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- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA (By similarity).
- SUBUNIT: Homomultimer; disulfide-linked. The virus capsid is composed of 72 icosahedral units, each one composed of five disulfide-linked copies of VP1. Interacts with minor capsid proteins VP2 and VP3 (By similarity).
- SUBCELLULAR LOCATION: Virion. Host nucleus (By similarity).
- ALTERNATIVE PRODUCTS:
5 named isoforms [FASTA] produced by alternative splicing and alternative initiation.
| Name | VP1 |
| Isoform ID | P14996-1 |
| Note: Produced by alternative splicing of the late transcripts. |
| This is the isoform sequence displayed in this entry. |
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| Name | VP2 |
| Isoform ID | P14997-1 |
| Note: Produced by alternative splicing of the late transcripts. |
| This isoform is stored in UniProtKB/Swiss-Prot entry P14997. |
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| Name | VP3 |
| Isoform ID | P14997-2 |
| Note: Produced by alternative initiation at Met-120 of isoform VP2. |
| This isoform is stored in UniProtKB/Swiss-Prot entry P14997. |
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| Name | VP4 |
| Isoform ID | P14997-3 |
| Note: Produced by alternative initiation at Met-229 of isoform VP2. |
| This isoform is stored in UniProtKB/Swiss-Prot entry P14997. |
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| Name | Agno |
| Isoform ID | P14998-1 |
| Note: Produced by alternative initiation of the late mRNA leader region. |
| This isoform is stored in UniProtKB/Swiss-Prot entry P14998. |
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- DOMAIN: The N-terminal region contains a nuclear signal but the presence of VP2 and VP3 proteins is required for efficient nuclear transport (By similarity).
- DOMAIN: The intrinsically disordered C-terminal region interacts with neighboring pentamers. The unstructured nature of this region allows to make different interactions depending on the stuctural context: pentamers present at the 12 icosahedral fivefold axes bind five pentamers, when pentamers present at the 60 icosahedral six-fold axes interacts with six pentamers (By similarity).
- SIMILARITY: Belongs to the polyomaviruses coat protein VP1 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 362 AA [This is the length of the unprocessed precursor] |
Molecular weight: 40113 Da [This is the MW of the unprocessed precursor] |
CRC64: 5BDCEC52F247F238 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAPTKRKGEC PGAAPKKPKE PVQVPKLLIK GGVEVLEVKT GVDAITEVEC FLNPEMGDPD
70 80 90 100 110 120
DNLRGYSQHL SAENAFESDS PDRKMLPCYS TARIPLPNLN EDLTCGNLLM WEAVTVKTEV
130 140 150 160 170 180
IGITSMLNLH AGSQKVHENG GGKPVQGSNF HFFAVGGDPL EMQGVLMNYR TKYPQGTITP
190 200 210 220 230 240
KNPTAQSQVM NTDHKAYLDK NNAYPVECWI PDPSRNENTR YFGTYTGGEN VPPVLHVTNT
250 260 270 280 290 300
ATTVLLDEQG VGPLCKADSL YVSAADICGL FTNSSGTQQW RGLARYFKIR LRKRSVKNPY
310 320 330 340 350 360
PISFLLSDLI NRRTQKVDGQ PMYGMESQVE EVRVFDGTEQ LPGDPDMIRY IDRQGQLQTK
MV
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P14996 in FASTA format |
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