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UniProtKB/Swiss-Prot entry P15248


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL9_HUMAN
Primary accession number P15248
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on April 1, 1990 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 89)
Name and origin of the protein
Protein name Interleukin-9 [Precursor]
Synonyms IL-9
T-cell growth factor P40
P40 cytokine
Gene name
Name: IL9
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2508790 [NCBI, ExPASy, EBI, Israel, Japan]
Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.;
"Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40.";
Blood 74:1880-1884(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/1043-4666(90)90037-T; PubMed=2129501 [NCBI, ExPASy, EBI, Israel, Japan]
Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.;
"Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40.";
Cytokine 2:9-12(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1971295 [NCBI, ExPASy, EBI, Israel, Japan]
Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.;
"Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.";
J. Immunol. 144:4235-4241(1990).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Leukocyte;
PubMed=1901233 [NCBI, ExPASy, EBI, Israel, Japan]
Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.;
"Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells.";
Blood 77:1436-1441(1991).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-117.
SeattleSNPs variation discovery resource;
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02919; PubMed=15372022 [NCBI, ExPASy, EBI, Israel, Japan]
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M30134; AAA36400.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X17543; CAA35581.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S63356; AAB19823.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M30135; AAA35887.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M86593; AAA59161.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF361105; AAK26666.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002428; AAB66904.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004763; AAC17735.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066283; AAH66283.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066285; AAH66285.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066286; AAH66286.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00010780; -.
PIR A60480; A60480.
RefSeq NP_000581.1; -.
UniGene Hs.960
3D structure databases
ModBase P15248.
Protein-protein interaction databases
DIP DIP:3155N; -.
PTM databases
PhosphoSite P15248; -.
Organism-specific databases
GeneCards GC05M135255; -.
H-InvDB HIX0032077; -.
HGNC HGNC:6029; IL9.
GenAtlas IL9.
MIM 146931; gene. [NCBI / EBI]
PharmGKB PA29845; -.
Gene expression databases
ArrayExpress P15248; -.
Bgee P15248; -.
CleanEx HS_IL9; -.
GermOnline ENSG00000145839; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005125; Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005126; Molecular function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding (inferred from electronic annotation from InterPro).
GO:0006955; Biological process: immune response (inferred from electronic annotation from InterPro).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
GO:0008284; Biological process: positive regulation of cell proliferation (traceable author statement from ProtInc).
GO:0045407; Biological process: positive regulation of interleukin-5 biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR018049; Interleukin-7/-9_CS.
IPR000226; Interleukin_7_9.
Graphical view of domain structure.
Pfam PF01415; IL7; 1.
Pfam graphical view of domain structure.
ProDom PD033324; Interleukin_9; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00255; INTERLEUKIN_7_9; 1.
Proteomic databases
PRIDE P15248; -.
Genome annotation databases
Ensembl ENSG00000145839; Homo sapiens. [Contig view]
GeneID 3578; -.
KEGG hsa:3578; -.
Phylogenomic databases
HOGENOM P15248; -.
HOVERGEN P15248; -.
OMA P15248; KEKMRGM.
Other
NextBio 13986; -.
SOURCE IL9; Homo sapiens.
ProtoNet P15248.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Glycoprotein; Growth factor; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   144  126     Interleukin-9. PRO_0000015627
CARBOHYD   50    50        N-linked (GlcNAc...) (Potential). 
CARBOHYD   63    63        N-linked (GlcNAc...) (Potential). 
CARBOHYD   78    78        N-linked (GlcNAc...) (Potential). 
CARBOHYD   114   114        N-linked (GlcNAc...) (Potential). 
VARIANT   117   117  1     T -> M (in dbSNP:rs2069885 [NCBI]). VAR_013079 
Sequence information
Length: 144 AA [This is the length of the unprocessed precursor] Molecular weight: 15909 Da [This is the MW of the unprocessed precursor] CRC64: 2EAA08690558ECAB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP 

        70         80         90        100        110        120 
SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN 

       130        140 
ALTFLKSLLE IFQKEKMRGM RGKI 

P15248 in FASTA format

View entry in raw text format (no links)
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