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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=2166337 [NCBI, ExPASy, EBI, Israel, Japan]
Keinaenen K.,
Wisden W.,
Sommer B.,
Werner P.,
Herb A.,
Verdoorn T.A.,
Sakmann B.,
Seeburg P.H.;
"A family of AMPA-selective glutamate receptors.";
Science 249:556-560(1990).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Forebrain;
PubMed=2168579 [NCBI, ExPASy, EBI, Israel, Japan]
Boulter J.,
Hollmann M.,
O'Shea-Greenfield A.,
Hartley M.,
Deneris E.S.,
Maron C.,
Heinemann S.F.;
"Molecular cloning and functional expression of glutamate receptor subunit genes.";
Science 249:1033-1037(1990).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (VARIANT FLIP).
TISSUE=Brain cortex, and Hippocampus;
DOI=10.1016/0896-6273(90)90212-X; PubMed=1699567 [NCBI, ExPASy, EBI, Israel, Japan]
Nakanishi N.,
Schneider N.A.,
Axel R.;
"A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties.";
Neuron 5:569-581(1990).
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[4]
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ALTERNATIVE SPLICING (ISOFORMS FLIP AND FLOP).
TISSUE=Brain;
PubMed=1699275 [NCBI, ExPASy, EBI, Israel, Japan]
Sommer B.,
Keinaenen K.,
Verdoorn T.A.,
Wisden W.,
Burnashev N.,
Herb A.,
Koehler M.,
Takagi T.,
Sakmann B.,
Seeburg P.H.;
"Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.";
Science 249:1580-1585(1990).
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[5]
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INTERACTION WITH PRKCABP.
DOI=10.1016/S0896-6273(00)80689-3; PubMed=10027300 [NCBI, ExPASy, EBI, Israel, Japan]
Xia J.,
Zhang X.,
Staudinger J.,
Huganir R.L.;
"Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.";
Neuron 22:179-187(1999).
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[6]
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INTERACTION WITH GRIP1.
TISSUE=Hippocampus;
DOI=10.1038/386279a0; PubMed=9069286 [NCBI, ExPASy, EBI, Israel, Japan]
Dong H.,
O'Brien R.J.,
Fung E.T.,
Lanahan A.A.,
Worley P.F.,
Huganir R.L.;
"GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.";
Nature 386:279-284(1997).
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[7]
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INTERACTION WITH GRIP2.
PubMed=10414981 [NCBI, ExPASy, EBI, Israel, Japan]
Wyszynski M.,
Valtschanoff J.G.,
Naisbitt S.,
Dunah A.W.,
Kim E.,
Standaert D.G.,
Weinberg R.,
Sheng M.;
"Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo.";
J. Neurosci. 19:6528-6537(1999).
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- FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
- SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2.
- INTERACTION:
P18708:NSF (xeno); NbExp=1; IntAct=EBI-77764, EBI-925742;
Q9EP80:Pick1; NbExp=4; IntAct=EBI-77764, EBI-77728;
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
- PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-615 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-841 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
- MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 888 AA [This is the length of the unprocessed precursor] |
Molecular weight: 100373 Da [This is the MW of the unprocessed precursor] |
CRC64: 2981616375661703 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGQSVLRAVF FLVLGLLGHS HGGFPNTISI GGLFMRNTVQ EHSAFRFAVQ LYNTNQNTTE
70 80 90 100 110 120
KPFHLNYHVD HLDSSNSFSV TNAFCSQFSR GVYAIFGFYD QMSMNTLTSF CGALHTSFVT
130 140 150 160 170 180
PSFPTDADVQ FVIQMRPALK GAILSLLSYY KWEKFVYLYD TERGFSVLQA IMEAAVQNNW
190 200 210 220 230 240
QVTARSVGNI KDVQEFRRII EEMDRRQEKR YLIDCEVERI NTILEQVVIL GKHSRGYHYM
250 260 270 280 290 300
LANLGFTDIL LERVMHGGAN ITGFQIVNNE NPMVQQFIQR WVRLDEREFP EAKNAPLKYT
310 320 330 340 350 360
SALTHDAILV IAEAFRYLRR QRVDVSRRGS AGDCLANPAV PWSQGIDIER ALKMVQVQGM
370 380 390 400 410 420
TGNIQFDTYG RRTNYTIDVY EMKVSGSRKA GYWNEYERFV PFSDQQISND SSSSENRTIV
430 440 450 460 470 480
VTTILESPYV MYKKNHEQLE GNERYEGYCV DLAYEIAKHV RIKYKLSIVG DGKYGARDPE
490 500 510 520 530 540
TKIWNGMVGE LVYGRADIAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS
550 560 570 580 590 600
FLDPLAYEIW MCIVFAYIGV SVVLFLVSRF SPYEWHLEDN NEEPRDPQSP PDPPNEFGIF
610 620 630 640 650 660
NSLWFSLGAF MQQGCDISPR SLSGRIVGGV WWFFTLIIIS SYTANLAAFL TVERMVSPIE
670 680 690 700 710 720
SAEDLAKQTE IAYGTLDSGS TKEFFRRSKI AVYEKMWSYM KSAEPSVFTK TTADGVARVR
730 740 750 760 770 780
KSKGKFAFLL ESTMNEYIEQ RKPCDTMKVG GNLDSKGYGV ATPKGSALGN AVNLAVLKLN
790 800 810 820 830 840
EQGLLDKLKN KWWYDKGECG SGGGDSKDKT SALSLSNVAG VFYILVGGLG LAMMVALIEF
850 860 870 880
CYKSRAESKR MKLTKNTQNF KPAPATNTQN YATYREGYNV YGTESVKI
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P19492 in FASTA format |
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ExPASy Home page
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