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UniProtKB/Swiss-Prot entry P17596


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRDB_WOLSU
Primary accession number P17596
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on August 1, 1990 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 88)
Name and origin of the protein
Protein name Fumarate reductase iron-sulfur subunit
Synonym EC 1.3.99.1
Gene name
Name: frdB
OrderedLocusNames: WS0830
From
Wolinella succinogenes [TaxID: 844] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Wolinella.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/BF00276536; PubMed=2244791 [NCBI, ExPASy, EBI, Israel, Japan]
Lauterbach F., Koertner C., Albracht S.P., Unden G., Kroeger A.;
"The fumarate reductase operon of Wolinella succinogenes. Sequence and expression of the frdA and frdB genes.";
Arch. Microbiol. 154:386-393(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=9492313 [NCBI, ExPASy, EBI, Israel, Japan]
Simon J., Gross R., Ringel M., Schmidt E., Kroeger A.;
"Deletion and site-directed mutagenesis of the Wolinella succinogenes fumarate reductase operon.";
Eur. J. Biochem. 251:418-426(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSMZ 1740;
DOI=10.1073/pnas.1932838100; PubMed=14500908 [NCBI, ExPASy, EBI, Israel, Japan]
Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O., Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B., Meyer F., Lederer H., Schuster S.C.;
"Complete genome sequence and analysis of Wolinella succinogenes.";
Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003).
[4]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
DOI=10.1038/46483; PubMed=10586875 [NCBI, ExPASy, EBI, Israel, Japan]
Lancaster C.R.D., Kroeger A., Auer M., Michel H.;
"Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution.";
Nature 402:377-385(1999).
[5]
X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS).
PubMed=11248702 [NCBI, ExPASy, EBI, Israel, Japan]
Lancaster C.R.D., Gross R., Simon J.;
"A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction.";
Eur. J. Biochem. 268:1820-1827(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ000662; CAA04215.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX571659; CAE09941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C44954; C44954.
RefSeq NP_907041.1; -.
3D structure databases
PDB
1E7P; X-ray; 3.10 A; B/E/H/K=1-239.[ExPASy / RCSB / EBI]
1QLB; X-ray; 2.33 A; B/E=1-239.[ExPASy / RCSB / EBI]
2BS2; X-ray; 1.78 A; B/E=1-239.[ExPASy / RCSB / EBI]
2BS3; X-ray; 2.19 A; B/E=1-239.[ExPASy / RCSB / EBI]
2BS4; X-ray; 2.76 A; B/E=1-239.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1E7P; -.
1QLB; -.
2BS2; -.
2BS3; -.
2BS4; -.
ModBase P17596.
Enzyme and pathway databases
BioCyc WSUC273121:WS0830-MON; -.
Family and domain databases
InterPro IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.
Gene3D G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF00037; Fer4; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
TIGRFAMs TIGR00384; dhsB; 1.
PROSITE PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P17596.
Genome annotation databases
GeneID 2555194; -.
GenomeReviews BX571656_GR; WS0830.
KEGG wsu:WS0830; -.
NMPDR fig|273121.1.peg.768; -.
Phylogenomic databases
HOGENOM P17596; -.
Genome annotation databases
CMR P17596; WS0830.
Other
ProtoNet P17596.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Respiratory chain; Transport; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   239  239     Fumarate reductase iron-sulfur subunit. PRO_0000158708
DOMAIN   5    95  91     2Fe-2S ferredoxin-type. 
DOMAIN   142   171  30     4Fe-4S ferredoxin-type. 
METAL   57    57        Iron-sulfur 1 (2Fe-2S). 
METAL   62    62        Iron-sulfur 1 (2Fe-2S). 
METAL   65    65        Iron-sulfur 1 (2Fe-2S). 
METAL   77    77        Iron-sulfur 1 (2Fe-2S). 
METAL   151   151        Iron-sulfur 2 (4Fe-4S). 
METAL   154   154        Iron-sulfur 2 (4Fe-4S). 
METAL   157   157        Iron-sulfur 2 (4Fe-4S). 
METAL   161   161        Iron-sulfur 3 (3Fe-4S). 
METAL   208   208        Iron-sulfur 3 (3Fe-4S). 
METAL   214   214        Iron-sulfur 3 (3Fe-4S). 
METAL   218   218        Iron-sulfur 2 (4Fe-4S). 
STRAND   4    11  8      
STRAND   22    29  8      
HELIX   36    46  11      
STRAND   58    62  5      
STRAND   66    69  4      
STRAND   72    75  4      
HELIX   76    78  3      
HELIX   81    83  3      
STRAND   87    92  6      
STRAND   97   101  5      
STRAND   104   106  3      
HELIX   108   117  10      
HELIX   139   149  11      
HELIX   156   159  4      
HELIX   162   166  5      
HELIX   172   183  12      
HELIX   192   199  8      
TURN   202   204  3      
HELIX   205   207  3      
HELIX   213   217  5      
HELIX   224   235  12      
Sequence information
Length: 239 AA [This is the length of the unprocessed precursor] Molecular weight: 27165 Da [This is the MW of the unprocessed precursor] CRC64: 24D1992489B8FFD1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRMLTIRVF KYDPQSAVSK PHFQEYKIEE APSMTIFIVL NMIRETYDPD LNFDFVCRAG 

        70         80         90        100        110        120 
ICGSCGMMIN GRPSLACRTL TKDFEDGVIT LLPLPAFKLI KDLSVDTGNW FNGMSQRVES 

       130        140        150        160        170        180 
WIHAQKEHDI SKLEERIEPE VAQEVFELDR CIECGCCIAA CGTKIMREDF VGAAGLNRVV 

       190        200        210        220        230 
RFMIDPHDER TDEDYYELIG DDDGVFGCMT LLACHDVCPK NLPLQSKIAY LRRKMVSVN 

P17596 in FASTA format

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