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UniProtKB/Swiss-Prot entry P16422


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TACD1_HUMAN
Primary accession number P16422
Secondary accession numbers P18180 Q6FG26 Q6FG49 Q96C47 Q9UCD0
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on November 13, 2007 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 95)
Name and origin of the protein
Protein name Tumor-associated calcium signal transducer 1 [Precursor]
Synonyms Major gastrointestinal tumor-associated protein GA733-2
Epithelial cell surface antigen
Epithelial glycoprotein
EGP
Adenocarcinoma-associated antigen
KSA
KS 1/4 antigen
Cell surface glycoprotein Trop-1
CD326 antigen
Gene name
Name: TACSTD1
Synonyms: GA733-2, M1S2, M4S1, MIC18, TROP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
TISSUE=Lung adenocarcinoma;
PubMed=2463074 [NCBI, ExPASy, EBI, Israel, Japan]
Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D., Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.;
"Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA.";
Cancer Res. 49:314-317(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
PubMed=2469722 [NCBI, ExPASy, EBI, Israel, Japan]
Perez M.S., Walker L.E.;
"Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker.";
J. Immunol. 142:3662-3667(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
DOI=10.1073/pnas.87.7.2755; PubMed=2108441 [NCBI, ExPASy, EBI, Israel, Japan]
Simon B., Podolsky D.K., Moldenhauer G., Isselbacher K.J., Gattoni-Celli S., Brand S.J.;
"Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.";
Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Colon carcinoma;
DOI=10.1073/pnas.87.9.3542; PubMed=2333300 [NCBI, ExPASy, EBI, Israel, Japan]
Szala S., Froehlich M., Scollon M., Kasai Y., Steplewski Z., Koprowski H., Linnenbach A.J.;
"Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2.";
Proc. Natl. Acad. Sci. U.S.A. 87:3542-3546(1990).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Lymphoma;
PubMed=8382772 [NCBI, ExPASy, EBI, Israel, Japan]
Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.;
"Retroposition in a family of carcinoma-associated antigen genes.";
Mol. Cell. Biol. 13:1507-1515(1993).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-115.
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126.
TISSUE=Placenta;
DOI=10.1073/pnas.86.1.27; PubMed=2911574 [NCBI, ExPASy, EBI, Israel, Japan]
Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.;
"Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733.";
Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989).
[11]
PROTEIN SEQUENCE OF 82-100, AND SUBUNIT.
PubMed=7693697 [NCBI, ExPASy, EBI, Israel, Japan]
Bjoerk P., Joensson U., Svedberg H., Larsson K., Lind P., Dillner J., Hedlund G., Dohlsten M., Kalland T.;
"Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody.";
J. Biol. Chem. 268:24232-24241(1993).
[12]
DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-74 AND ASN-111.
DOI=10.1074/jbc.M008839200; PubMed=11080501 [NCBI, ExPASy, EBI, Israel, Japan]
Chong J.M., Speicher D.W.;
"Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM).";
J. Biol. Chem. 276:5804-5813(2001).
[13]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M32325; AAA36151.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X14758; CAA32870.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M26481; AAA59543.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M32306; AAA35723.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M33011; AAA35861.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93036; AAB00775.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93029; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93030; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93031; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93032; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93033; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93034; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93035; AAB00775.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR542259; CAG47055.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR542283; CAG47078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC079775; AAY15095.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471053; EAX00218.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014785; AAH14785.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00296215; -.
PIR B48149; B48149.
RefSeq NP_002345.2; -.
UniGene Hs.542050
3D structure databases
HSSP P04233; 1L3H. [HSSP ENTRY / PDB]
ModBase P16422.
Organism-specific databases
GeneCards GC02P047425; -.
H-InvDB HIX0002040; -.
HGNC HGNC:11529; TACSTD1.
GenAtlas TACSTD1.
HPA CAB003809; -.
MIM 185535; gene. [NCBI / EBI]
PharmGKB PA35493; -.
Gene expression databases
ArrayExpress P16422; -.
Bgee P16422; -.
CleanEx HS_EPCAM; -.
GermOnline ENSG00000119888; Homo sapiens.
Ontologies
GO
GO:0016324; Cellular component: apical plasma membrane (inferred from direct assay from MGI).
GO:0016323; Cellular component: basolateral plasma membrane (inferred from direct assay from MGI).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000716; Thyroglobulin_1.
Graphical view of domain structure.
Gene3D G3DSA:4.10.800.10; Thyroglobulin_1; 1.
Pfam PF00086; Thyroglobulin_1; 1.
Pfam graphical view of domain structure.
SMART SM00211; TY; 1.
SMART graphical view of domain structure.
PROSITE PS00484; THYROGLOBULIN_1_1; 1.
PS51162; THYROGLOBULIN_1_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P16422; -.
Genome annotation databases
Ensembl ENSG00000119888; Homo sapiens. [Contig view]
GeneID 4072; -.
Phylogenomic databases
HOGENOM P16422; -.
HOVERGEN P16422; -.
Other
SOURCE TACSTD1; Homo sapiens.
ProtoNet P16422.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Pyrrolidone carboxylic acid; Repeat; Signal; Transmembrane; Tumor antigen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    23  23     Potential. 
CHAIN   24   314  291     Tumor-associated calcium signal transducer 1. PRO_0000022467
TOPO_DOM   24   265  242     Extracellular (Potential). 
TRANSMEM   266   288  23     Potential. 
TOPO_DOM   289   314  26     Cytoplasmic (Potential). 
DOMAIN   63   135  73     Thyroglobulin type-1. 
MOD_RES   24    24        Pyrrolidone carboxylic acid (Probable). 
CARBOHYD   74    74        N-linked (GlcNAc...); partial. 
CARBOHYD   111   111        N-linked (GlcNAc...). 
CARBOHYD   198   198        N-linked (GlcNAc...). 
DISULFID   27    46         
DISULFID   29    59         
DISULFID   38    48         
DISULFID   66    99         
DISULFID   110   116         
DISULFID   118   135         
VARIANT   115   115  1     M -> T (in dbSNP:rs1126497 [NCBI]). VAR_018329 
CONFLICT   277   277        I -> M (in Ref. 1; AAA36151/CAA32870 and 2; AAA59543). 
CONFLICT   303   303        K -> R (in Ref. 6; CAG47055). 
Sequence information
Length: 314 AA [This is the length of the unprocessed precursor] Molecular weight: 34932 Da [This is the MW of the unprocessed precursor] CRC64: 023FCE418B2F1079 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS 

        70         80         90        100        110        120 
KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN 

       130        140        150        160        170        180 
TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF 

       190        200        210        220        230        240 
ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL 

       250        260        270        280        290        300 
DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 

       310 
EIKEMGEMHR ELNA 

P16422 in FASTA format

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