[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0896-6273(88)90196-1; PubMed=3272162 [NCBI, ExPASy, EBI, Israel, Japan] Kosik K.S., Orecchio L.D., Bruns G.A.P., Benowitz L.I., McDonald G.P., Cox D.R., Neve R.; "Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human."; Neuron 1:127-132(1988).
[2]	NUCLEOTIDE SEQUENCE. DOI=10.1016/0896-6273(88)90197-3; PubMed=3272163 [NCBI, ExPASy, EBI, Israel, Japan] Ng S.-C., de la Monte S.M., Conboy G.L., Karns L.R., Fishman M.C.; "Cloning of human GAP-43: growth association and ischemic resurgence."; Neuron 1:133-139(1988).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0169-328X(93)90128-C; PubMed=8231732 [NCBI, ExPASy, EBI, Israel, Japan] Nielander H.B., de Groen P.C., Eggen B.J., Schrama L.H., Gispen W.H., Schotman P.; "Structure of the human gene for the neural phosphoprotein B-50 (GAP-43)."; Brain Res. Mol. Brain Res. 19:293-302(1993).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. NIEHS SNPs program; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[6]	VARIANT ILE-59. DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan] Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.; "Characterization of single-nucleotide polymorphisms in coding regions of human genes."; Nat. Genet. 22:231-238(1999).
[7]	ERRATUM. Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.; Nat. Genet. 23:373-373(1999).

Comments

FUNCTION: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.
SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
INTERACTION:
Q05655:PRKCD; NbExp=3; IntAct=EBI-1267511, EBI-704279;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
PTM: Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
SIMILARITY: Belongs to the neuromodulin family.
SIMILARITY: Contains 1 IQ domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gap43/";.
WEB RESOURCE: Name=Wikipedia; Note=Gap-43 entry; URL="http://en.wikipedia.org/wiki/Gap-43_protein";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M25667; AAA52516.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S66541; AAB28649.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S66533; AAB28649.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S66534; AAB28649.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY842481; AAV88094.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007936; AAH07936.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00015964; -.

I52638; I52638.

NP_002036.1; -.

3D structure databases

ModBase

P17677.

Protein-protein interaction databases

DIP

DIP:452N; -.

IntAct

P17677; 1.

PTM databases

PhosphoSite

P17677; -.

Organism-specific databases

GC03P116825; -.

HIX0003572; -.

HGNC:4140; GAP43.

CAB004417; -.
HPA013392; -.
HPA015600; -.

MIM

162060; gene. [NCBI / EBI]

PharmGKB

PA28553; -.

Gene expression databases

P17677; -.

P17677; -.

HS_GAP43; -.

ENSG00000172020; Homo sapiens.

Ontologies

GO:0030054;	Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0032584;	Cellular component: growth cone membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0045202;	Cellular component: synapse (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005516;	Molecular function: calmodulin binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007205;	Biological process: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway (traceable author statement from ProtInc).
GO:0040008;	Biological process: regulation of growth (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000048; IQ_CaM_bd_region.
IPR001422; Neuromodulin.
IPR017454; Neuromodulin_C.
IPR018947; Neuromodulin_gap-junction_N.
IPR018243; Neuromodulin_palmitoyl/P.
Graphical view of domain structure.

Pfam

PF00612; IQ; 1.
PF06614; Neuromodulin; 1.
PF10580; Neuromodulin_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00215; NEUROMODULIN.

SMART

SM00015; IQ; 1.
SMART graphical view of domain structure.

PROSITE

PS50096; IQ; 1.
PS00412; NEUROMODULIN_1; 1.
PS00413; NEUROMODULIN_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P17677; -.

Genome annotation databases

Ensembl

ENSG00000172020; Homo sapiens. [Contig view]

GeneID

2596; -.

Phylogenomic databases

HOGENOM

P17677; -.

HOVERGEN

P17677; -.

Other

10267; -.

GAP43; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calmodulin-binding; Cell junction; Cell membrane; Cell projection; Developmental protein; Differentiation; Growth regulation; Lipoprotein; Membrane; Neurogenesis; Palmitate; Phosphoprotein; Polymorphism; Synapse.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 238`	`238`	`Neuromodulin.`	`PRO_0000159596`
`DOMAIN`	`31 60`	`30`	`IQ.`
`REGION`	`1 4`	`4`	`Important for membrane binding.`
`MOD_RES`	`41 41`		`Phosphoserine (By similarity).`
`MOD_RES`	`94 94`		`Phosphothreonine (By similarity).`
`MOD_RES`	`181 181`		`Phosphothreonine (By similarity).`
`MOD_RES`	`202 202`		`Phosphoserine; by CK2 (By similarity).`
`MOD_RES`	`203 203`		`Phosphoserine; by CK2 (By similarity).`
`LIPID`	`3 3`		`S-palmitoyl cysteine (By similarity).`
`LIPID`	`4 4`		`S-palmitoyl cysteine (By similarity).`
`VARIANT`	`59 59`	`1`	`V -> I (in dbSNP:rs6291 [NCBI]).`	`VAR_014172`
`VARIANT`	`162 162`	`1`	`K -> E (in dbSNP:rs11557762 [NCBI]).`	`VAR_050271`

Sequence information

Length: 238 AA [This is the length of the unprocessed precursor]

Molecular weight: 24803 Da [This is the MW of the unprocessed precursor]

CRC64: B3536D012A127CC8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ 

        70         80         90        100        110        120 
AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT 

       130        140        150        160        170        180 
EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT 

       190        200        210        220        230 
TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA

P17677 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools