[1]	NUCLEOTIDE SEQUENCE. DOI=10.1016/0014-5793(89)80563-0; PubMed=2465923 [NCBI, ExPASy, EBI, Israel, Japan] Schofield P.R., Pritchett D.B., Sontheimer H., Kettenmann H., Seeburg P.H.; "Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits."; FEBS Lett. 244:361-364(1989).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0888-7543(91)90189-L; PubMed=1655634 [NCBI, ExPASy, EBI, Israel, Japan] Kirkness E.F., Kusiak J.W., Fleming J.T., Menninger J., Gocayne J.D., Ward D.C., Venter J.C.; "Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1)."; Genomics 10:985-995(1991).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-429. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE OF 19-474. PubMed=2160058 [NCBI, ExPASy, EBI, Israel, Japan] Garrett K.M., Saito N., Duman R.S., Abel M.S., Ashton R.A., Fujimori S., Beer B., Tallman J.F., Vitek M.P., Blume A.J.; "Differential expression of gamma-aminobutyric acidA receptor subunits."; Mol. Pharmacol. 37:652-657(1990).
[5]	NUCLEOTIDE SEQUENCE [MRNA] OF 404-434, AND VARIANT GLN-421. PubMed=8178835 [NCBI, ExPASy, EBI, Israel, Japan] Coon H., Sobell J., Heston L., Sommer S., Hoff M., Holik J., Umar F., Robertson M., Reimherr F., Wender P.; "Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia."; Am. J. Med. Genet. 54:12-20(1994).
[6]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, AND MASS SPECTROMETRY. TISSUE=Epithelium; DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan] Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; J. Proteome Res. 6:4150-4162(2007).

Comments

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt056.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X14767; CAA32875.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M59216; AAA35862.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M59212; AAA35862.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M59214; AAA35862.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M59215; AAA35862.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022449; AAH22449.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S70733; AAB30712.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A40336; A40336.

NP_000803.2; -.

3D structure databases

ModBase

P18505.

PTM databases

PhosphoSite

P18505; -.

Organism-specific databases

HGNC:4081; GABRB1.

137190; gene. [NCBI / EBI]

PharmGKB

PA28495; -.

GeneCards

P18505.

Gene expression databases

ArrayExpress

P18505; -.

CleanEx

HS_GABRB1; -.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004890;	Molecular function: GABA-A receptor activity (traceable author statement from ProtInc).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
GO:0006810;	Biological process: transport (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR006028; GABAA_rcpt.
IPR002289; GABAAb_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.

Gene3D

G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.

PANTHER

PTHR18945; Neur_channel; 1.

Pfam

PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.

PRINTS

PR01160; GABAARBETA.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.

TIGRFAMs

TIGR00860; LIC; 1.

PROSITE

PS00236; NEUROTR_ION_CHANNEL; 1.

BLOCKS

P18505.

Genome annotation databases

Ensembl

ENSG00000163288; Homo sapiens. [Contig view]

GeneID

2560; -.

KEGG

hsa:2560; -.

Phylogenomic databases

HOGENOM

P18505; -.

HOVERGEN

P18505; -.

Other

DrugBank

DB00189; Ethchlorvynol.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00683; Midazolam.

SOURCE

GABRB1; Homo sapiens.

ProtoNet

P18505.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 25`	`25`	`Potential.`
`CHAIN`	`26 474`	`449`	`Gamma-aminobutyric acid receptor subunit beta-1.`	`PRO_0000000456`
`TOPO_DOM`	`26 245`	`220`	`Extracellular (Probable).`
`TRANSMEM`	`246 267`	`22`	`Probable.`
`TRANSMEM`	`271 293`	`23`	`Probable.`
`TRANSMEM`	`305 327`	`23`	`Probable.`
`TOPO_DOM`	`328 451`	`124`	`Cytoplasmic (Probable).`
`TRANSMEM`	`452 473`	`22`	`Probable.`
`MOD_RES`	`448 448`		`Phosphoserine.`
`CARBOHYD`	`105 105`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`174 174`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`161 175`		`By similarity.`
`VARIANT`	`421 421`	`1`	`H -> Q (found in 1.1% of population and in some schizophrenic patients; dbSNP:rs41311286 [NCBI]).`	`VAR_000302`
`VARIANT`	`429 429`	`1`	`I -> N (in dbSNP:rs17852014 [NCBI]).`	`VAR_035441`
`CONFLICT`	`35 35`		`S -> P (in Ref. 1; CAA32875).`
`CONFLICT`	`117 117`		`W -> C (in Ref. 3; AAH22449).`

Sequence information

Length: 474 AA [This is the length of the unprocessed precursor]

Molecular weight: 54235 Da [This is the MW of the unprocessed precursor]

CRC64: 05DA70F6FCD04E54 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWTVQNRESL GLLSFPVMIT MVCCAHSTNE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP 

        70         80         90        100        110        120 
VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD 

       130        140        150        160        170        180 
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 

       190        200        210        220        230        240 
SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK 

       250        260        270        280        290        300 
RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 

       310        320        330        340        350        360 
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE KNKLEMNKVQ 

       370        380        390        400        410        420 
VDAHGNILLS TLEIRNETSG SEVLTSVSDP KATMYSYDSA SIQYRKPLSS REAYGRALDR 

       430        440        450        460        470 
HGVPSKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH

P18505 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools