ID   4CL1_ORYSJ              Reviewed;         564 AA.
AC   P17814; Q6ZKV9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   01-JUL-2008, entry version 56.
DE   4-coumarate--CoA ligase 1 (EC 6.2.1.12) (4CL 1) (4-coumaroyl-CoA
DE   synthase 1).
GN   Name=4CL1; Synonyms=4CL;
GN   OrderedLocusNames=Os08g0245200, LOC_Os08g14760;
GN   ORFNames=OJ1033_B09.16;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91045096; PubMed=2235510; DOI=10.1093/nar/18.20.6144;
RA   Zhao Y., Kung S.D., Dube S.K.;
RT   "Nucleotide sequence of rice 4-coumarate:CoA ligase gene, 4-CL.1.";
RL   Nucleic Acids Res. 18:6144-6144(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RG   The international rice genome sequencing project (IRGSP) consortium;
RT   "Oryza sativa nipponbare chromosome 8 genomic DNA sequence.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-coumarate + CoA = AMP + diphosphate +
CC       4-coumaroyl-CoA.
CC   -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC       biosynthesis; 3,4',5-trihydroxystilbene from 4-coumaric acid: step
CC       1/2.
CC   -!- INDUCTION: By fungal elicitor and UV irradiation.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA36850.1; Type=Erroneous gene model prediction;
CC       Sequence=CAA36850.1; Type=Frameshift; Positions=496;
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DR   EMBL; X52623; CAA36850.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP003859; BAD05189.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AK069932; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; JU0311; JU0311.
DR   RefSeq; NP_001061353.1; -.
DR   UniGene; Os.52921; -.
DR   HSSP; P08659; 1LCI.
DR   GeneID; 4345054; -.
DR   KEGG; osa:4345054; -.
DR   Gramene; P17814; -.
DR   GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:EC.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PRINTS; PR00154; AMPBINDING.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Ligase; Phenylpropanoid metabolism.
FT   CHAIN         1    564       4-coumarate--CoA ligase 1.
FT                                /FTId=PRO_0000193031.
FT   CONFLICT    405    405       P -> R (in Ref. 1; CAA36850).
FT   CONFLICT    477    477       I -> N (in Ref. 1; CAA36850).
SQ   SEQUENCE   564 AA;  60902 MW;  9725A4B4A72F8C6E CRC64;
     MGSMEQQQPE SAAPATEASP EIIFRSKLQD IAITNTLPLH RYCFERLPEV AARPCLIDGA
     TGGVLTYADV DRLSRRLAAA LRRAPLGLRR GGVVMSLLRN SPEFVLSFFA ASRVGAAVTT
     ANPMSTPHEI ESQLAAAGAT VVITESMAAD KLPSHSHGAL TVVLIDERRD GCLHFWDDLM
     SEDEASPLAG DEDDEKVFDP DDVVALPYSS GTTGLPKGVM LTHRSLSTSV AQQVDGENPN
     IGLHAGDVIL CALPMFHIYS LNTIMMCGLR VGAAIVVMRR FDLAAMMDLV ERHRVTIAPL
     VPPIVVAVAK SEAAAARDLS SVRMVLSGAA PMGKDIEDAF MAKLPGAVLG QGYGMTEAGP
     VLSMCLAFAK EPFKVKSGAC GTVVRNAELK IIDPDTGKSL GRNLPGEICI RGQQIMKGYL
     NNPEATKNTI DAEGWLHTGD IGYVDDDDEI FIVDRLKEII KYRGFQVAPA ELEALLITHP
     SIADAAVVGK QIEPEIGEIP VAFVAKTEGS ELSEDDVKQF VAKEVIYYKK IREVFFVDKI
     PKAPSGKILR KELRKQLQHL QQEA
//