[1]
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NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND PHOSPHORYLATION AT THR-373.
TISSUE=Testis;
PubMed=1508179 [NCBI, ExPASy, EBI, Israel, Japan]
Stephens R.M.,
Sithanandam G.,
Copeland T.D.,
Kaplan D.R.,
Rapp U.R.,
Morrison D.K.;
"95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site.";
Mol. Cell. Biol. 12:3733-3742(1992).
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[2]
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SEQUENCE REVISION TO 31-33.
Albert S.,
Wixler L.,
Rapp U.R.;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Fulton R.S.,
Fulton L.A.,
Graves T.A.,
Pepin K.H.,
Wagner-McPherson C.,
Layman D.,
Maas J.,
Jaeger S.,
Walker R.,
Wylie K.,
Sekhon M.,
Becker M.C.,
O'Laughlin M.D.,
Schaller M.E.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E., ![]()
Cordes M.,
Du H.,
Sun H.,
Edwards J.,
Bradshaw-Cordum H.,
Ali J.,
Andrews S.,
Isak A.,
Vanbrunt A.,
Nguyen C.,
Du F.,
Lamar B.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Bielicki L.,
Scott K.,
Holmes A.,
Harkins R.,
Harris A.,
Strong C.M.,
Hou S.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Leonard S.,
Rohlfing T.,
Rock S.M.,
Tin-Wollam A.-M.,
Abbott A.,
Minx P.,
Maupin R.,
Strowmatt C.,
Latreille P.,
Miller N.,
Johnson D.,
Murray J.,
Woessner J.P.,
Wendl M.C.,
Yang S.-P.,
Schultz B.R.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Nelson J.O.,
Berkowicz N.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Bedell J.A.,
Mardis E.R.,
Clifton S.W.,
Chissoe S.L.,
Marra M.A.,
Raymond C.,
Haugen E.,
Gillett W.,
Zhou Y.,
James R.,
Phelps K.,
Iadanoto S.,
Bubb K.,
Simms E.,
Levy R.,
Clendenning J.,
Kaul R.,
Kent W.J.,
Furey T.S.,
Baertsch R.A.,
Brent M.R.,
Keibler E.,
Flicek P.,
Bork P.,
Suyama M.,
Bailey J.A.,
Portnoy M.E.,
Torrents D.,
Chinwalla A.T.,
Gish W.R.,
Eddy S.R.,
McPherson J.D.,
Olson M.V.,
Eichler E.E.,
Green E.D.,
Waterston R.H.,
Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-200.
TISSUE=Placenta;
PubMed=1630826 [NCBI, ExPASy, EBI, Israel, Japan]
Eychene A.,
Barnier J.V.,
Apiou F.,
Dutrillaux B.,
Calothy G.;
"Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.";
Oncogene 7:1657-1660(1992).
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[6]
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PROTEIN SEQUENCE OF 2-51; 56-95; 151-158; 189-199; 253-260; 294-354; 361-424; 444-507; 510-522; 559-570; 579-626; 663-680; 692-698; 702-719; 727-735 AND 753-766, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-365; THR-396; SER-399; THR-401 AND SER-729, AND MASS SPECTROMETRY.
TISSUE=Colon carcinoma, and Hepatoma;
Bienvenut W.V.,
Boldt K.,
von Kriegsheim A.F.,
Zebisch A.,
Kolch W.;
Submitted (DEC-2008) to UniProtKB.
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 117-766.
TISSUE=Testis;
PubMed=2284096 [NCBI, ExPASy, EBI, Israel, Japan]
Sithanandam G.,
Kolch W.,
Duh F.-M.,
Rapp U.R.;
"Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.";
Oncogene 5:1775-1780(1990).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] OF 439-766.
PubMed=3043188 [NCBI, ExPASy, EBI, Israel, Japan]
Ikawa S.,
Fukui M.,
Ueyama Y.,
Tamaoki N.,
Yamamoto T.,
Toyoshima K.;
"B-raf, a new member of the raf family, is activated by DNA rearrangement.";
Mol. Cell. Biol. 8:2651-2654(1988).
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[9]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-401 AND SER-729, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-401, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Villen J.,
Gerber S.A.,
Rush J.,
Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151; SER-365; THR-401; SER-419; SER-446; SER-729 AND SER-750, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J.,
Jaensch L.,
Nimtz M.,
Dieterich G.,
Hornberger R.,
Keri G.,
Wehland J.,
Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-373, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T.,
Yi W.,
Lu B.,
Park S.K.,
Xu T.,
Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
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[14]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[15]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-401; SER-446; SER-447 AND SER-729, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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[16]
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VARIANTS LUNG CANCER VAL-466 AND ARG-597.
PubMed=12460919 [NCBI, ExPASy, EBI, Israel, Japan]
Naoki K.,
Chen T.-H.,
Richards W.G.,
Sugarbaker D.J.,
Meyerson M.;
"Missense mutations of the BRAF gene in human lung adenocarcinoma.";
Cancer Res. 62:7001-7003(2002).
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[17]
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VARIANTS CANCER GLU-464; VAL-464; ALA-466; GLU-466; VAL-466; ALA-469; GLU-469; LYS-586; LEU-595; ARG-596; ARG-597; VAL-597; GLU-600 AND ASP-600, AND CHARACTERIZATION OF VARIANTS CANCER VAL-464; ALA-469; VAL-597 AND GLU-600.
DOI=10.1038/nature00766; PubMed=12068308 [NCBI, ExPASy, EBI, Israel, Japan]
Davies H.,
Bignell G.R.,
Cox C.,
Stephens P.,
Edkins S.,
Clegg S.,
Teague J.,
Woffendin H.,
Garnett M.J.,
Bottomley W.,
Davis N.,
Dicks E.,
Ewing R.,
Floyd Y.,
Gray K.,
Hall S.,
Hawes R.,
Hughes J.,
Kosmidou V., ![]()
Menzies A.,
Mould C.,
Parker A.,
Stevens C.,
Watt S.,
Hooper S.,
Wilson R.,
Jayatilake H.,
Gusterson B.A.,
Cooper C.,
Shipley J.,
Hargrave D.,
Pritchard-Jones K.,
Maitland N.,
Chenevix-Trench G.,
Riggins G.J.,
Bigner D.D.,
Palmieri G.,
Cossu A.,
Flanagan A.,
Nicholson A.,
Ho J.W.C.,
Leung S.Y.,
Yuen S.T.,
Weber B.L.,
Seigler H.F.,
Darrow T.L.,
Paterson H.,
Marais R.,
Marshall C.J.,
Wooster R.,
Stratton M.R.,
Futreal P.A.;
"Mutations of the BRAF gene in human cancer.";
Nature 417:949-954(2002).
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[18]
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VARIANTS COLORECTAL CANCER ILE-462; SER-463; GLU-464; GLU-600 AND GLU-601.
DOI=10.1038/418934a; PubMed=12198537 [NCBI, ExPASy, EBI, Israel, Japan]
Rajagopalan H.,
Bardelli A.,
Lengauer C.,
Kinzler K.W.,
Vogelstein B.,
Velculescu V.E.;
"Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.";
Nature 418:934-934(2002).
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[19]
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VARIANTS NHL ALA-469; ARG-469 AND GLY-594.
DOI=10.1038/sj.bjc.6601371; PubMed=14612909 [NCBI, ExPASy, EBI, Israel, Japan]
Lee J.W.,
Yoo N.J.,
Soung Ark W.S.,
Kim S.Y.,
Lee J.H.,
Park J.Y.,
Cho Y.G.,
Kim C.J.,
Ko Y.H.,
Kim S.H.,
Nam S.W.,
Lee J.Y.,
Lee S.H.;
"BRAF mutations in non-Hodgkin's lymphoma.";
Br. J. Cancer 89:1958-1960(2003).
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[20]
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CHARACTERIZATION OF VARIANT MELANOMA GLU-600.
PubMed=14500344 [NCBI, ExPASy, EBI, Israel, Japan]
Hingorani S.R.,
Jacobetz M.A.,
Robertson G.P.,
Herlyn M.,
Tuveson D.A.;
"Suppression of BRAF(V599E) in human melanoma abrogates transformation.";
Cancer Res. 63:5198-5202(2003).
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[21]
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VARIANTS CFC SYNDROME PRO-246; ARG-257; GLU-469; PHE-485; GLU-499; LYS-501; GLY-501 AND ASP-581.
DOI=10.1038/ng1749; PubMed=16474404 [NCBI, ExPASy, EBI, Israel, Japan]
Niihori T.,
Aoki Y.,
Narumi Y.,
Neri G.,
Cave H.,
Verloes A.,
Okamoto N.,
Hennekam R.C.M.,
Gillessen-Kaesbach G.,
Wieczorek D.,
Kavamura M.I.,
Kurosawa K.,
Ohashi H.,
Wilson L.,
Heron D.,
Bonneau D.,
Corona G.,
Kaname T.,
Naritomi K., ![]()
Baumann C.,
Matsumoto N.,
Kato K.,
Kure S.,
Matsubara Y.;
"Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.";
Nat. Genet. 38:294-296(2006).
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[22]
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VARIANT [LARGE SCALE ANALYSIS] GLU-600.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T.,
Jones S.,
Wood L.D.,
Parsons D.W.,
Lin J.,
Barber T.D.,
Mandelker D.,
Leary R.J.,
Ptak J.,
Silliman N.,
Szabo S.,
Buckhaults P.,
Farrell C.,
Meeh P.,
Markowitz S.D.,
Willis J.,
Dawson D.,
Willson J.K.V.,
Gazdar A.F., ![]()
Hartigan J.,
Wu L.,
Liu C.,
Parmigiani G.,
Park B.H.,
Bachman K.E.,
Papadopoulos N.,
Vogelstein B.,
Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
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[23]
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VARIANTS CFC SYNDROME ARG-257; ALA-467; SER-468; GLU-469; PHE-485; GLU-499; LYS-501; GLY-501; ASP-581; LEU-595 AND VAL-596.
DOI=10.1126/science.1124642; PubMed=16439621 [NCBI, ExPASy, EBI, Israel, Japan]
Rodriguez-Viciana P.,
Tetsu O.,
Tidyman W.E.,
Estep A.L.,
Conger B.A.,
Cruz M.S.,
McCormick F.,
Rauen K.A.;
"Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.";
Science 311:1287-1290(2006).
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[24]
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VARIANTS [LARGE SCALE ANALYSIS] SER-301; ALA-469; VAL-469; SER-581; ARG-596; ARG-597; VAL-597; GLU-600; GLU-600 AND GLU-600.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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