[1]
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PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=2180939 [NCBI, ExPASy, EBI, Israel, Japan]
Haack J.A.,
Rivier J.E.,
Parks T.N.,
Mena E.E.,
Cruz L.J.,
Olivera B.M.;
"Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activity.";
J. Biol. Chem. 265:6025-6029(1990).
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[2]
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FUNCTION.
PubMed=2165278 [NCBI, ExPASy, EBI, Israel, Japan]
Olivera B.M.,
Rivier J.,
Clark C.,
Ramilo C.A.,
Corpuz G.P.,
Abogadie F.C.,
Mena E.E.,
Woodward S.R.,
Hillyard D.R.,
Cruz L.J.;
"Diversity of Conus neuropeptides.";
Science 249:257-263(1990).
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[3]
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MUTAGENESIS OF TYR-5.
DOI=10.1074/jbc.M102428200; PubMed=11335724 [NCBI, ExPASy, EBI, Israel, Japan]
Klein R.C.,
Prorok M.,
Galdzicki Z.,
Castellino F.J.;
"The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors.";
J. Biol. Chem. 276:26860-26867(2001).
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[4]
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THERAPEUTIC USAGE.
DOI=10.1016/S0304-3959(02)00303-2; PubMed=12507705 [NCBI, ExPASy, EBI, Israel, Japan]
Malmberg A.B.,
Gilbert H.,
McCabe R.T.,
Basbaum A.I.;
"Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T.";
Pain 101:109-116(2003).
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[5]
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STRUCTURE BY NMR.
DOI=10.1016/S0014-5793(97)00573-5; PubMed=9247135 [NCBI, ExPASy, EBI, Israel, Japan]
Warder S.E.,
Chen Z.,
Zhu Y.,
Prorok M.,
Castellino F.J.,
Ni F.;
"The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions.";
FEBS Lett. 411:19-26(1997).
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[6]
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STRUCTURE BY NMR.
DOI=10.1074/jbc.272.4.2291; PubMed=8999936 [NCBI, ExPASy, EBI, Israel, Japan]
Skjaerbaek N.,
Nielsen K.J.,
Lewis R.J.,
Alewood P.F.,
Craik D.J.;
"Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy.";
J. Biol. Chem. 272:2291-2299(1997).
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