ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P14941

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name ADH_THEBR
Primary accession number P14941
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on April 1, 1990 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 67)
Name and origin of the protein
Protein name NADP-dependent alcohol dehydrogenase
Synonym EC 1.1.1.2
Gene name
Name: adh
From
Thermoanaerobacter brockii (Thermoanaerobium brockii) [TaxID: 29323] 
Taxonomy Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Thermoanaerobacter.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE.
STRAIN=ATCC 53556 / HTD4 / DSM 1457;
DOI=10.1021/bi00442a004; PubMed=2790012 [NCBI, ExPASy, EBI, Israel, Japan]
Peretz M., Burstein Y.;
"Amino acid sequence of alcohol dehydrogenase from the thermophilic bacterium Thermoanaerobium brockii.";
Biochemistry 28:6549-6555(1989).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 53556 / HTD4 / DSM 1457;
Burstein Y.;
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
 X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
DOI=10.1006/jmbi.1998.1750; PubMed=9836873 [NCBI, ExPASy, EBI, Israel, Japan]
Korkhin Y., Kalb A.J., Peretz M., Bogin O., Burstein Y., Frolow F.;
"NADP-dependent bacterial alcohol dehydrogenases: crystal structure, cofactor-binding and cofactor specificity of the ADHs of Clostridium beijerinckii and Thermoanaerobacter brockii.";
J. Mol. Biol. 278:967-981(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64841; CAA46053.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A32973; A32973.
3D structure databases
PDB
1BXZ; X-ray; 2.99 A; A/B/C/D=1-352.[ExPASy / RCSB / EBI]
1YKF; X-ray; 2.50 A; A/B/C/D=1-352.[ExPASy / RCSB / EBI]
2NVB; X-ray; 2.80 A; A/B/C/D=1-352.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1BXZ; -.
1YKF; -.
2NVB; -.
ModBase P14941.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P14941.
Other
LinkHub P14941; -.
ProtoNet P14941.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Direct protein sequencing; Metal-binding; NADP; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   352  352     NADP-dependent alcohol dehydrogenase. PRO_0000160749
METAL   37    37        Zinc; catalytic. 
METAL   59    59        Zinc; catalytic. 
METAL   150   150        Zinc; catalytic. 
STRAND   2     8  7      
STRAND   11    16  6      
STRAND   27    35  9      
HELIX   38    45  8      
STRAND   53    56  4      
STRAND   60    68  9      
STRAND   80    83  4      
STRAND   90    92  3      
HELIX   93    96  4      
HELIX   100   102  3      
TURN   106   109  4      
TURN   112   114  3      
STRAND   121   128  8      
HELIX   129   132  4      
HELIX   142   145  4      
TURN   146   150  5      
HELIX   151   161  11      
STRAND   170   173  4      
HELIX   177   187  11      
TURN   188   190  3      
STRAND   192   197  6      
HELIX   201   210  10      
STRAND   213   216  4      
HELIX   218   220  3      
HELIX   223   230  8      
TURN   231   233  3      
STRAND   236   241  6      
HELIX   248   255  8      
STRAND   256   264  9      
STRAND   270   272  3      
TURN   278   285  8      
STRAND   289   293  5      
HELIX   299   310  12      
HELIX   316   319  4      
STRAND   320   326  7      
HELIX   328   338  11      
STRAND   345   350  6      
Sequence information
Length: 352 AA [This is the length of the unprocessed precursor] Molecular weight: 37647 Da [This is the MW of the unprocessed precursor] CRC64: E124A5351AD55185 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKGFAMLSIG KVGWIEKEKP APGPFDAIVR PLAVAPCTSD IHTVFEGAIG ERHNMILGHE 

        70         80         90        100        110        120 
AVGEVVEVGS EVKDFKPGDR VVVPAITPDW RTSEVQRGYH QHSGGMLAGW KFSNVKDGVF 

       130        140        150        160        170        180 
GEFFHVNDAD MNLAHLPKEI PLEAAVMIPD MMTTGFHGAE LADIELGATV AVLGIGPVGL 

       190        200        210        220        230        240 
MAVAGAKLRG AGRIIAVGSR PVCVDAAKYY GATDIVNYKD GPIESQIMNL TEGKGVDAAI 

       250        260        270        280        290        300 
IAGGNADIMA TAVKIVKPGG TIANVNYFGE GEVLPVPRLE WGCGMAHKTI KGGLCPGGRL 

       310        320        330        340        350 
RMERLIDLVF YKRVDPSKLV THVFRGFDNI EKAFMLMKDK PKDLIKPVVI LA
P14941 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!