[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1073/pnas.86.14.5552; PubMed=2501791 [NCBI, ExPASy, EBI, Israel, Japan] Hollis G.F., Evans R.J., Stafford-Hollis J.M., Korsmeyer S.J., McKearn J.P.; "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein."; Proc. Natl. Acad. Sci. U.S.A. 86:5552-5556(1989).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. TISSUE=Lymphoid; DOI=10.1084/jem.173.2.305; PubMed=1703205 [NCBI, ExPASy, EBI, Israel, Japan] Evans R.J., Hollis G.F.; "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."; J. Exp. Med. 173:305-311(1991).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-193. DOI=10.1093/intimm/2.3.201; PubMed=2128466 [NCBI, ExPASy, EBI, Israel, Japan] Schiff C., Bensmana M., Guglielmi P., Milili M., Lefranc M.-P., Fougereau M.; "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene."; Int. Immunol. 2:201-207(1990).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-213. DOI=10.1084/jem.163.2.425; PubMed=3003227 [NCBI, ExPASy, EBI, Israel, Japan] Chang H., Dmitrovsky E., Hieter P.A., Mitchell K., Leder P., Turoczi L., Kirsch I.R., Hollis G.F.; "Identification of three new Ig lambda-like genes in man."; J. Exp. Med. 163:425-435(1986).
[6]	VARIANT AUTOSOMAL RECESSIVE NON-BRUTON TYPE AGAMMAGLOBULINEMIA LEU-142. DOI=10.1084/jem.187.1.71; PubMed=9419212 [NCBI, ExPASy, EBI, Israel, Japan] Minegishi Y., Coustan-Smith E., Wang Y.H., Cooper M.D., Campana D., Conley M.E.; "Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia."; J. Exp. Med. 187:71-77(1998).

Comments

SUBUNIT: Associates non-covalently with VPREB1.
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).
DISEASE: Defects in IGLL1 are a cause of autosomal recessive non-Bruton type agammaglobulinemia [MIM:601495]. It is characterized by agammaglobulinemia and markedly reduced numbers of B cells.
SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
WEB RESOURCE: Name=IGLL1base; Note=IGLL1 mutation db; URL="http://bioinf.uta.fi/IGLL1base/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M27749; AAA36100.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M34513; AAA36096.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M34511; AAA36096.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M34512; AAA36096.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012293; AAH12293.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X03528; CAA27229.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X03530; CAA27231.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00013438; -.

PIR

A33911; A33911.

RefSeq

NP_064455.1; -.
NP_690594.1; -.

UniGene

Hs.348935

3D structure databases

PDB

2H32; X-ray; 2.70 A; B=93-213.	[ExPASy / RCSB / EBI]
2H3N; X-ray; 2.30 A; B/D=94-209.	[ExPASy / RCSB / EBI]
3BJ9; X-ray; 2.00 A; 1=95-108.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

2H32; -.
2H3N; -.
3BJ9; -.

ModBase

P15814.

Organism-specific databases

GeneCards

GC22M022239; -.

H-InvDB

HIX0021178; -.
HIX0039894; -.

HGNC:5870; IGLL1.

146770; gene. [NCBI / EBI]
601495; phenotype. [NCBI / EBI]

Orphanet

33110; Autosomal recessive agammaglobulinemia.

PharmGKB

PA29756; -.

Gene expression databases

P15814; -.

P15814; -.

HS_IGLL1; -.

ENSG00000128322; Homo sapiens.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016020;	Cellular component: membrane (non-traceable author statement from UniProtKB).
GO:0006955;	Biological process: immune response (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR003597; Ig_C1-set.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 1.

Pfam

PF07654; C1-set; 1.
Pfam graphical view of domain structure.

SMART

SM00407; IGc1; 1.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 1.
PS00290; IG_MHC; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PeptideAtlas

P15814; -.

PRIDE

P15814; -.

Genome annotation databases

Ensembl

ENSG00000128322; Homo sapiens. [Contig view]

GeneID

3543; -.

KEGG

hsa:3543; -.

Phylogenomic databases

HOGENOM

P15814; -.

HOVERGEN

P15814; -.

OMA

P15814; MHEGSTV.

Other

13836; -.

IGLL1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Disease mutation; Disulfide bond; Immunoglobulin domain; Polymorphism; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 37`	`37`	`Potential.`
`CHAIN`	`38 213`	`176`	`Immunoglobulin lambda-like polypeptide 1.`	`PRO_0000014777`
`DOMAIN`	`114 208`	`95`	`Ig-like C1-type.`
`REGION`	`97 108`	`12`	`J region (By similarity to lambda light-chain).`
`REGION`	`109 213`	`105`	`C region (By similarity to lambda light-chain).`
`DISULFID`	`135 194`		`By similarity.`
`DISULFID`	`212 212`		`Interchain (with a heavy chain) (By similarity).`
`VARIANT`	`120 120`	`1`	`P -> L (in dbSNP:rs1064425 [NCBI]).`	`VAR_049878 [3D]`
`VARIANT`	`142 142`	`1`	`P -> L (in autosomal recessive non-Bruton type agammaglobulinemia; dbSNP:rs1064422 [NCBI]).`	`VAR_034869 [3D]`
`STRAND`	`102 108`	`7`
`STRAND`	`115 119`	`5`
`HELIX`	`123 126`	`4`
`TURN`	`127 129`	`3`
`STRAND`	`131 143`	`13`
`STRAND`	`146 151`	`6`
`STRAND`	`158 162`	`5`
`STRAND`	`173 181`	`9`
`HELIX`	`183 188`	`6`
`STRAND`	`192 198`	`7`
`STRAND`	`201 207`	`7`

Sequence information

Length: 213 AA [This is the length of the unprocessed precursor]

Molecular weight: 22963 Da [This is the MW of the unprocessed precursor]

CRC64: 9133A7742B943C79 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRPGTGQGGL EAPGEPGPNL RQRWPLLLLG LAVVTHGLLR PTAASQSRAL GPGAPGGSSR 

        70         80         90        100        110        120 
SSLRSRWGRF LLQRGSWTGP RCWPRGFQSK HNSVTHVFGS GTQLTVLSQP KATPSVTLFP 

       130        140        150        160        170        180 
PSSEELQANK ATLVCLMNDF YPGILTVTWK ADGTPITQGV EMTTPSKQSN NKYAASSYLS 

       190        200        210 
LTPEQWRSRR SYSCQVMHEG STVEKTVAPA ECS

P15814 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools