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UniProtKB/Swiss-Prot entry P17927


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CR1_HUMAN
Primary accession number P17927
Secondary accession numbers Q16745 Q5SR45 Q9UQV2
Integrated into Swiss-Prot on November 1, 1990
Sequence was last modified on November 25, 2008 (Sequence version 2)
Annotations were last modified on    May 26, 2009 (Entry version 107)
Name and origin of the protein
Protein name Complement receptor type 1 [Precursor]
Synonyms C3b/C4b receptor
CD35 antigen
Gene name
Name: CR1
Synonyms: C3BR
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1084/jem.168.5.1699; PubMed=2972794 [NCBI, ExPASy, EBI, Israel, Japan]
Klickstein L.B., Bartow T.J., Miletic V., Rabson L.D., Smith J.A., Fearon D.T.;
"Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.";
J. Exp. Med. 168:1699-1717(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-1615; ARG-1827; ASP-1850 AND ALA-1969.
PubMed=8245463 [NCBI, ExPASy, EBI, Israel, Japan]
Vik D.P., Wong W.W.;
"Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele.";
J. Immunol. 151:6214-6224(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-1610.
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE OF 1-41.
DOI=10.1084/jem.169.3.847; PubMed=2564414 [NCBI, ExPASy, EBI, Israel, Japan]
Wong W.W., Cahill J.M., Rosen M.D., Kennedy C.A., Bonaccio E.T., Morris M.J., Wilson J.G., Klickstein L.B., Fearon D.T.;
"Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.";
J. Exp. Med. 169:847-863(1989).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 26-584.
DOI=10.1084/jem.168.4.1255; PubMed=2971757 [NCBI, ExPASy, EBI, Israel, Japan]
Hourcade D., Miesner D.R., Atkinson J.P., Holers V.M.;
"Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1.";
J. Exp. Med. 168:1255-1270(1988).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 503-2039, AND VARIANT ALA-1969.
DOI=10.1084/jem.165.4.1095; PubMed=2951479 [NCBI, ExPASy, EBI, Israel, Japan]
Klickstein L.B., Wong W.W., Smith J.A., Weis J.H., Wilson J.G., Fearon D.T.;
"Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.";
J. Exp. Med. 165:1095-1112(1987).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 761-783; 831-845 AND 1179-1195.
DOI=10.1073/pnas.82.22.7711; PubMed=2933745 [NCBI, ExPASy, EBI, Israel, Japan]
Wong W.W., Klickstein L.B., Smith J.A., Weis J.H., Fearon D.T.;
"Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.";
Proc. Natl. Acad. Sci. U.S.A. 82:7711-7715(1985).
[8]
VARIANTS ARG-1208; GLU-1590; GLY-1601; THR-1610; VAL-1615; ARG-1827 AND ASP-1850.
DOI=10.1182/blood.V97.9.2879; PubMed=11313284 [NCBI, ExPASy, EBI, Israel, Japan]
Moulds J.M., Zimmerman P.A., Doumbo O.K., Kassambara L., Sagara I., Diallo D.A., Atkinson J.P., Krych-Goldberg M., Hauhart R.E., Hourcade D.E., McNamara D.T., Birmingham D.J., Rowe J.A., Moulds J.J., Miller L.H.;
"Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.";
Blood 97:2879-2885(2001).
[9]
VARIANTS SL(2)/VIL GLY-1601 AND SL(3) THR-1610.
DOI=10.1046/j.1537-2995.2002.00002.x; PubMed=11896343 [NCBI, ExPASy, EBI, Israel, Japan]
Moulds J.M., Zimmerman P.A., Doumbo O.K., Diallo D.A., Atkinson J.P., Krych-Goldberg M., Hourcade D.E., Moulds J.J.;
"Expansion of the Knops blood group system and subdivision of Sl(a).";
Transfusion 42:251-256(2002).
[10]
STRUCTURE BY NMR OF 942-1133.
DOI=10.1016/S0092-8674(02)00672-4; PubMed=11955431 [NCBI, ExPASy, EBI, Israel, Japan]
Smith B.O., Mallin R.L., Krych-Goldberg M., Wang X., Hauhart R.E., Bromek K., Uhrin D., Atkinson J.P., Barlow P.N.;
"Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.";
Cell 108:769-780(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00816; CAA68755.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17418; AAB60694.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17390; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17399; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17409; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17419; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17420; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17421; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17422; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17423; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17391; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17392; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17393; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17394; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17395; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17396; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17397; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17398; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17400; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17401; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17402; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17403; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17404; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17405; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17406; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17407; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17408; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17410; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17411; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17412; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17413; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17414; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17415; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17416; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L17417; AAB60694.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137789; CAI16042.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL691452; CAI16042.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL691452; CAI16723.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137789; CAI16723.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X14362; CAA32541.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05309; CAA28933.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11569; AAA52297.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11617; AAA52298.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M11618; AAA52299.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00412546; -.
PIR I73012; I73012.
RefSeq NP_000564.2; -.
NP_000642.3; -.
UniGene Hs.334019
3D structure databases
PDB
1GKG; NMR; -; A=1002-1133.[ExPASy / RCSB / EBI]
1GKN; NMR; -; A=942-1065.[ExPASy / RCSB / EBI]
1GOP; Model; -; A=942-1133.[ExPASy / RCSB / EBI]
1PPQ; NMR; -; A=1002-1065.[ExPASy / RCSB / EBI]
2Q7Z; X-ray; -; A=42-1972.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1GKG; -.
1GKN; -.
1GOP; -.
1PPQ; -.
2Q7Z; -.
SMR P17927; 102-233, 491-615, 552-683.
ModBase P17927.
PTM databases
PhosphoSite P17927; -.
Organism-specific databases
GeneCards GC01P205736; -.
H-InvDB HIX0028732; -.
HGNC HGNC:2334; CR1.
GenAtlas CR1.
HPA CAB016271; -.
MIM 120620; gene. [NCBI / EBI]
607486; phenotype. [NCBI / EBI]
Orphanet 536; Lupus erythematosus, systemic.
PharmGKB PA24772; -.
Gene expression databases
ArrayExpress P17927; -.
Bgee P17927; -.
CleanEx HS_CR1; -.
GermOnline ENSG00000203710; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004875; Molecular function: complement receptor activity (traceable author statement from ProtInc).
GO:0006958; Biological process: complement activation, classical pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0045087; Biological process: innate immune response (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.
Pfam PF00084; Sushi; 30.
Pfam graphical view of domain structure.
PROSITE PS50923; SUSHI; 30.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000203710; Homo sapiens. [Contig view]
GeneID 1378; -.
KEGG hsa:1378; -.
Phylogenomic databases
HOVERGEN P17927; -.
Other
NextBio 5589; -.
SOURCE CR1; Homo sapiens.
ProtoNet P17927.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Blood group antigen; Complement pathway; Disulfide bond; Glycoprotein; Immune response; Innate immunity; Membrane; Polymorphism; Pyrrolidone carboxylic acid; Receptor; Repeat; Signal; Sushi; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     41  41      
CHAIN   42   2039  1998     Complement receptor type 1. PRO_0000006009
TOPO_DOM   42   1971  1930     Extracellular (Potential). 
TRANSMEM   1972   1996  25     Potential. 
TOPO_DOM   1997   2039  43     Cytoplasmic (Potential). 
DOMAIN   42    101  60     Sushi 1. 
DOMAIN   102    163  62     Sushi 2. 
DOMAIN   164    234  71     Sushi 3. 
DOMAIN   236    295  60     Sushi 4. 
DOMAIN   295    355  61     Sushi 5. 
DOMAIN   356    418  63     Sushi 6. 
DOMAIN   419    489  71     Sushi 7. 
DOMAIN   491    551  61     Sushi 8. 
DOMAIN   552    613  62     Sushi 9. 
DOMAIN   614    684  71     Sushi 10. 
DOMAIN   686    745  60     Sushi 11. 
DOMAIN   745    805  61     Sushi 12. 
DOMAIN   806    868  63     Sushi 13. 
DOMAIN   869    939  71     Sushi 14. 
DOMAIN   941   1001  61     Sushi 15. 
DOMAIN   1002   1063  62     Sushi 16. 
DOMAIN   1064   1134  71     Sushi 17. 
DOMAIN   1136   1195  60     Sushi 18. 
DOMAIN   1195   1255  61     Sushi 19. 
DOMAIN   1256   1318  63     Sushi 20. 
DOMAIN   1319   1389  71     Sushi 21. 
DOMAIN   1394   1454  61     Sushi 22. 
DOMAIN   1455   1516  62     Sushi 23. 
DOMAIN   1517   1587  71     Sushi 24. 
DOMAIN   1589   1648  60     Sushi 25. 
DOMAIN   1648   1708  61     Sushi 26. 
DOMAIN   1709   1771  63     Sushi 27. 
DOMAIN   1772   1842  71     Sushi 28. 
DOMAIN   1846   1906  61     Sushi 29. 
DOMAIN   1907   1967  61     Sushi 30. 
MOD_RES   42     42        Pyrrolidone carboxylic acid (Potential). 
CARBOHYD   56     56        N-linked (GlcNAc...) (Potential). 
CARBOHYD   252    252        N-linked (GlcNAc...) (Potential). 
CARBOHYD   410    410        N-linked (GlcNAc...) (Potential). 
CARBOHYD   447    447        N-linked (GlcNAc...) (Potential). 
CARBOHYD   509    509        N-linked (GlcNAc...) (Potential). 
CARBOHYD   578    578        N-linked (GlcNAc...) (Potential). 
CARBOHYD   702    702        N-linked (GlcNAc...) (Potential). 
CARBOHYD   860    860        N-linked (GlcNAc...) (Potential). 
CARBOHYD   897    897        N-linked (GlcNAc...) (Potential). 
CARBOHYD   959    959        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1028   1028        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1152   1152        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1310   1310        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1481   1481        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1504   1504        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1534   1534        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1540   1540        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1605   1605        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1763   1763        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1908   1908        N-linked (GlcNAc...) (Potential). 
DISULFID   43     86        By similarity. 
DISULFID   73     99        By similarity. 
DISULFID   104    145        By similarity. 
DISULFID   131    161        By similarity. 
DISULFID   166    215        By similarity. 
DISULFID   195    232        By similarity. 
DISULFID   238    280        By similarity. 
DISULFID   266    293        By similarity. 
DISULFID   297    340        By similarity. 
DISULFID   326    353        By similarity. 
DISULFID   358    400        By similarity. 
DISULFID   386    416        By similarity. 
DISULFID   421    470        By similarity. 
DISULFID   450    487        By similarity. 
DISULFID   493    536        By similarity. 
DISULFID   523    549        By similarity. 
DISULFID   554    595        By similarity. 
DISULFID   581    611        By similarity. 
DISULFID   616    665        By similarity. 
DISULFID   645    682        By similarity. 
DISULFID   688    730        By similarity. 
DISULFID   716    743        By similarity. 
DISULFID   747    790        By similarity. 
DISULFID   776    803        By similarity. 
DISULFID   808    850        By similarity. 
DISULFID   836    866        By similarity. 
DISULFID   871    920        By similarity. 
DISULFID   900    937        By similarity. 
DISULFID   943    986        By similarity. 
DISULFID   973    999        By similarity. 
DISULFID   1004   1045         
DISULFID   1031   1061         
DISULFID   1066   1115         
DISULFID   1095   1132         
DISULFID   1138   1180        By similarity. 
DISULFID   1166   1193        By similarity. 
DISULFID   1197   1240        By similarity. 
DISULFID   1226   1253        By similarity. 
DISULFID   1258   1300        By similarity. 
DISULFID   1286   1316        By similarity. 
DISULFID   1321   1370        By similarity. 
DISULFID   1350   1387        By similarity. 
DISULFID   1396   1439        By similarity. 
DISULFID   1426   1452        By similarity. 
DISULFID   1457   1498        By similarity. 
DISULFID   1484   1514        By similarity. 
DISULFID   1519   1568        By similarity. 
DISULFID   1548   1585        By similarity. 
DISULFID   1591   1633        By similarity. 
DISULFID   1619   1646        By similarity. 
DISULFID   1650   1693        By similarity. 
DISULFID   1679   1706        By similarity. 
DISULFID   1711   1753        By similarity. 
DISULFID   1739   1769        By similarity. 
DISULFID   1774   1823        By similarity. 
DISULFID   1803   1840        By similarity. 
DISULFID   1848   1891        By similarity. 
DISULFID   1877   1904        By similarity. 
DISULFID   1909   1952        By similarity. 
DISULFID   1938   1965        By similarity. 
VARIANT   1208   1208  1     H -> R (in dbSNP:rs2274567 [NCBI]). VAR_013819 
VARIANT   1408   1408  1     T -> I. VAR_013820 
VARIANT   1408   1408  1     T -> M (in dbSNP:rs3737002 [NCBI]). VAR_020263 
VARIANT   1540   1540  1     N -> S (in dbSNP:rs17259045 [NCBI]). VAR_055685 
VARIANT   1590   1590  1     K -> E (in MCC(b) antigen; dbSNP:rs17047660 [NCBI]). VAR_013821 
VARIANT   1601   1601  1     R -> G (in Sl(2)/Vil antigen and Sl(3) antigen; dbSNP:rs17047661 [NCBI]). VAR_013822 
VARIANT   1610   1610  1     S -> T (in Sl(3) antigen). VAR_013823 
VARIANT   1615   1615  1     I -> V (in dbSNP:rs6691117 [NCBI]). VAR_013824 
VARIANT   1827   1827  1     P -> R (in dbSNP:rs3811381 [NCBI]). VAR_013825 
VARIANT   1850   1850  1     H -> D. VAR_013826 
VARIANT   1969   1969  1     T -> A (in dbSNP:rs2296160 [NCBI]). VAR_055686 
CONFLICT   173    173        A -> T (in Ref. 1; CAA68755, 2; AAB60694 and 5; CAA32541). 
CONFLICT   445    445        T -> A (in Ref. 1; CAA68755, 2; AAB60694 and 5; CAA32541). 
CONFLICT   1876   1876        I -> T (in Ref. 1; CAA68755 and 6; CAA28933). 
STRAND   950    954  5      
STRAND   961    966  6      
STRAND   968    973  6      
STRAND   977    979  3      
STRAND   982    986  5      
STRAND   988    990  3      
STRAND   1014   1016  3      
STRAND   1026   1030  5      
STRAND   1033   1037  5      
STRAND   1041   1047  7      
STRAND   1049   1056  8      
STRAND   1061   1063  3      
STRAND   1090   1093  4      
STRAND   1107   1109  3      
STRAND   1112   1114  3      
STRAND   1118   1122  5      
Sequence information
Length: 2039 AA [This is the length of the unprocessed precursor] Molecular weight: 223633 Da [This is the MW of the unprocessed precursor] CRC64: 1079E1F351E4BFD2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 

        70         80         90        100        110        120 
FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 

       130        140        150        160        170        180 
IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TIANGDFIST 

       190        200        210        220        230        240 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 

       250        260        270        280        290        300 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 

       310        320        330        340        350        360 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 

       370        380        390        400        410        420 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 

       430        440        450        460        470        480 
CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 

       490        500        510        520        530        540 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 

       550        560        570        580        590        600 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 

       610        620        630        640        650        660 
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 

       670        680        690        700        710        720 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 

       730        740        750        760        770        780 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 

       790        800        810        820        830        840 
DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 

       850        860        870        880        890        900 
QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC 

       910        920        930        940        950        960 
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 

       970        980        990       1000       1010       1020 
SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 

      1030       1040       1050       1060       1070       1080 
IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST 

      1090       1100       1110       1120       1130       1140 
NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 

      1150       1160       1170       1180       1190       1200 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 

      1210       1220       1230       1240       1250       1260 
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD 

      1270       1280       1290       1300       1310       1320 
FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF 

      1330       1340       1350       1360       1370       1380 
CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW 

      1390       1400       1410       1420       1430       1440 
SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL 

      1450       1460       1470       1480       1490       1500 
ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV 

      1510       1520       1530       1540       1550       1560 
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL 

      1570       1580       1590       1600       1610       1620 
VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFS LTEIIRFRCQ 

      1630       1640       1650       1660       1670       1680 
PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE 

      1690       1700       1710       1720       1730       1740 
PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD 

      1750       1760       1770       1780       1790       1800 
EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS 

      1810       1820       1830       1840       1850       1860 
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI 

      1870       1880       1890       1900       1910       1920 
GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK 

      1930       1940       1950       1960       1970       1980 
ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG 

      1990       2000       2010       2020       2030 
TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP 

P17927 in FASTA format

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