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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2045793 [NCBI, ExPASy, EBI, Israel, Japan]
Smith G.L.,
Chan Y.S.,
Howard S.T.;
"Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat.";
J. Gen. Virol. 72:1349-1376(1991).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/17.22.9051; PubMed=2555782 [NCBI, ExPASy, EBI, Israel, Japan]
Smith G.L.,
Chan Y.S.,
Kerr S.M.;
"Transcriptional mapping and nucleotide sequence of a vaccinia virus gene encoding a polypeptide with extensive homology to DNA ligases.";
Nucleic Acids Res. 17:9051-9062(1989).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Esposito J.J.,
Frace A.M.,
Sammons S.A.,
Olsen-Rasmussen M.,
Osborne J.,
Wohlhueter R.;
"Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
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[4]
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CHARACTERIZATION.
DOI=10.1093/nar/17.22.9039; PubMed=2587253 [NCBI, ExPASy, EBI, Israel, Japan]
Kerr S.M.,
Smith G.L.;
"Vaccinia virus encodes a polypeptide with DNA ligase activity.";
Nucleic Acids Res. 17:9039-9050(1989).
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[5]
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DOMAIN STRUCTURE.
DOI=10.1093/nar/25.4.727; PubMed=9016621 [NCBI, ExPASy, EBI, Israel, Japan]
Sekiguchi J.,
Shuman S.;
"Domain structure of vaccinia DNA ligase.";
Nucleic Acids Res. 25:727-734(1997).
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- FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA. It is not essential for viral replication and recombination.
- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 552 AA [This is the length of the unprocessed precursor] |
Molecular weight: 63360 Da [This is the MW of the unprocessed precursor] |
CRC64: 100F5210559F43DA [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTSLREFRKL CCDIYHASGY KEKSKLIRDF ITDRDDKYLI IKLLLPGLDD RIYNMNDKQI
70 80 90 100 110 120
IKLYSIIFKQ SQEDMLQDLG YGYIGDTIRT FFKENTEIRP RDKSILTLED VDSFLTTLSS
130 140 150 160 170 180
VTKESHQIKL LTDIASVCTC NDLKCVVMLI DKDLKIKAGP RYVLNAISPN AYDVFRKSNN
190 200 210 220 230 240
LKEIIENASK QNLDSISISV MTPINPMLAE SCDSVNKAFK KFPSGMFAEV KYDGERVQVH
250 260 270 280 290 300
KNNNEFAFFS RNMKPVLSHK VDYLKEYIPK AFKKATSIVL DSEIVLVDEH NVPLPFGSLG
310 320 330 340 350 360
IHKKKEYKNS NMCLFVFDCL YFDGFDMTDI PLYERRSFLK DVMVEIPNRI VFSELTNISN
370 380 390 400 410 420
ESQLTDVLDD ALTRKLEGLV LKDINGVYEP GKRRWLKIKR DYLNEGSMAD SADLVVLGAY
430 440 450 460 470 480
YGKGAKGGIM AVFLMGCYDD ESGKWKTVTK CSGHDDNTLR VLQDQLTMVK INKDPKKIPE
490 500 510 520 530 540
WLVVNKIYIP DFVVEDPKQS QIWEISGAEF TSSKSHTANG ISIRFPRFTR IREDKTWKES
550
THLNDLVNLT KS
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P16272 in FASTA format |
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