[1]
|
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 101-118 AND 309-325.
DOI=10.1016/0092-8674(90)90374-N; PubMed=1695551 [NCBI, ExPASy, EBI, Israel, Japan]
Meurs E.,
Chong K.,
Galabru J.,
Thomas N.S.B.,
Kerr I.M.,
Williams B.R.G.,
Hovanessian A.G.;
"Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.";
Cell 62:379-390(1990).
|
[2]
|
SEQUENCE REVISION.
Meurs E.;
Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases.
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0042-6822(92)90732-5; PubMed=1373553 [NCBI, ExPASy, EBI, Israel, Japan]
Thomis D.C.,
Doohan J.P.,
Samuel C.E.;
"Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells.";
Virology 188:33-46(1992).
|
[4]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1016/0378-1119(96)00314-9; PubMed=8921913 [NCBI, ExPASy, EBI, Israel, Japan]
Kuhen K.L.,
Shen X.,
Samuel C.E.;
"Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.";
Gene 178:191-193(1996).
|
[5]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
DOI=10.1006/geno.1996.0446; PubMed=8812437 [NCBI, ExPASy, EBI, Israel, Japan]
Kuhen K.L.,
Shen X.,
Carlisle E.R.,
Richardson A.L.,
Weier H.-U.G.,
Tanaka H.,
Samuel C.E.;
"Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog.";
Genomics 36:197-201(1996).
|
[6]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1089/jir.1998.18.609; PubMed=9726442 [NCBI, ExPASy, EBI, Israel, Japan]
Xu Z.,
Williams B.R.;
"Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region.";
J. Interferon Cytokine Res. 18:609-616(1998).
|
[7]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NIEHS SNPs program;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
|
[8]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Graves T.A.,
Fulton R.S.,
Fulton L.A.,
Pepin K.H.,
Minx P.,
Wagner-McPherson C.,
Layman D.,
Wylie K.,
Sekhon M.,
Becker M.C.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E.,
Kremitzki C.,
Oddy L.,
Du H.,
Sun H., ![]()
Bradshaw-Cordum H.,
Ali J.,
Carter J.,
Cordes M.,
Harris A.,
Isak A.,
van Brunt A.,
Nguyen C.,
Du F.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Abbott S.,
Armstrong J.,
Belter E.A.,
Caruso L.,
Cedroni M.,
Cotton M.,
Davidson T.,
Desai A.,
Elliott G.,
Erb T.,
Fronick C.,
Gaige T.,
Haakenson W.,
Haglund K.,
Holmes A.,
Harkins R.,
Kim K.,
Kruchowski S.S.,
Strong C.M.,
Grewal N.,
Goyea E.,
Hou S.,
Levy A.,
Martinka S.,
Mead K.,
McLellan M.D.,
Meyer R.,
Randall-Maher J.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Shah N.,
Swearengen-Shahid S.,
Snider J.,
Strong J.T.,
Thompson J.,
Yoakum M.,
Leonard S.,
Pearman C.,
Trani L.,
Radionenko M.,
Waligorski J.E.,
Wang C.,
Rock S.M.,
Tin-Wollam A.-M.,
Maupin R.,
Latreille P.,
Wendl M.C.,
Yang S.-P.,
Pohl C.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Berkowicz N.,
Nelson J.O.,
Osborne J.,
Ding L.,
Meyer R.,
Sabo A.,
Shotland Y.,
Sinha P.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Jones T.A.,
She X.,
Ciccarelli F.D.,
Izaurralde E.,
Taylor J.,
Schmutz J.,
Myers R.M.,
Cox D.R.,
Huang X.,
McPherson J.D.,
Mardis E.R.,
Clifton S.W.,
Warren W.C.,
Chinwalla A.T.,
Eddy S.R.,
Marra M.A.,
Ovcharenko I.,
Furey T.S.,
Miller W.,
Eichler E.E.,
Bork P.,
Suyama M.,
Torrents D.,
Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
|
[9]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[10]
|
INTERACTION WITH DNAJC3.
DOI=10.1074/jbc.271.3.1702; PubMed=8576172 [NCBI, ExPASy, EBI, Israel, Japan]
Polyak S.J.,
Tang N.,
Wambach M.,
Barber G.N.,
Katze M.G.;
"The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.";
J. Biol. Chem. 271:1702-1707(1996).
|
[11]
|
INTERACTION WITH HIV-1 TAT.
DOI=10.1074/jbc.272.13.8388; PubMed=9079663 [NCBI, ExPASy, EBI, Israel, Japan]
Brand S.R.,
Kobayashi R.,
Mathews M.B.;
"The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR.";
J. Biol. Chem. 272:8388-8395(1997).
|
[12]
|
INTERACTION WITH HCV NS5A.
DOI=10.1006/viro.1997.8493; PubMed=9143277 [NCBI, ExPASy, EBI, Israel, Japan]
Gale M.J. Jr.,
Korth M.J.,
Tang N.M.,
Tan S.-L.,
Hopkins D.A.,
Dever T.E.,
Polyak S.J.,
Gretch D.R.,
Katze M.G.;
"Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.";
Virology 230:217-227(1997).
|
[13]
|
INTERACTION WITH INFLUENZA A NS1 PROTEIN.
DOI=10.1089/jir.1998.18.757; PubMed=9781815 [NCBI, ExPASy, EBI, Israel, Japan]
Tan S.L.,
Katze M.G.;
"Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase.";
J. Interferon Cytokine Res. 18:757-766(1998).
|
[14]
|
INTERACTION WITH HCV E2 ENVELOPE PROTEIN.
DOI=10.1126/science.285.5424.107; PubMed=10390359 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor D.R.,
Shi S.T.,
Romano P.R.,
Barber G.N.,
Lai M.M.C.;
"Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.";
Science 285:107-110(1999).
|
[15]
|
PHOSPHORYLATION AT SER-83; THR-88; THR-89; THR-90; SER-242; THR-255 AND THR-258, MUTAGENESIS OF SER-83; THR-88; THR-89; THR-90; SER-242; THR-255; THR-258 AND LYS-296, AND INHIBITION BY HCV E2 ENVELOPE PROTEIN.
DOI=10.1128/JVI.75.3.1265-1273.2001; PubMed=11152499 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor D.R.,
Tian B.,
Romano P.R.,
Hinnebusch A.G.,
Lai M.M.C.,
Mathews M.B.;
"Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.";
J. Virol. 75:1265-1273(2001).
|
[16]
|
MUTAGENESIS, AND PHOSPHORYLATION AT THR-446 AND THR-451.
DOI=10.1074/jbc.M102108200; PubMed=11337501 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang F.,
Romano P.R.,
Nagamura-Inoue T.,
Tian B.,
Dever T.E.,
Mathews M.B.,
Ozato K.,
Hinnebusch A.G.;
"Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.";
J. Biol. Chem. 276:24946-24958(2001).
|
[17]
|
INHIBITION BY VACCINIA VIRUS PROTEIN E3.
DOI=10.1016/j.virol.2004.03.012; PubMed=15207627 [NCBI, ExPASy, EBI, Israel, Japan]
Langland J.O.,
Jacobs B.L.;
"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.";
Virology 324:419-429(2004).
|
[18]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-456, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
[19]
|
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
|
[20]
|
STRUCTURE BY NMR OF 1-175.
DOI=10.1093/emboj/17.18.5458; PubMed=9736623 [NCBI, ExPASy, EBI, Israel, Japan]
Nanduri S.,
Carpick B.W.,
Yang Y.,
Williams B.R.G.,
Qin J.;
"Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation.";
EMBO J. 17:5458-5465(1998).
|
[21]
|
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 258-550 IN COMPLEX WITH EIF2ALPHA, AND PHOSPHORYLATION AT THR-446.
DOI=10.1016/j.cell.2005.06.044; PubMed=16179258 [NCBI, ExPASy, EBI, Israel, Japan]
Dar A.C.,
Dever T.E.,
Sicheri F.;
"Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.";
Cell 122:887-900(2005).
|
[22]
|
VARIANTS [LARGE SCALE ANALYSIS] GLU-428; VAL-439 AND VAL-506.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
|
|
ExPASy Home page
SIB Switzerland
