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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=2324105 [NCBI, ExPASy, EBI, Israel, Japan]
Haas R.C.,
Strauss A.W.;
"Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.";
J. Biol. Chem. 265:6921-6927(1990).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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PROTEIN SEQUENCE OF 40-65.
PubMed=2914937 [NCBI, ExPASy, EBI, Israel, Japan]
Haas R.C.,
Korenfeld C.,
Zhang Z.,
Perryman B.,
Roman D.,
Strauss A.W.;
"Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.";
J. Biol. Chem. 264:2890-2897(1989).
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[5]
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X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 27-416 IN COMPLEX WITH ADP.
Structural genomics consortium (SGC);
"Crystal structure of human sarcomeric mitochondrial creatine kinase.";
Submitted (APR-2006) to the PDB data bank.
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- FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
- SUBUNIT: Exists as an octamer composed of four CKMT2 homodimers.
- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
- TISSUE SPECIFICITY: Sarcomere-specific. Found only in heart and skeletal muscles.
- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin.
- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 419 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47504 Da [This is the MW of the unprocessed precursor] |
CRC64: 0CAF000074D99B6F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MASIFSKLLT GRNASLLFAT MGTSVLTTGY LLNRQKVCAE VREQPRLFPP SADYPDLRKH
70 80 90 100 110 120
NNCMAECLTP AIYAKLRNKV TPNGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA
130 140 150 160 170 180
DLFDPVIKLR HNGYDPRVMK HTTDLDASKI TQGQFDEHYV LSSRVRTGRS IRGLSLPPAC
190 200 210 220 230 240
TRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG
250 260 270 280 290 300
MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE
310 320 330 340 350 360
RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD
370 380 390 400 410
TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGKK
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P17540 in FASTA format |
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