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UniProtKB/Swiss-Prot entry P15173

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MYOG_HUMAN
Primary accession number P15173
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on December 1, 1992 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 83)
Name and origin of the protein
Protein name Myogenin
Synonyms Myogenic factor 4
Myf-4
Gene name
Name: MYOG
Synonyms: MYF4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=2583111 [NCBI, ExPASy, EBI, Israel, Japan]
Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H., Arnold H.H.;
"Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.";
EMBO J. 8:3617-3625(1989).
[2]
 ERRATUM, AND SEQUENCE REVISION.
Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H., Arnold H.H.;
EMBO J. 9:592-592(1990).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1083/jcb.115.4.905; PubMed=1659574 [NCBI, ExPASy, EBI, Israel, Japan]
Salminen A., Braun T., Buchberger A., Juers S., Winter B., Arnold H.H.;
"Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins.";
J. Cell Biol. 115:905-917(1991).
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X17651; CAA35641.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X62155; CAA44080.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC053899; AAH53899.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00010313; -.
PIR A41128; A41128.
RefSeq NP_002470.2; -.
UniGene Hs.2830
3D structure databases
HSSP P10085; 1MDY. [HSSP ENTRY / PDB]
SMR P15173; 74-136.
ModBase P15173.
Protein-protein interaction databases
DIP DIP:159N; -.
PTM databases
PhosphoSite P15173; -.
Organism-specific databases
GeneCards GC01M201318; -.
H-InvDB HIX0023649; -.
HGNC HGNC:7612; MYOG.
GenAtlas MYOG.
MIM 159980; gene. [NCBI / EBI]
PharmGKB PA31417; -.
Gene expression databases
ArrayExpress P15173; -.
Bgee P15173; -.
CleanEx HS_MYOG; -.
GermOnline ENSG00000122180; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003700; Molecular function: transcription factor activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002546; Basic.
IPR001092; HLH_basic.
IPR011598; HLH_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:4.10.280.10; HLH_DNA_bd; 1.
Pfam PF01586; Basic; 1.
PF00010; HLH; 1.
Pfam graphical view of domain structure.
SMART SM00520; BASIC; 1.
SM00353; HLH; 1.
SMART graphical view of domain structure.
PROSITE PS50888; HLH; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000122180; Homo sapiens. [Contig view]
GeneID 4656; -.
KEGG hsa:4656; -.
Phylogenomic databases
HOGENOM P15173; -.
HOVERGEN P15173; -.
OMA P15173; ARGPLED.
Other
NextBio 17946; -.
SOURCE MYOG; Homo sapiens.
ProtoNet P15173.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   224  224     Myogenin. PRO_0000127375
DOMAIN   94   133  40     Helix-loop-helix motif. 
DNA_BIND   81    93  13     Basic motif. 
Sequence information
Length: 224 AA [This is the length of the unprocessed precursor] Molecular weight: 25037 Da [This is the MW of the unprocessed precursor] CRC64: 91421D69B57551FB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL EDKGLGTPEH 

        70         80         90        100        110        120 
CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE 

       130        140        150        160        170        180 
ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPGVPS ECSSHSASCS PEWGSALEFS 

       190        200        210        220 
ANPGDHLLTA DPTDAHNLHS LTSIVDSITV EDVSVAFPDE TMPN
P15173 in FASTA format

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