[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=2247069 [NCBI, ExPASy, EBI, Israel, Japan]
Williams F.E.,
Trumbly R.J.;
"Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.";
Mol. Cell. Biol. 10:6500-6511(1990).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(91)90047-F; PubMed=1900249 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang M.,
Rosenblum-Vos L.S.,
Lowry C.V.,
Boakye K.,
Zitomer R.S.;
"A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes.";
Gene 97:153-161(1991).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 44774 / DBY747;
DOI=10.1016/0378-1119(90)90210-I; PubMed=2197185 [NCBI, ExPASy, EBI, Israel, Japan]
Fujita A.,
Matsumoto S.,
Kuhara S.,
Misumi Y.,
Kobayashi H.;
"Cloning of the yeast SFL2 gene: its disruption results in pleiotropic phenotypes characteristic for tup1 mutants.";
Gene 89:93-99(1990).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1038/357038a0; PubMed=1574125 [NCBI, ExPASy, EBI, Israel, Japan]
Oliver S.G.,
van der Aart Q.J.M.,
Agostoni-Carbone M.L.,
Aigle M.,
Alberghina L.,
Alexandraki D.,
Antoine G.,
Anwar R.,
Ballesta J.P.G.,
Benit P.,
Berben G.,
Bergantino E.,
Biteau N.,
Bolle P.-A.,
Bolotin-Fukuhara M.,
Brown A.,
Brown A.J.P.,
Buhler J.-M.,
Carcano C.,
Carignani G.,
Cederberg H.,
Chanet R.,
Contreras R.,
Crouzet M.,
Daignan-Fornier B.,
Defoor E.,
Delgado M.D.,
Demolder J.,
Doira C.,
Dubois E.,
Dujon B.,
Duesterhoeft A.,
Erdmann D.,
Esteban M.,
Fabre F.,
Fairhead C.,
Faye G.,
Feldmann H.,
Fiers W.,
Francingues-Gaillard M.-C.,
Franco L.,
Frontali L.,
Fukuhara H.,
Fuller L.J.,
Galland P.,
Gent M.E.,
Gigot D.,
Gilliquet V.,
Glansdorff N.,
Goffeau A.,
Grenson M.,
Grisanti P.,
Grivell L.A.,
de Haan M.,
Haasemann M.,
Hatat D.,
Hoenicka J.,
Hegemann J.H.,
Herbert C.J.,
Hilger F.,
Hohmann S.,
Hollenberg C.P.,
Huse K.,
Iborra F.,
Indge K.J.,
Isono K.,
Jacq C.,
Jacquet M.,
James C.M.,
Jauniaux J.-C.,
Jia Y.,
Jimenez A.,
Kelly A.,
Kleinhans U.,
Kreisl P.,
Lanfranchi G.,
Lewis C.,
van der Linden C.G.,
Lucchini G.,
Lutzenkirchen K.,
Maat M.J.,
Mallet L.,
Mannhaupt G.,
Martegani E.,
Mathieu A.,
Maurer C.T.C.,
McConnell D.,
McKee R.A.,
Messenguy F.,
Mewes H.-W.,
Molemans F.,
Montague M.A.,
Muzi Falconi M.,
Navas L.,
Newlon C.S.,
Noone D.,
Pallier C.,
Panzeri L.,
Pearson B.M.,
Perea J.,
Philippsen P.,
Pierard A.,
Planta R.J.,
Plevani P.,
Poetsch B.,
Pohl F.M.,
Purnelle B.,
Ramezani Rad M.,
Rasmussen S.W.,
Raynal A.,
Remacha M.A.,
Richterich P.,
Roberts A.B.,
Rodriguez F.,
Sanz E.,
Schaaff-Gerstenschlaeger I.,
Scherens B.,
Schweitzer B.,
Shu Y.,
Skala J.,
Slonimski P.P.,
Sor F.,
Soustelle C.,
Spiegelberg R.,
Stateva L.I.,
Steensma H.Y.,
Steiner S.,
Thierry A.,
Thireos G.,
Tzermia M.,
Urrestarazu L.A.,
Valle G.,
Vetter I.,
van Vliet-Reedijk J.C.,
Voet M.,
Volckaert G.,
Vreken P.,
Wang H.,
Warmington J.R.,
von Wettstein D.,
Wicksteed B.L.,
Wilson C.,
Wurst H.,
Xu G.,
Yoshikawa A.,
Zimmermann F.K.,
Sgouros J.G.;
"The complete DNA sequence of yeast chromosome III.";
Nature 357:38-46(1992).
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[5]
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SIMILARITY TO BETA SUBUNIT OF G-PROTEINS.
DOI=10.1016/0378-1119(91)90118-U; PubMed=1901558 [NCBI, ExPASy, EBI, Israel, Japan]
Kearsley S.;
"The SFL2 (TUP1?) protein of Saccharomyces cerevisiae contains a repeating motif homologous to beta subunits of G proteins.";
Gene 98:147-148(1991).
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[6]
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INTERACTION WITH MATALPHA2.
PubMed=7995523 [NCBI, ExPASy, EBI, Israel, Japan]
Komachi K.,
Redd M.J.,
Johnson A.D.;
"The WD repeats of Tup1 interact with the homeo domain protein alpha 2.";
Genes Dev. 8:2857-2867(1994).
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[7]
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INTERACTION WITH HISTONE H3 AND HISTONE H4.
PubMed=8675011 [NCBI, ExPASy, EBI, Israel, Japan]
Edmondson D.G.,
Smith M.M.,
Roth S.Y.;
"Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.";
Genes Dev. 10:1247-1259(1996).
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[8]
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SUBUNIT.
PubMed=8943325 [NCBI, ExPASy, EBI, Israel, Japan]
Varanasi U.S.,
Klis M.,
Mikesell P.B.,
Trumbly R.J.;
"The Cyc8 (Ssn6)-Tup1 corepressor complex is composed of one Cyc8 and four Tup1 subunits.";
Mol. Cell. Biol. 16:6707-6714(1996).
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[9]
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INTERACTION WITH RFX1.
DOI=10.1016/S0092-8674(00)81601-3; PubMed=9741624 [NCBI, ExPASy, EBI, Israel, Japan]
Huang M.,
Zhou Z.,
Elledge S.J.;
"The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.";
Cell 94:595-605(1998).
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[10]
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INTERACTION WITH CYC8 AND RPD3, AND FUNCTION OF THE CYC8-TUP1 COMPLEX.
DOI=10.1101/gad.829100; PubMed=11069890 [NCBI, ExPASy, EBI, Israel, Japan]
Watson A.D.,
Edmondson D.G.,
Bone J.R.,
Mukai Y.,
Yu Y.,
Du W.,
Stillman D.J.,
Roth S.Y.;
"Ssn6-Tup1 interacts with class I histone deacetylases required for repression.";
Genes Dev. 14:2737-2744(2000).
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[11]
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INTERACTION WITH PGD1, AND FUNCTION OF THE CYC8-TUP1 COMPLEX.
DOI=10.1074/jbc.275.12.8397; PubMed=10722672 [NCBI, ExPASy, EBI, Israel, Japan]
Papamichos-Chronakis M.,
Conlan R.S.,
Gounalaki N.,
Copf T.,
Tzamarias D.;
"Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme.";
J. Biol. Chem. 275:8397-8403(2000).
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[12]
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FUNCTION OF THE CYC8-TUP1 COMPLEX.
DOI=10.1093/emboj/20.5.1123; PubMed=11230135 [NCBI, ExPASy, EBI, Israel, Japan]
Proft M.,
Pascual-Ahuir A.,
de Nadal E.,
Arino J.,
Serrano R.,
Posas F.;
"Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.";
EMBO J. 20:1123-1133(2001).
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[13]
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INTERACTION WITH SKO1.
DOI=10.1074/jbc.M105755200; PubMed=11500510 [NCBI, ExPASy, EBI, Israel, Japan]
Pascual-Ahuir A.,
Posas F.,
Serrano R.,
Proft M.;
"Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress.";
J. Biol. Chem. 276:37373-37378(2001).
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[14]
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INTERACTION WITH HDA1 AND HDA2, AND FUNCTION OF THE CYC8-TUP1 COMPLEX.
DOI=10.1016/S1097-2765(01)00160-5; PubMed=11172717 [NCBI, ExPASy, EBI, Israel, Japan]
Wu J.,
Suka N.,
Carlson M.,
Grunstein M.;
"TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast.";
Mol. Cell 7:117-126(2001).
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[15]
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FUNCTION OF THE CYC8-TUP1 COMPLEX.
PubMed=11784848 [NCBI, ExPASy, EBI, Israel, Japan]
Davie J.K.,
Trumbly R.J.,
Dent S.Y.;
"Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo.";
Mol. Cell. Biol. 22:693-703(2002).
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[16]
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FUNCTION OF THE CYC8-TUP1 COMPLEX.
DOI=10.1128/EC.2.6.1288-1303.2003; PubMed=14665463 [NCBI, ExPASy, EBI, Israel, Japan]
Mennella T.A.,
Klinkenberg L.G.,
Zitomer R.S.;
"Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.";
Eukaryot. Cell 2:1288-1303(2003).
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[17]
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INTERACTION WITH HOS1; HOS2 AND RPD3.
DOI=10.1074/jbc.M309753200; PubMed=14525981 [NCBI, ExPASy, EBI, Israel, Japan]
Davie J.K.,
Edmondson D.G.,
Coco C.B.,
Dent S.Y.;
"Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.";
J. Biol. Chem. 278:50158-50162(2003).
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[18]
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SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02026; PubMed=14562095 [NCBI, ExPASy, EBI, Israel, Japan]
Huh W.-K.,
Falvo J.V.,
Gerke L.C.,
Carroll A.S.,
Howson R.W.,
Weissman J.S.,
O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
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[19]
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LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S.,
Huh W.-K.,
Bower K.,
Howson R.W.,
Belle A.,
Dephoure N.,
O'Shea E.K.,
Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
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[20]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M400219-MCP200; PubMed=15665377 [NCBI, ExPASy, EBI, Israel, Japan]
Gruhler A.,
Olsen J.V.,
Mohammed S.,
Mortensen P.,
Faergeman N.J.,
Mann M.,
Jensen O.N.;
"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.";
Mol. Cell. Proteomics 4:310-327(2005).
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[21]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150; SER-216; THR-218; SER-253; SER-437; SER-438; SER-439; SER-441 AND SER-442, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M700468-MCP200; PubMed=18407956 [NCBI, ExPASy, EBI, Israel, Japan]
Albuquerque C.P.,
Smolka M.B.,
Payne S.H.,
Bafna V.,
Eng J.,
Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 282-713.
DOI=10.1093/emboj/19.12.3016; PubMed=10856245 [NCBI, ExPASy, EBI, Israel, Japan]
Sprague E.R.,
Redd M.J.,
Johnson A.D.,
Wolberger C.;
"Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.";
EMBO J. 19:3016-3027(2000).
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