[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=2498333 [NCBI, ExPASy, EBI, Israel, Japan]
Bohren K.M.,
Bullock B.,
Wermuth B.,
Gabbay K.H.;
"The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.";
J. Biol. Chem. 264:9547-9551(1989).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=2504709 [NCBI, ExPASy, EBI, Israel, Japan]
Chung S.,
Lamendola J.;
"Cloning and sequence determination of human placental aldose reductase gene.";
J. Biol. Chem. 264:14775-14777(1989).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetus;
DOI=10.1093/nar/17.20.8368; PubMed=2510130 [NCBI, ExPASy, EBI, Israel, Japan]
Graham A.,
Hedge P.J.,
Powell S.J.,
Riley J.,
Brown L.,
Gammack A.,
Carey F.,
Markham A.F.;
"Nucleotide sequence of cDNA for human aldose reductase.";
Nucleic Acids Res. 17:8368-8368(1989).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Placenta;
PubMed=2111143 [NCBI, ExPASy, EBI, Israel, Japan]
Grundmann U.,
Bohn H.,
Obermeier R.,
Amann E.;
"Cloning and prokaryotic expression of a biologically active human placental aldose reductase.";
DNA Cell Biol. 9:149-157(1990).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2112546 [NCBI, ExPASy, EBI, Israel, Japan]
Nishimura C.,
Matsuura Y.,
Kokai Y.,
Akera T.,
Carper D.,
Morjana N.,
Lyons C.,
Flynn T.G.;
"Cloning and expression of human aldose reductase.";
J. Biol. Chem. 265:9788-9792(1990).
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1901857 [NCBI, ExPASy, EBI, Israel, Japan]
Graham A.,
Brown L.,
Hedge P.J.,
Gammack A.J.,
Markham A.F.;
"Structure of the human aldose reductase gene.";
J. Biol. Chem. 266:6872-6877(1991).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1074/jbc.272.26.16431; PubMed=9195951 [NCBI, ExPASy, EBI, Israel, Japan]
Ko B.C.B.,
Ruepp B.,
Bohren K.M.,
Gabbay K.H.,
Chung S.S.;
"Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.";
J. Biol. Chem. 272:16431-16437(1997).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphoma;
DOI=10.1111/j.1365-2133.2004.05651.x; PubMed=14996095 [NCBI, ExPASy, EBI, Israel, Japan]
Hartmann T.B.,
Thiel D.,
Dummer R.,
Schadendorf D.,
Eichmueller S.;
"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.";
Br. J. Dermatol. 150:252-258(2004).
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1083423; PubMed=12690205 [NCBI, ExPASy, EBI, Israel, Japan]
Scherer S.W.,
Cheung J.,
MacDonald J.R.,
Osborne L.R.,
Nakabayashi K.,
Herbrick J.-A.,
Carson A.R.,
Parker-Katiraee L.,
Skaug J.,
Khaja R.,
Zhang J.,
Hudek A.K.,
Li M.,
Haddad M.,
Duggan G.E.,
Fernandez B.A.,
Kanematsu E.,
Gentles S.,
Christopoulos C.C., ![]()
Choufani S.,
Kwasnicka D.,
Zheng X.H.,
Lai Z.,
Nusskern D.R.,
Zhang Q.,
Gu Z.,
Lu F.,
Zeesman S.,
Nowaczyk M.J.,
Teshima I.,
Chitayat D.,
Shuman C.,
Weksberg R.,
Zackai E.H.,
Grebe T.A.,
Cox S.R.,
Kirkpatrick S.J.,
Rahman N.,
Friedman J.M.,
Heng H.H.Q.,
Pelicci P.G.,
Lo-Coco F.,
Belloni E.,
Shaffer L.G.,
Pober B.,
Morton C.C.,
Gusella J.F.,
Bruns G.A.P.,
Korf B.R.,
Quade B.J.,
Ligon A.H.,
Ferguson H.,
Higgins A.W.,
Leach N.T.,
Herrick S.R.,
Lemyre E.,
Farra C.G.,
Kim H.-G.,
Summers A.M.,
Gripp K.W.,
Roberts W.,
Szatmari P.,
Winsor E.J.T.,
Grzeschik K.-H.,
Teebi A.,
Minassian B.A.,
Kere J.,
Armengol L.,
Pujana M.A.,
Estivill X.,
Wilson M.D.,
Koop B.F.,
Tosi S.,
Moore G.E.,
Boright A.P.,
Zlotorynski E.,
Kerem B.,
Kroisel P.M.,
Petek E.,
Oscier D.G.,
Mould S.J.,
Doehner H.,
Doehner K.,
Rommens J.M.,
Vincent J.B.,
Venter J.C.,
Li P.W.,
Mural R.J.,
Adams M.D.,
Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
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[11]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, Eye, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[12]
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PROTEIN SEQUENCE OF 131-162, AND TISSUE SPECIFICITY.
DOI=10.1016/0167-4889(93)90218-E; PubMed=8435445 [NCBI, ExPASy, EBI, Israel, Japan]
Ferraretto A.,
Negri A.,
Giuliani A.,
De Grada L.,
Fuhrman Conti A.M.,
Ronchi S.;
"Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress.";
Biochim. Biophys. Acta 1175:283-288(1993).
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[13]
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PROTEIN SEQUENCE OF 244-275.
PubMed=2492527 [NCBI, ExPASy, EBI, Israel, Japan]
Morjana N.A.,
Lyons C.,
Flynn T.G.;
"Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine.";
J. Biol. Chem. 264:2912-2919(1989).
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[14]
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PROTEIN SEQUENCE OF 276-294, AND MASS SPECTROMETRY.
TISSUE=Brain, and Cajal-Retzius cell;
Lubec G.,
Vishwanath V.;
Submitted (MAR-2007) to UniProtKB.
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[15]
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PROTEIN SEQUENCE OF 298-316, AND ENZYME REGULATION.
DOI=10.1016/0167-4838(93)90258-S; PubMed=8343525 [NCBI, ExPASy, EBI, Israel, Japan]
Liu S.Q.,
Bhatnagar A.,
Ansari N.H.,
Srivastava S.K.;
"Identification of the reactive cysteine residue in human placenta aldose reductase.";
Biochim. Biophys. Acta 1164:268-272(1993).
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[16]
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PARTIAL PROTEIN SEQUENCE, AND ACETYLATION AT ALA-2.
TISSUE=Muscle;
PubMed=8281941 [NCBI, ExPASy, EBI, Israel, Japan]
Jaquinod M.,
Potier N.,
Klarskov K.,
Reymann J.-M.,
Sorokine O.,
Kieffer S.,
Barth P.,
Andriantomanga V.,
Biellmann J.-F.,
van Dorsselaer A.;
"Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes.";
Eur. J. Biochem. 218:893-903(1993).
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[17]
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MUTAGENESIS OF ASP-44; TYR-49; LYS-78 AND HIS-111.
PubMed=8245005 [NCBI, ExPASy, EBI, Israel, Japan]
Tarle I.,
Borhani D.W.,
Wilson D.K.,
Quiocho F.A.,
Petrash J.M.;
"Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.";
J. Biol. Chem. 268:25687-25693(1993).
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[18]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND TYR-40, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K.,
Sugiyama N.,
Kyono Y.,
Tomita M.,
Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
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[19]
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X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
PubMed=1621098 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson D.K.,
Bohren K.M.,
Gabbay K.H.,
Quiocho F.A.;
"An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.";
Science 257:81-84(1992).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS).
PubMed=1447221 [NCBI, ExPASy, EBI, Israel, Japan]
Borhani D.W.,
Harter T.M.,
Pertrash J.M.;
"The crystal structure of the aldose reductase.NADPH binary complex.";
J. Biol. Chem. 267:24841-24847(1992).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
PubMed=8234324 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson D.K.,
Tarle I.,
Petrash J.M.,
Quiocho F.A.;
"Refined 1.8-A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.";
Proc. Natl. Acad. Sci. U.S.A. 90:9847-9851(1993).
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[22]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
DOI=10.1021/bi9717136; PubMed=9405046 [NCBI, ExPASy, EBI, Israel, Japan]
Harrison D.H.,
Bohren K.M.,
Petsko G.A.,
Ringe D.,
Gabbay K.H.;
"The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.";
Biochemistry 36:16134-16140(1997).
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[23]
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X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR, AND ACTIVE SITE.
DOI=10.1107/S0907444904011370; PubMed=15272156 [NCBI, ExPASy, EBI, Israel, Japan]
Ruiz F.,
Hazemann I.,
Mitschler A.,
Joachimiak A.,
Schneider T.,
Karplus M.,
Podjarny A.;
"The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.";
Acta Crystallogr. D 60:1347-1354(2004).
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[24]
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X-RAY CRYSTALLOGRAPHY (0.66 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR.
DOI=10.1002/prot.20015; PubMed=15146478 [NCBI, ExPASy, EBI, Israel, Japan]
Howard E.I.,
Sanishvili R.,
Cachau R.E.,
Mitschler A.,
Chevrier B.,
Barth P.,
Lamour V.,
Van Zandt M.,
Sibley E.,
Bon C.,
Moras D.,
Schneider T.R.,
Joachimiak A.,
Podjarny A.;
"Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.";
Proteins 55:792-804(2004).
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[25]
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X-RAY CRYSTALLOGRAPHY (0.95 ANGSTROMS) IN COMPLEX WITH NADP AND SUBSTRATE ANALOG.
DOI=10.1016/j.jmb.2005.10.067; PubMed=16337231 [NCBI, ExPASy, EBI, Israel, Japan]
Steuber H.,
Zentgraf M.,
Podjarny A.,
Heine A.,
Klebe G.;
"High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.";
J. Mol. Biol. 356:45-56(2006).
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[26]
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X-RAY CRYSTALLOGRAPHY (0.82 ANGSTROMS) IN COMPLEX WITH NADP.
DOI=10.1107/S0907444907011997; PubMed=17505104 [NCBI, ExPASy, EBI, Israel, Japan]
Biadene M.,
Hazemann I.,
Cousido A.,
Ginell S.,
Joachimiak A.,
Sheldrick G.M.,
Podjarny A.,
Schneider T.R.;
"The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.";
Acta Crystallogr. D 63:665-672(2007).
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[27]
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X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR.
DOI=10.1016/j.jmb.2007.03.021; PubMed=17418233 [NCBI, ExPASy, EBI, Israel, Japan]
Steuber H.,
Zentgraf M.,
La Motta C.,
Sartini S.,
Heine A.,
Klebe G.;
"Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.";
J. Mol. Biol. 369:186-197(2007).
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[28]
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X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR.
DOI=10.1016/j.jmb.2006.12.004; PubMed=17368668 [NCBI, ExPASy, EBI, Israel, Japan]
Steuber H.,
Heine A.,
Klebe G.;
"Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.";
J. Mol. Biol. 368:618-638(2007).
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