBA7D16C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATLKDQLIQ NLLKEEHVPQ NKITIVGVGA VGMACAISIL MKDLADEVAL VDVMEDKLKG 

        70         80         90        100        110        120 
EMMDLQHGSL FLRTPKIVSG KDYNVTANSR LVIITAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNIVKYSPN CKLLVVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 

       190        200        210        220        230        240 
HPLSCHGWIL GEHGDSSVPV WSGVNVAGVS LKNLHPELGT DADKEQWKAV HKQVVDSAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGIKEDVFLS VPCILGQNGI 

       310        320        330 
SDVVKVTLTH EEEACLKKSA DTLWGIQKEL QF
P19858 in FASTA format

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