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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
STRAIN=BALB/c;
DOI=10.1016/0014-5793(89)81679-5; PubMed=2532153 [NCBI, ExPASy, EBI, Israel, Japan]
Tominaga S.;
"A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor.";
FEBS Lett. 258:301-304(1989).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
STRAIN=C3H/He;
TISSUE=Spleen;
PubMed=1832015 [NCBI, ExPASy, EBI, Israel, Japan]
Tominaga S.,
Jenkins N.A.,
Gilbert D.J.,
Copeland N.G.,
Tetsuka T.;
"Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.";
Biochim. Biophys. Acta 1090:1-8(1991).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
DOI=10.1073/pnas.86.15.5708; PubMed=2527364 [NCBI, ExPASy, EBI, Israel, Japan]
Klemenz R.,
Hoffmann S.,
Werenskiold A.K.;
"Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen.";
Proc. Natl. Acad. Sci. U.S.A. 86:5708-5712(1989).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
DOI=10.1016/0014-5793(93)81333-U; PubMed=7916701 [NCBI, ExPASy, EBI, Israel, Japan]
Yanagisawa K.,
Takagi T.,
Tsukamoto T.,
Tetsuka T.,
Tominaga S.;
"Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.";
FEBS Lett. 318:83-87(1993).
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[5]
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TISSUE SPECIFICITY.
PubMed=8131748 [NCBI, ExPASy, EBI, Israel, Japan]
Bergers G.,
Reikersdorfer A.,
Braselmann S.,
Graninger P.,
Busslinger M.;
"Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.";
EMBO J. 13:1176-1188(1994).
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- FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function.
- SUBUNIT: Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity).
- INTERACTION:
Q62406-2:Irak1; NbExp=1; IntAct=EBI-525078, EBI-488317;
P22366:Myd88; NbExp=1; IntAct=EBI-525078, EBI-525108;
Q9QZ06:Tollip; NbExp=1; IntAct=EBI-525078, EBI-74272;
- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
- SUBCELLULAR LOCATION: Isoform B: Secreted.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
- TISSUE SPECIFICITY: Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines.
- DEVELOPMENTAL STAGE: Expressed first in the fetal liver and then in lung and hematopoietic tissues.
- SIMILARITY: Belongs to the interleukin-1 receptor family.
- SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
- SIMILARITY: Contains 1 TIR domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 567 AA [This is the length of the unprocessed precursor] |
Molecular weight: 64801 Da [This is the MW of the unprocessed precursor] |
CRC64: 9228CE227D95B0BC [This is a checksum on the sequence] |
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10 20 30 40 50 60
MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN
70 80 90 100 110 120
ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP
130 140 150 160 170 180
DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD
190 200 210 220 230 240
DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC
250 260 270 280 290 300
SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK
310 320 330 340 350 360
DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV LVIVLKVFWI
370 380 390 400 410 420
EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH SVEYFVHHTL PDVLENKCGY
430 440 450 460 470 480
KLCIYGRDLL PGQDAATVVE SSIQNSRRQV FVLAPHMMHS KEFAYEQEIA LHSALIQNNS
490 500 510 520 530 540
KVILIEMEPL GEASRLQVGD LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM
550 560
PVPERASKTA SVAAPLSGKA CLDLKHF
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P14719 in FASTA format |
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