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UniProtKB/Swiss-Prot entry P16240


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CION_CIOIN
Primary accession number P16240
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on June 1, 1994 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name Cionin [Precursor]
Synonyms None
Gene name None
From
Ciona intestinalis (Transparent sea squirt) [TaxID: 7719] 
Taxonomy Eukaryota; Metazoa; Chordata; Urochordata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0014-5793(93)80297-8; PubMed=8405412 [NCBI, ExPASy, EBI, Israel, Japan]
Monstein H.J., Thorup J.U., Folkesson R., Johnsen A.H., Rehfeld J.F.;
"cDNA deduced procionin. Structure and expression in protochordates resemble that of procholecystokinin in mammals.";
FEBS Lett. 331:60-64(1993).
[2]
PROTEIN SEQUENCE OF 109-116.
TISSUE=Neural ganglion;
PubMed=2303439 [NCBI, ExPASy, EBI, Israel, Japan]
Johnsen A.H., Rehfeld J.F.;
"Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis.";
J. Biol. Chem. 265:3054-3058(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X69130; CAA48884.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S36901; S36901.
RefSeq NP_001027711.1; -.
UniGene Cin.14237
3D structure databases
ModBase P16240.
Family and domain databases
InterPro IPR015499; CCK.
IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.
PANTHER PTHR10786; CCK; 1.
Pfam PF00918; Gastrin; 1.
Pfam graphical view of domain structure.
SMART SM00029; GASTRIN; 1.
SMART graphical view of domain structure.
PROSITE PS00259; GASTRIN; 1.
BLOCKS P16240.
Genome annotation databases
GeneID 445737; -.
Phylogenomic databases
HOVERGEN P16240; -.
Other
ProtoNet P16240.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Neuropeptide; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
PROPEP   23   108  86      PRO_0000010671
PEPTIDE   109   116  8     Cionin. PRO_0000010672
PROPEP   120   128  9      PRO_0000010673
MOD_RES   110   110        Sulfotyrosine. 
MOD_RES   111   111        Sulfotyrosine. 
MOD_RES   116   116        Phenylalanine amide. 
Sequence information
Length: 128 AA [This is the length of the unprocessed precursor] Molecular weight: 14820 Da [This is the MW of the unprocessed precursor] CRC64: BF1DE73438E66609 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGSNIVIYFS IIVIVTLNVN GVPASDLFKS VSQYHIPRSK VINKETVTKP LQFQRAICRL 

        70         80         90        100        110        120 
LQKLGEETFA RLSQSELEAK QLDLIKTCYQ ANSFGDNENQ GHMQRMDRNY YGWMDFGKRA 


IEDVDYEY 

P16240 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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