[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-168. DOI=10.1016/0092-8674(90)90738-Z; PubMed=2153461 [NCBI, ExPASy, EBI, Israel, Japan] Uze G., Lutfalla G., Gresser I.; "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA."; Cell 60:225-234(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-168. PubMed=1370833 [NCBI, ExPASy, EBI, Israel, Japan] Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.; "The structure of the human interferon alpha/beta receptor gene."; J. Biol. Chem. 267:2802-2809(1992).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-168. TISSUE=Liver; Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.; Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-307 AND MET-359. SeattleSNPs variation discovery resource; Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). TISSUE=Brain, and Ovary; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[6]	NUCLEOTIDE SEQUENCE [MRNA] OF 398-514 (ISOFORM 3) AND 419-557 (ISOFORM 2), TISSUE SPECIFICITY, AND ALTERNATIVE SPLICING. TISSUE=Myeloma; DOI=10.1016/0014-5793(94)80287-4; PubMed=8307198 [NCBI, ExPASy, EBI, Israel, Japan] Abramovich C., Ratovitski E., Lundgren E., Revel M.; "Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor."; FEBS Lett. 338:295-300(1994).
[7]	PHOSPHORYLATION BY TYK2. PubMed=7526154 [NCBI, ExPASy, EBI, Israel, Japan] Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.; "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."; Mol. Cell. Biol. 14:8133-8142(1994).

Comments

FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
INTERACTION:
Q09472:EP300; NbExp=1; IntAct=EBI-1547250, EBI-447295;
SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	P17181-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	Sol-1, Soluble form 1
Isoform ID	P17181-2
Note: Incomplete sequence.
Features which should be applied to build the isoform sequence: VSP_029930, VSP_029931.

Name	3
Synonyms	Sol-2, Soluble form 2
Isoform ID	P17181-3
Note: Incomplete sequence.
Features which should be applied to build the isoform sequence: VSP_029928, VSP_029929.

TISSUE SPECIFICITY: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R, isoform 1 is not expressed in U266R.
PTM: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
SIMILARITY: Belongs to the type II cytokine receptor family.
SIMILARITY: Contains 3 fibronectin type-III domains.
SEQUENCE CAUTION:
- Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar1/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J03171; AAA52730.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60459; CAA42992.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222770; BAD96490.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222812; BAD96532.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY654286; AAT49100.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002590; AAH02590.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC021825; AAH21825.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00012877; -.
IPI00877141; -.
IPI00877162; -.

PIR

A32694; A32694.
S41602; S41602.

RefSeq

NP_000620.2; -.

UniGene

Hs.529400

3D structure databases

ModBase

P17181.

Protein-protein interaction databases

DIP

DIP:57N; -.

IntAct

P17181; 1.

PTM databases

PhosphoSite

P17181; -.

Enzyme and pathway databases

Pathway_Interaction_DB

cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.

Organism-specific databases

GC21P033619; -.

HIX0027789; -.

HGNC:5432; IFNAR1.

HPA018015; -.

107450; gene. [NCBI / EBI]

PharmGKB

PA29670; -.

Gene expression databases

P17181; -.

P17181; -.

HS_IFNAR1; -.

ENSG00000142166; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004905;	Molecular function: type I interferon receptor activity (traceable author statement from ProtInc).
GO:0007166;	Biological process: cell surface receptor linked signal transduction (traceable author statement from ProtInc).
GO:0007259;	Biological process: JAK-STAT cascade (traceable author statement from ProtInc).
GO:0009615;	Biological process: response to virus (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR016669; Interferon_alpha/beta_rcpt-1.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.30; FN_III-like; 2.

PIRSF

PIRSF016567; IFN_alpha/beta_recept-1; 1.

SMART

SM00060; FN3; 4.
SMART graphical view of domain structure.

PROSITE

PS50853; FN3; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P17181; -.

Genome annotation databases

Ensembl

ENSG00000142166; Homo sapiens. [Contig view]

GeneID

3454; -.

KEGG

hsa:3454; -.

Phylogenomic databases

HOGENOM

P17181; -.

HOVERGEN

P17181; -.

OMA

P17181; TSFWSEE.

Other

DrugBank

DB00034; Interferon Alfa-2a, Recombinant.
DB00105; Interferon Alfa-2b, Recombinant.
DB00011; Interferon alfa-n1.
DB00018; Interferon alfa-n3.
DB00069; Interferon alfacon-1.
DB00068; Interferon beta-1b.
DB00008; Peginterferon alfa-2a.
DB00022; Peginterferon alfa-2b.

NextBio

13606; -.

SOURCE

IFNAR1; Homo sapiens.

ProtoNet

P17181.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 27`	`27`	`Potential.`
`CHAIN`	`28 557`	`530`	`Interferon-alpha/beta receptor alpha chain.`	`PRO_0000011001`
`TOPO_DOM`	`28 436`	`409`	`Extracellular (Potential).`
`TRANSMEM`	`437 457`	`21`	`Potential.`
`TOPO_DOM`	`458 557`	`100`	`Cytoplasmic (Potential).`
`DOMAIN`	`134 224`	`91`	`Fibronectin type-III 1.`
`DOMAIN`	`230 326`	`97`	`Fibronectin type-III 2.`
`DOMAIN`	`334 425`	`92`	`Fibronectin type-III 3.`
`MOD_RES`	`466 466`		`Phosphotyrosine; by TYK2 (Probable).`
`MOD_RES`	`481 481`		`Phosphotyrosine; by TYK2 (Probable).`
`CARBOHYD`	`50 50`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`58 58`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`81 81`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`88 88`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`110 110`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`172 172`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`254 254`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`313 313`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`314 314`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`376 376`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`416 416`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`433 433`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`79 87`		`By similarity.`
`DISULFID`	`199 220`		`By similarity.`
`VAR_SEQ`	`414 421`		`Missing (in isoform 3).`	`VSP_029928`
`VAR_SEQ`	`428 480`		`Missing (in isoform 3).`	`VSP_029929`
`VAR_SEQ`	`428 434`		`KTKPGNT -> NISLNSH (in isoform 2).`	`VSP_029930`
`VAR_SEQ`	`435 557`		`Missing (in isoform 2).`	`VSP_029931`
`VARIANT`	`168 168`	`1`	`V -> L (in dbSNP:rs2257167 [NCBI]).`	`VAR_002717`
`VARIANT`	`307 307`	`1`	`V -> I (in dbSNP:rs17875833 [NCBI]).`	`VAR_020502`
`VARIANT`	`359 359`	`1`	`T -> M (in dbSNP:rs17875834 [NCBI]).`	`VAR_020503`
`CONFLICT`	`17 17`		`A -> G (in Ref. 1; AAA52730).`
`CONFLICT`	`59 59`		`V -> M (in Ref. 3; BAD96532).`
`CONFLICT`	`279 279`		`Q -> R (in Ref. 3; BAD96532).`
`CONFLICT`	`479 479`		`D -> N (in Ref. 3; BAD96532).`

Sequence information

Length: 557 AA [This is the length of the unprocessed precursor]

Molecular weight: 63525 Da [This is the MW of the unprocessed precursor]

CRC64: 24A01779DB7F356F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT 

        70         80         90        100        110        120 
FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF 

       130        140        150        160        170        180 
TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI 

       190        200        210        220        230        240 
ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ 

       250        260        270        280        290        300 
NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 

       310        320        330        340        350        360 
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP 

       370        380        390        400        410        420 
VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV 

       430        440        450        460        470        480 
FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE 

       490        500        510        520        530        540 
YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN 

       550 
EDESESKTSE ELQQDFV

P17181 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools